Gene description for SEMG1
Gene name semenogelin I
Gene symbol SEMG1
Other names/aliases CT103
SEMG
SGI
dJ172H20.2
Species Homo sapiens
 Database cross references - SEMG1
ExoCarta ExoCarta_6406
Vesiclepedia VP_6406
Entrez Gene 6406
HGNC 10742
MIM 182140
UniProt P04279  
 SEMG1 identified in sEVs derived from the following tissue/cell type
Urine 22418980    
Urine 22418980    
 Gene ontology annotations for SEMG1
Molecular Function
    protein binding GO:0005515 IPI
    zinc ion binding GO:0008270 IMP
Biological Process
    insemination GO:0007320 TAS
    antibacterial humoral response GO:0019731 IDA
    killing of cells of another organism GO:0031640 IDA
    sperm capacitation GO:0048240 IBA
    coagulation GO:0050817 IDA
    antimicrobial humoral immune response mediated by antimicrobial peptide GO:0061844 IDA
    negative regulation of calcium ion import GO:0090281 IDA
    positive regulation of serine-type endopeptidase activity GO:1900005 IMP
    negative regulation of flagellated sperm motility GO:1901318 IDA
    negative regulation of flagellated sperm motility GO:1901318 IMP
Subcellular Localization
    extracellular region GO:0005576 TAS
    extracellular space GO:0005615 IDA
    extracellular space GO:0005615 TAS
    nucleus GO:0005634 HDA
    protein-containing complex GO:0032991 IDA
    extracellular exosome GO:0070062 HDA
 Experiment description of studies that identified SEMG1 in sEVs
1
Experiment ID 196
MISEV standards
EM
Biophysical techniques
Alix|TSG101|HSP70|CD9
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 22418980    
Organism Homo sapiens
Experiment description A multiplex quantitative proteomics strategy for protein biomarker studies in urinary exosomes.
Authors "Raj DA, Fiume I, Capasso G, Pocsfalvi G."
Journal name Kidney Int
Publication year 2012
Sample Urine
Sample name Urine - Normal high density
Isolation/purification methods Differential centrifugation
Sucrose cushion
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
2
Experiment ID 197
MISEV standards
EM
Biophysical techniques
Alix|TSG101|HSP70|CD9
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 22418980    
Organism Homo sapiens
Experiment description A multiplex quantitative proteomics strategy for protein biomarker studies in urinary exosomes.
Authors "Raj DA, Fiume I, Capasso G, Pocsfalvi G."
Journal name Kidney Int
Publication year 2012
Sample Urine
Sample name Urine - Normal low density
Isolation/purification methods Differential centrifugation
Sucrose cushion
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for SEMG1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 PSMB9 5698
Affinity Capture-MS Homo sapiens
2 C9orf139  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
3 COLGALT2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
4 UNC50  
Affinity Capture-MS Homo sapiens
5 PTPRF 5792
Two-hybrid Homo sapiens
6 TXNDC16 57544
Affinity Capture-MS Homo sapiens
7 UBQLN4 56893
Two-hybrid Homo sapiens
8 NYAP2  
Affinity Capture-MS Homo sapiens
9 FANCD2  
Affinity Capture-MS Homo sapiens
10 OTOP1  
Affinity Capture-MS Homo sapiens
11 MRPL46  
Affinity Capture-MS Homo sapiens
12 MAT2B 27430
Affinity Capture-MS Homo sapiens
13 BAZ1B 9031
Affinity Capture-MS Homo sapiens
14 SNTB2 6645
Affinity Capture-MS Homo sapiens
15 MSS51  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
16 CECR2  
Affinity Capture-MS Homo sapiens
17 ZNF550  
Affinity Capture-MS Homo sapiens
18 SYT16  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
19 FOXP3  
Affinity Capture-MS Homo sapiens
20 SEMG2 6407
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
21 SLC22A13 9390
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
22 SLC39A7 7922
Affinity Capture-MS Homo sapiens
23 EPB41L5 57669
Affinity Capture-MS Homo sapiens
24 ZSWIM2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
25 FAM109B  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
26 BSPRY 54836
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
27 OR13G1  
Affinity Capture-MS Homo sapiens
28 PKD2L2 27039
Affinity Capture-MS Homo sapiens
29 ACPP 55
Affinity Capture-MS Homo sapiens
30 PTPLA  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
31 ZNF330  
Affinity Capture-MS Homo sapiens
32 LSM14B 149986
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
33 CLU 1191
Affinity Capture-Western Homo sapiens
34 TET2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
35 FTH1 2495
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
36 TPPP 11076
Affinity Capture-MS Homo sapiens
37 AZGP1 563
Affinity Capture-MS Homo sapiens
38 UBQLN2 29978
Two-hybrid Homo sapiens
39 SOX2  
Affinity Capture-MS Homo sapiens
40 RDH11 51109
Affinity Capture-MS Homo sapiens
41 FKBP14  
Affinity Capture-MS Homo sapiens
42 LYZL6  
Affinity Capture-MS Homo sapiens
43 SP6  
Affinity Capture-MS Homo sapiens
44 MAPK8IP2  
Affinity Capture-MS Homo sapiens
45 CD27  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
46 FBXW4 6468
Affinity Capture-MS Homo sapiens
47 CDK2 1017
Affinity Capture-MS Homo sapiens
48 MSMB  
Affinity Capture-MS Homo sapiens
49 TM2D3  
Affinity Capture-MS Homo sapiens
50 NUPR1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
51 TUBA1B 10376
Affinity Capture-MS Homo sapiens
52 KLK3  
Affinity Capture-MS Homo sapiens
53 IFNW1  
Affinity Capture-MS Homo sapiens
54 SAV1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
55 PCDHB16  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
56 PINK1  
Affinity Capture-MS Homo sapiens
57 LRP2 4036
Affinity Capture-MS Homo sapiens
58 NSUN7  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
59 DLX6  
Affinity Capture-MS Homo sapiens
60 DHH  
Affinity Capture-MS Homo sapiens
61 PLCZ1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
62 CNGA3  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
63 PPP2R2B 5521
Affinity Capture-MS Homo sapiens
64 EAF1  
Two-hybrid Homo sapiens
65 PRSS1 5644
Affinity Capture-MS Homo sapiens
66 POLL  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
67 PIK3R2 5296
Affinity Capture-MS Homo sapiens
68 KIR2DL4  
Affinity Capture-MS Homo sapiens
69 NXPH3  
Affinity Capture-MS Homo sapiens
70 BHLHE23  
Affinity Capture-MS Homo sapiens
71 SEH1L 81929
Affinity Capture-MS Homo sapiens
72 HAT1 8520
Affinity Capture-MS Homo sapiens
73 AQP12B  
Affinity Capture-MS Homo sapiens
74 TIMD4  
Affinity Capture-MS Homo sapiens
75 MTIF3  
Affinity Capture-MS Homo sapiens
76 COL4A2 1284
Affinity Capture-MS Homo sapiens
77 KIF2C 11004
Affinity Capture-MS Homo sapiens
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