Gene description for C11orf54
Gene name chromosome 11 open reading frame 54
Gene symbol C11orf54
Other names/aliases PTD012
PTOD012
Species Homo sapiens
 Database cross references - C11orf54
ExoCarta ExoCarta_28970
Vesiclepedia VP_28970
Entrez Gene 28970
HGNC 30204
MIM 615810
UniProt Q9H0W9  
 C11orf54 identified in sEVs derived from the following tissue/cell type
Thymus 23844026    
Urine 19056867    
Urine 21595033    
Urine 21595033    
Urine 21595033    
 Gene ontology annotations for C11orf54
Molecular Function
    protein binding GO:0005515 IPI
    zinc ion binding GO:0008270 IBA
    zinc ion binding GO:0008270 IDA
    hydrolase activity, acting on ester bonds GO:0016788 IBA
    hydrolase activity, acting on ester bonds GO:0016788 IDA
Subcellular Localization
    nucleus GO:0005634 IBA
    nucleus GO:0005634 IDA
    nucleoplasm GO:0005654 IDA
    nuclear body GO:0016604 IDA
    extracellular exosome GO:0070062 HDA
 Experiment description of studies that identified C11orf54 in sEVs
1
Experiment ID 217
MISEV standards
EM
Biophysical techniques
TSG101|CD81|CD9|CD63
Enriched markers
Negative markers
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23844026    
Organism Homo sapiens
Experiment description Characterization of human thymic exosomes.
Authors "Skogberg G, Gudmundsdottir J, van der Post S, Sandstrom K, Bruhn S, Benson M, Mincheva-Nilsson L, Baranov V, Telemo E, Ekwall O."
Journal name PLoS One
Publication year 2013
Sample Thymus
Sample name Normal-Thymus
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
2
Experiment ID 63
MISEV standards
Biophysical techniques
AQP2
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19056867    
Organism Homo sapiens
Experiment description Large-scale proteomics and phosphoproteomics of urinary exosomes.
Authors "Gonzales PA, Pisitkun T, Hoffert JD, Tchapyjnikov D, Star RA, Kleta R, Wang NS, Knepper MA"
Journal name JASN
Publication year 2009
Sample Urine
Sample name Urine - Normal
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [LTQ]
Western blotting
3
Experiment ID 193
MISEV standards
EM
Biophysical techniques
CD63|CD9
Enriched markers
PHB
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 21595033    
Organism Homo sapiens
Experiment description Proteomic analysis of urinary exosomes from patients of early IgA nephropathy and thin basement membrane nephropathy.
Authors "Moon PG, Lee JE, You S, Kim TK, Cho JH, Kim IS, Kwon TH, Kim CD, Park SH, Hwang D, Kim YL, Baek MC."
Journal name Proteomics
Publication year 2011
Sample Urine
Sample name Urine - Normal
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
4
Experiment ID 194
MISEV standards
Biophysical techniques
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 21595033    
Organism Homo sapiens
Experiment description Proteomic analysis of urinary exosomes from patients of early IgA nephropathy and thin basement membrane nephropathy.
Authors "Moon PG, Lee JE, You S, Kim TK, Cho JH, Kim IS, Kwon TH, Kim CD, Park SH, Hwang D, Kim YL, Baek MC."
Journal name Proteomics
Publication year 2011
Sample Urine
Sample name Urine - Patients of basement membrane nephropathy
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
5
Experiment ID 195
MISEV standards
Biophysical techniques
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 21595033    
Organism Homo sapiens
Experiment description Proteomic analysis of urinary exosomes from patients of early IgA nephropathy and thin basement membrane nephropathy.
Authors "Moon PG, Lee JE, You S, Kim TK, Cho JH, Kim IS, Kwon TH, Kim CD, Park SH, Hwang D, Kim YL, Baek MC."
Journal name Proteomics
Publication year 2011
Sample Urine
Sample name Urine - Patients of early IgA nephropathy
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for C11orf54
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 TRIP13 9319
Two-hybrid Homo sapiens
2 NSFL1C 55968
Co-fractionation Homo sapiens
3 GSTO1 9446
Co-fractionation Homo sapiens
4 DCXR 51181
Co-fractionation Homo sapiens
5 SERPINB3 6317
Co-fractionation Homo sapiens
6 CCT3 7203
Affinity Capture-MS Homo sapiens
7 SOD1 6647
Co-fractionation Homo sapiens
8 WDR1 9948
Co-fractionation Homo sapiens
9 CCT2 10576
Affinity Capture-MS Homo sapiens
10 VAC14 55697
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
11 CCT6A 908
Affinity Capture-MS Homo sapiens
12 PPA1 5464
Co-fractionation Homo sapiens
13 ANXA7 310
Co-fractionation Homo sapiens
14 SDF2 6388
Co-fractionation Homo sapiens
15 TKT 7086
Co-fractionation Homo sapiens
16 PIR 8544
Co-fractionation Homo sapiens
17 PEBP1 5037
Co-fractionation Homo sapiens
18 PCMT1 5110
Co-fractionation Homo sapiens
19 SERPINB5 5268
Co-fractionation Homo sapiens
20 APP 351
Reconstituted Complex Homo sapiens
21 AKR1C2  
Co-fractionation Homo sapiens
22 ANXA11 311
Co-fractionation Homo sapiens
23 PGM2 55276
Co-fractionation Homo sapiens
24 GNPDA2 132789
Co-fractionation Homo sapiens
25 PRDX6 9588
Co-fractionation Homo sapiens
26 RPL7A 6130
Cross-Linking-MS (XL-MS) Homo sapiens
27 BCAT2 587
Co-fractionation Homo sapiens
28 TPI1 7167
Co-fractionation Homo sapiens
29 GOT1 2805
Co-fractionation Homo sapiens
30 YKT6 10652
Co-fractionation Homo sapiens
31 FH 2271
Co-fractionation Homo sapiens
32 COA7  
Affinity Capture-MS Homo sapiens
33 AKR1A1 10327
Co-fractionation Homo sapiens
34 FKBP2 2286
Co-fractionation Homo sapiens
35 CUL4A 8451
Affinity Capture-MS Homo sapiens
36 SSX2IP  
Two-hybrid Homo sapiens
View the network image/svg+xml
 Pathways in which C11orf54 is involved
No pathways found





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