Gene description for Ppp2r5c
Gene name protein phosphatase 2, regulatory subunit B', gamma
Gene symbol Ppp2r5c
Other names/aliases 2610043M05Rik
2700063L20Rik
AI060890
AW545884
C85228
D12Bwg0916e
mKIAA0044
Species Mus musculus
 Database cross references - Ppp2r5c
ExoCarta ExoCarta_26931
Vesiclepedia VP_26931
Entrez Gene 26931
UniProt Q60996  
 Ppp2r5c identified in sEVs derived from the following tissue/cell type
Mast cells 17486113    
 Gene ontology annotations for Ppp2r5c
Molecular Function
    protein binding GO:0005515 IPI
    protein phosphatase regulator activity GO:0019888 IEA
    protein phosphatase regulator activity GO:0019888 ISO
    protein phosphatase activator activity GO:0072542 IBA
Biological Process
    DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest GO:0006977 ISO
    signal transduction GO:0007165 IEA
    negative regulation of cell population proliferation GO:0008285 ISO
    intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator GO:0042771 ISO
    proteasome-mediated ubiquitin-dependent protein catabolic process GO:0043161 ISO
    meiotic sister chromatid cohesion GO:0051177 IBA
Subcellular Localization
    protein phosphatase type 2A complex GO:0000159 IBA
    protein phosphatase type 2A complex GO:0000159 ISO
    protein phosphatase type 2A complex GO:0000159 ISS
    chromosome, centromeric region GO:0000775 ISO
    chromosome, centromeric region GO:0000775 ISS
    nucleus GO:0005634 IBA
    nucleus GO:0005634 ISO
    nucleus GO:0005634 TAS
    nucleoplasm GO:0005654 ISO
    Golgi apparatus GO:0005794 ISO
    cytosol GO:0005829 IBA
    cytosol GO:0005829 ISO
 Experiment description of studies that identified Ppp2r5c in sEVs
1
Experiment ID 15
MISEV standards
EM
Biophysical techniques
CD63
Enriched markers
Negative markers
Particle analysis
Identified molecule mrna
Identification method Microarray
PubMed ID 17486113    
Organism Mus musculus
Homo sapiens
Experiment description Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells.
Authors "Valadi H, Ekstrom K, Bossios A, Sjostrand M, Lee JJ, Lotvall JO"
Journal name NCB
Publication year 2007
Sample Mast cells
Sample name MC9
Bone marrow-derived mast cells
HMC-1
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.11-1.21 g/mL
Molecules identified in the study Protein
mRNA
miRNA
Methods used in the study Mass spectrometry [MALDI TOF]
Western blotting
Microarray
miRCURY LNA Array
 Protein-protein interactions for Ppp2r5c
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 ELL2 22936
Affinity Capture-MS Homo sapiens
2 Lnx1  
Affinity Capture-MS Mus musculus
3 Ppp2r4 110854
Co-fractionation Mus musculus
4 ADNP2  
Affinity Capture-MS Homo sapiens
5 Eed  
Affinity Capture-MS Mus musculus
6 PPP2R1B 5519
Affinity Capture-MS Homo sapiens
7 Snrnp200 320632
Co-fractionation Mus musculus
8 PPP2R1A 5518
Affinity Capture-MS Homo sapiens
9 Swap70  
Co-fractionation Mus musculus
10 U2AF2 11338
Affinity Capture-MS Homo sapiens
11 Ugp2 216558
Co-fractionation Mus musculus
View the network image/svg+xml
 Pathways in which Ppp2r5c is involved
PathwayEvidenceSource
Adaptive Immune System IEA Reactome
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal IEA Reactome
Amplification of signal from the kinetochores IEA Reactome
Beta-catenin phosphorylation cascade IEA Reactome
Cell Cycle IEA Reactome
Cell Cycle Checkpoints IEA Reactome
Cell Cycle, Mitotic IEA Reactome
Costimulation by the CD28 family IEA Reactome
CTLA4 inhibitory signaling IEA Reactome
Degradation of beta-catenin by the destruction complex IEA Reactome
Disassembly of the destruction complex and recruitment of AXIN to the membrane IEA Reactome
EML4 and NUDC in mitotic spindle formation IEA Reactome
Gene expression (Transcription) IEA Reactome
Generic Transcription Pathway IEA Reactome
Hemostasis IEA Reactome
Immune System IEA Reactome
Intracellular signaling by second messengers IEA Reactome
M Phase IEA Reactome
MAPK family signaling cascades IEA Reactome
MAPK1/MAPK3 signaling IEA Reactome
Mitotic Anaphase IEA Reactome
Mitotic Metaphase and Anaphase IEA Reactome
Mitotic Prometaphase IEA Reactome
Mitotic Spindle Checkpoint IEA Reactome
Negative regulation of MAPK pathway IEA Reactome
Negative regulation of the PI3K/AKT network IEA Reactome
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling IEA Reactome
PIP3 activates AKT signaling IEA Reactome
Platelet homeostasis IEA Reactome
Platelet sensitization by LDL IEA Reactome
RAF activation IEA Reactome
RAF/MAP kinase cascade IEA Reactome
Regulation of TP53 Activity IEA Reactome
Regulation of TP53 Degradation IEA Reactome
Regulation of TP53 Expression and Degradation IEA Reactome
Resolution of Sister Chromatid Cohesion IEA Reactome
RHO GTPase Effectors IEA Reactome
RHO GTPases Activate Formins IEA Reactome
RNA Polymerase II Transcription IEA Reactome
Separation of Sister Chromatids IEA Reactome
Signal Transduction IEA Reactome
Signaling by Rho GTPases IEA Reactome
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 IEA Reactome
Signaling by WNT IEA Reactome
TCF dependent signaling in response to WNT IEA Reactome
Transcriptional Regulation by TP53 IEA Reactome





Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here