Gene description for PKD2L2
Gene name polycystic kidney disease 2-like 2
Gene symbol PKD2L2
Other names/aliases TRPP5
Species Homo sapiens
 Database cross references - PKD2L2
ExoCarta ExoCarta_27039
Vesiclepedia VP_27039
Entrez Gene 27039
HGNC 9012
MIM 604669
UniProt Q9NZM6  
 PKD2L2 identified in sEVs derived from the following tissue/cell type
Prostate cancer cells 25844599    
 Gene ontology annotations for PKD2L2
Molecular Function
    calcium channel activity GO:0005262 IBA
    calcium ion binding GO:0005509 IEA
Biological Process
    detection of mechanical stimulus GO:0050982 IBA
    calcium ion transmembrane transport GO:0070588 IEA
Subcellular Localization
    membrane GO:0016020 IBA
    membrane GO:0016020 TAS
 Experiment description of studies that identified PKD2L2 in sEVs
1
Experiment ID 275
MISEV standards
EM
Biophysical techniques
TSG101|Alix|RAB5A|CD9|CD82|CD63|CD81
Enriched markers
AIF
Negative markers
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25844599    
Organism Homo sapiens
Experiment description Molecular profiling of prostate cancer derived exosomes may reveal a predictive signature for response to docetaxel.
Authors "Kharaziha P, Chioureas D, Rutishauser D, Baltatzis G, Lennartsson L, Fonseca P, Azimi A, Hultenby K, Zubarev R, Ullen A, Yachnin J, Nilsson S, Panaretakis T."
Journal name Oncotarget
Publication year 2015
Sample Prostate cancer cells
Sample name DU145 - Docetaxel sensitive
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.12-1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry/Flow cytometry/Western blotting
 Protein-protein interactions for PKD2L2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 PKD2 5311
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
2 GRAMD1A  
Affinity Capture-MS Homo sapiens
3 TRPM7 54822
Affinity Capture-MS Homo sapiens
4 SEMG1 6406
Affinity Capture-MS Homo sapiens
5 SERPINB3 6317
Affinity Capture-MS Homo sapiens
6 ITPR3 3710
Affinity Capture-MS Homo sapiens
7 TRPM4 54795
Affinity Capture-MS Homo sapiens
8 SERPINB4 6318
Affinity Capture-MS Homo sapiens
9 CCPG1 9236
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
10 DNAJB9 4189
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which PKD2L2 is involved
No pathways found





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