Gene description for Abce1
Gene name ATP-binding cassette, sub-family E (OABP), member 1
Gene symbol Abce1
Other names/aliases C79080
Oabp
RLI
RNS41
Rnaseli
Species Mus musculus
 Database cross references - Abce1
ExoCarta ExoCarta_24015
Vesiclepedia VP_24015
Entrez Gene 24015
UniProt P61222  
 Abce1 identified in sEVs derived from the following tissue/cell type
Colon cancer cells 37309723    
T-cell lymphoma cells 37309723    
 Gene ontology annotations for Abce1
Molecular Function
    GTPase activity GO:0003924 ISO
    GTPase activity GO:0003924 ISS
    iron ion binding GO:0005506 IBA
    ATP binding GO:0005524 IBA
    ATP binding GO:0005524 IEA
    ATP hydrolysis activity GO:0016887 ISO
    ATP hydrolysis activity GO:0016887 ISS
    ribonucleoside triphosphate phosphatase activity GO:0017111 ISO
    ribosomal small subunit binding GO:0043024 IBA
    CTPase activity GO:0043273 ISO
    CTPase activity GO:0043273 ISS
    metal ion binding GO:0046872 IEA
    4 iron, 4 sulfur cluster binding GO:0051539 IEA
    endoribonuclease inhibitor activity GO:0060698 IEA
Biological Process
    translational initiation GO:0006413 IBA
    translational termination GO:0006415 IBA
    translational termination GO:0006415 IEA
    translational termination GO:0006415 ISO
    regulation of translation GO:0006417 IEA
    ribosome disassembly GO:0032790 ISO
    ribosome disassembly GO:0032790 ISS
    rescue of stalled ribosome GO:0072344 ISO
    rescue of stalled ribosome GO:0072344 ISS
Subcellular Localization
    cytoplasm GO:0005737 ISO
    cytoplasm GO:0005737 ISS
    mitochondrion GO:0005739 ISO
    mitochondrion GO:0005739 ISS
    cytosol GO:0005829 IBA
    cytosol GO:0005829 ISO
    cytosolic ribosome GO:0022626 IEA
    cytosolic ribosome GO:0022626 ISO
 Experiment description of studies that identified Abce1 in sEVs
1
Experiment ID 907
MISEV standards
✔
EM
Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
Enriched markers
✔
HSPA5
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample Colon cancer cells
Sample name C26
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 908
MISEV standards
✔
EM
Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
Enriched markers
✔
HSPA5
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample T-cell lymphoma cells
Sample name EL4
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for Abce1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Polr1a  
Co-fractionation Mus musculus
2 D2Wsu81e  
Co-fractionation Mus musculus
3 Ctps 51797
Co-fractionation Mus musculus
4 Nsun2 28114
Co-fractionation Mus musculus
5 Lars 107045
Co-fractionation Mus musculus
6 Trmt1  
Co-fractionation Mus musculus
7 Rpl13a 22121
Co-fractionation Mus musculus
8 Noc3l  
Co-fractionation Mus musculus
9 Impdh1  
Co-fractionation Mus musculus
10 Rps4x 20102
Co-fractionation Mus musculus
11 Pdcd11  
Co-fractionation Mus musculus
12 Rps2 16898
Co-fractionation Mus musculus
13 Polr3b  
Co-fractionation Mus musculus
14 Rpl7a 27176
Co-fractionation Mus musculus
15 Dhodh  
Co-fractionation Mus musculus
16 Atxn1  
Affinity Capture-MS Mus musculus
17 Mthfd2l  
Co-fractionation Mus musculus
18 Rpl6 19988
Co-fractionation Mus musculus
19 Ddx27  
Co-fractionation Mus musculus
20 Wdr6  
Co-fractionation Mus musculus
21 Tmem165  
Co-fractionation Mus musculus
22 Gar1  
Co-fractionation Mus musculus
23 Imp3  
Co-fractionation Mus musculus
24 Mthfd2  
Co-fractionation Mus musculus
25 Rpl35a 57808
Co-fractionation Mus musculus
26 Rpl22 19934
Co-fractionation Mus musculus
27 Gnl2  
Co-fractionation Mus musculus
28 Nop14  
Co-fractionation Mus musculus
29 Pinx1  
Co-fractionation Mus musculus
30 Gnl3  
Co-fractionation Mus musculus
31 Ranbp6  
Co-fractionation Mus musculus
32 Wdr43  
Co-fractionation Mus musculus
33 Abcf2 27407
Co-fractionation Mus musculus
34 Lsg1  
Co-fractionation Mus musculus
35 Gtpbp4  
Co-fractionation Mus musculus
36 Pwp2  
Co-fractionation Mus musculus
37 Sdad1  
Co-fractionation Mus musculus
38 Rps3a1 20091
Co-fractionation Mus musculus
39 Rps14 20044
Co-fractionation Mus musculus
40 Eed  
Affinity Capture-MS Mus musculus
41 Hgh1 59053
Co-fractionation Mus musculus
42 Atg16l1  
Affinity Capture-MS Mus musculus
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