Gene description for FES
Gene name FES proto-oncogene, tyrosine kinase
Gene symbol FES
Other names/aliases FPS
Species Homo sapiens
 Database cross references - FES
ExoCarta ExoCarta_2242
Vesiclepedia VP_2242
Entrez Gene 2242
HGNC 3657
MIM 190030
UniProt P07332  
 FES identified in sEVs derived from the following tissue/cell type
Thymus 23844026    
 Gene ontology annotations for FES
Molecular Function
    protein tyrosine kinase activity GO:0004713 IBA
    protein tyrosine kinase activity GO:0004713 IDA
    protein tyrosine kinase activity GO:0004713 TAS
    non-membrane spanning protein tyrosine kinase activity GO:0004715 IDA
    protein binding GO:0005515 IPI
    ATP binding GO:0005524 IEA
    microtubule binding GO:0008017 IEA
    immunoglobulin receptor binding GO:0034987 IDA
    phosphatidylinositol binding GO:0035091 IDA
    histone H3Y41 kinase activity GO:0035401 IEA
    histone H2AXY142 kinase activity GO:0140801 IEA
Biological Process
    microtubule bundle formation GO:0001578 IEA
    chromatin remodeling GO:0006338 IEA
    chemotaxis GO:0006935 IBA
    centrosome cycle GO:0007098 IEA
    cell adhesion GO:0007155 IBA
    regulation of cell shape GO:0008360 IMP
    positive regulation of neuron projection development GO:0010976 IMP
    peptidyl-tyrosine phosphorylation GO:0018108 IDA
    regulation of cell adhesion GO:0030155 IMP
    positive regulation of microtubule polymerization GO:0031116 IMP
    regulation of cell population proliferation GO:0042127 IMP
    regulation of mast cell degranulation GO:0043304 IMP
    regulation of cell differentiation GO:0045595 IMP
    positive regulation of myeloid cell differentiation GO:0045639 IMP
    positive regulation of monocyte differentiation GO:0045657 IMP
    protein autophosphorylation GO:0046777 IDA
    myoblast proliferation GO:0051450 IEA
    cardiac muscle cell proliferation GO:0060038 IEA
    regulation of vesicle-mediated transport GO:0060627 TAS
    cellular response to vitamin D GO:0071305 IMP
    regulation of cell motility GO:2000145 IMP
Subcellular Localization
    cytoplasm GO:0005737 IDA
    Golgi apparatus GO:0005794 IEA
    cytosol GO:0005829 TAS
    plasma membrane GO:0005886 IBA
    focal adhesion GO:0005925 IDA
    cytoplasmic side of plasma membrane GO:0009898 IDA
    microtubule cytoskeleton GO:0015630 IDA
    cytoplasmic vesicle GO:0031410 IDA
 Experiment description of studies that identified FES in sEVs
1
Experiment ID 217
MISEV standards
EM
Biophysical techniques
TSG101|CD81|CD9|CD63
Enriched markers
Negative markers
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23844026    
Organism Homo sapiens
Experiment description Characterization of human thymic exosomes.
Authors "Skogberg G, Gudmundsdottir J, van der Post S, Sandstrom K, Bruhn S, Benson M, Mincheva-Nilsson L, Baranov V, Telemo E, Ekwall O."
Journal name PLoS One
Publication year 2013
Sample Thymus
Sample name Normal-Thymus
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for FES
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 ERBB2 2064
Reconstituted Complex Homo sapiens
2 NEDD4 4734
Reconstituted Complex Homo sapiens
3 POT1  
Two-hybrid Homo sapiens
4 PSMD13 5719
Affinity Capture-MS Homo sapiens
5 ZNF746  
Two-hybrid Homo sapiens
6 PPID 5481
Reconstituted Complex Homo sapiens
7 KIT 3815
Reconstituted Complex Homo sapiens
8 SMURF1 57154
Biochemical Activity Homo sapiens
9 ERBB4 2066
Reconstituted Complex Homo sapiens
10 EGFR 1956
Protein-peptide Homo sapiens
Reconstituted Complex Homo sapiens
11 FKBP4 2288
Reconstituted Complex Homo sapiens
12 HSP90AA1 3320
Affinity Capture-Luminescence Homo sapiens
Reconstituted Complex Homo sapiens
13 ERBB3 2065
Reconstituted Complex Homo sapiens
14 APP 351
Reconstituted Complex Homo sapiens
15 GAB1  
Reconstituted Complex Homo sapiens
16 HSPA4 3308
Reconstituted Complex Homo sapiens
17 FKBP5 2289
Reconstituted Complex Homo sapiens
18 TERF1 7013
Two-hybrid Homo sapiens
19 TRIM28 10155
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
20 HSH2D 84941
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
21 ZNF775  
Two-hybrid Homo sapiens
22 FES 2242
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
23 MET 4233
Reconstituted Complex Homo sapiens
24 PDE4DIP 9659
Two-hybrid Homo sapiens
25 PTGES3 10728
Reconstituted Complex Homo sapiens
26 STAT3 6774
Affinity Capture-Western Homo sapiens
27 PIK3R1 5295
Affinity Capture-Western Homo sapiens
28 AR 367
Reconstituted Complex Homo sapiens
29 BCR 613
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
30 DSP 1832
Affinity Capture-MS Homo sapiens
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