Gene description for FER
Gene name fer (fps/fes related) tyrosine kinase
Gene symbol FER
Other names/aliases PPP1R74
TYK3
p94-Fer
Species Homo sapiens
 Database cross references - FER
ExoCarta ExoCarta_2241
Vesiclepedia VP_2241
Entrez Gene 2241
HGNC 3655
MIM 176942
UniProt P16591  
 FER identified in sEVs derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
 Gene ontology annotations for FER
Molecular Function
    protein tyrosine kinase activity GO:0004713 IBA
    non-membrane spanning protein tyrosine kinase activity GO:0004715 IDA
    epidermal growth factor receptor binding GO:0005154 IDA
    protein binding GO:0005515 IPI
    ATP binding GO:0005524 IEA
    protein phosphatase 1 binding GO:0008157 IEA
    lipid binding GO:0008289 IDA
    histone H3Y41 kinase activity GO:0035401 IEA
    histone H2AXY142 kinase activity GO:0140801 IEA
Biological Process
    microtubule cytoskeleton organization GO:0000226 IMP
    regulation of protein phosphorylation GO:0001932 ISS
    chromatin remodeling GO:0006338 IEA
    protein phosphorylation GO:0006468 TAS
    chemotaxis GO:0006935 IBA
    cell adhesion GO:0007155 IBA
    tyrosine phosphorylation of STAT protein GO:0007260 IDA
    germ cell development GO:0007281 IEA
    positive regulation of cell population proliferation GO:0008284 IMP
    positive regulation of cell population proliferation GO:0008284 TAS
    insulin receptor signaling pathway GO:0008286 ISS
    regulation of lamellipodium assembly GO:0010591 IDA
    regulation of fibroblast migration GO:0010762 IEA
    peptidyl-tyrosine phosphorylation GO:0018108 IDA
    cytokine-mediated signaling pathway GO:0019221 IMP
    actin cytoskeleton organization GO:0030036 ISS
    positive regulation of cell migration GO:0030335 IMP
    positive regulation of actin filament polymerization GO:0030838 IMP
    response to lipopolysaccharide GO:0032496 ISS
    negative regulation of mast cell activation involved in immune response GO:0033007 ISS
    adherens junction assembly GO:0034333 IEA
    substrate adhesion-dependent cell spreading GO:0034446 ISS
    cellular response to reactive oxygen species GO:0034614 ISS
    extracellular matrix-cell signaling GO:0035426 ISS
    intracellular signal transduction GO:0035556 TAS
    cellular response to macrophage colony-stimulating factor stimulus GO:0036006 IMP
    response to platelet-derived growth factor GO:0036119 ISS
    Fc-epsilon receptor signaling pathway GO:0038095 IBA
    Fc-epsilon receptor signaling pathway GO:0038095 ISS
    Kit signaling pathway GO:0038109 ISS
    regulation of epidermal growth factor receptor signaling pathway GO:0042058 IMP
    cell-cell adhesion mediated by cadherin GO:0044331 ISS
    protein autophosphorylation GO:0046777 IDA
    platelet-derived growth factor receptor signaling pathway GO:0048008 ISS
    platelet-derived growth factor receptor signaling pathway GO:0048008 TAS
    diapedesis GO:0050904 ISS
    positive regulation of NF-kappaB transcription factor activity GO:0051092 IMP
    positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction GO:0051897 IEA
    Sertoli cell development GO:0060009 IEA
    interleukin-6-mediated signaling pathway GO:0070102 IMP
    seminiferous tubule development GO:0072520 IEA
    adherens junction disassembly GO:0120179 IEA
Subcellular Localization
    chromatin GO:0000785 IDA
    nucleus GO:0005634 IDA
    cytoplasm GO:0005737 IDA
    cytosol GO:0005829 IDA
    cytosol GO:0005829 TAS
    plasma membrane GO:0005886 IBA
    adherens junction GO:0005912 IEA
    cell cortex GO:0005938 IEA
    cytoplasmic side of plasma membrane GO:0009898 IDA
    actin cytoskeleton GO:0015629 IDA
    microtubule cytoskeleton GO:0015630 IDA
    lamellipodium GO:0030027 IDA
    cell junction GO:0030054 IDA
    protein-containing complex GO:0032991 IEA
 Experiment description of studies that identified FER in sEVs
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for FER
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 TMF1 7110
Two-hybrid Homo sapiens
Biochemical Activity Homo sapiens
2 LIMA1 51474
Affinity Capture-MS Homo sapiens
3 DNM1 1759
Co-fractionation Homo sapiens
4 ERBB2 2064
Protein-peptide Homo sapiens
Reconstituted Complex Homo sapiens
5 DVL2 1856
Affinity Capture-MS Homo sapiens
6 FBXL6  
Proximity Label-MS Homo sapiens
7 CTNNB1 1499
Biochemical Activity Homo sapiens
8 CDC37 11140
Affinity Capture-Luminescence Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
9 SQSTM1 8878
Proximity Label-MS Homo sapiens
10 CTTN 2017
Affinity Capture-Western Homo sapiens
Co-fractionation Homo sapiens
Biochemical Activity Homo sapiens
Co-fractionation Homo sapiens
11 EGFR 1956
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
12 PTK2 5747
Co-fractionation Homo sapiens
13 HSP90AA1 3320
Affinity Capture-Luminescence Homo sapiens
14 ERBB3 2065
Reconstituted Complex Homo sapiens
Protein-peptide Homo sapiens
15 NXF1 10482
Affinity Capture-RNA Homo sapiens
16 FKBP5 2289
Affinity Capture-MS Homo sapiens
17 CDH1 999
Reconstituted Complex Homo sapiens
18 DNAI2  
Affinity Capture-MS Homo sapiens
19 DNM3 26052
Co-fractionation Homo sapiens
20 ARC  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
21 DNAJC1 64215
Co-fractionation Homo sapiens
22 DNM2 1785
Co-fractionation Homo sapiens
23 FER 2241
Biochemical Activity Homo sapiens
Reconstituted Complex Homo sapiens
Biochemical Activity Homo sapiens
Reconstituted Complex Homo sapiens
View the network image/svg+xml
 Pathways in which FER is involved
PathwayEvidenceSource
Signal Transduction TAS Reactome
Signaling by Receptor Tyrosine Kinases TAS Reactome
Signaling by SCF-KIT TAS Reactome





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