Gene description for CXCL1
Gene name chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
Gene symbol CXCL1
Other names/aliases FSP
GRO1
GROa
MGSA
MGSA-a
NAP-3
SCYB1
Species Homo sapiens
 Database cross references - CXCL1
ExoCarta ExoCarta_2919
Vesiclepedia VP_2919
Entrez Gene 2919
HGNC 4602
MIM 155730
UniProt P09341  
 CXCL1 identified in sEVs derived from the following tissue/cell type
Plasma 34112803    
 Gene ontology annotations for CXCL1
Molecular Function
    signaling receptor binding GO:0005102 TAS
    protein binding GO:0005515 IPI
    enzyme activator activity GO:0008047 TAS
    growth factor activity GO:0008083 TAS
Biological Process
    chemotaxis GO:0006935 TAS
    signal transduction GO:0007165 TAS
    G protein-coupled receptor signaling pathway GO:0007186 TAS
    nervous system development GO:0007399 TAS
    negative regulation of cell population proliferation GO:0008285 TAS
    actin cytoskeleton organization GO:0030036 TAS
    killing of cells of another organism GO:0031640 IDA
    intracellular signal transduction GO:0035556 TAS
    antimicrobial humoral immune response mediated by antimicrobial peptide GO:0061844 IDA
Subcellular Localization
    extracellular region GO:0005576 TAS
    specific granule lumen GO:0035580 TAS
    tertiary granule lumen GO:1904724 TAS
 Experiment description of studies that identified CXCL1 in sEVs
1
Experiment ID 525
MISEV standards
EM
Biophysical techniques
Enriched markers
Negative markers
NTA
Particle analysis
Identified molecule protein
Identification method ELISA
PubMed ID 34112803    
Organism Homo sapiens
Experiment description Tumor microenvironmental cytokines bound to cancer exosomes determine uptake by cytokine receptor-expressing cells and biodistribution
Authors "Lima LG, Ham S, Shin H, Chai EPZ, Lek ESH, Lobb RJ, Müller AF, Mathivanan S, Yeo B, Choi Y, Parker BS, Möller A. "
Journal name Nat Commun
Publication year 2021
Sample Plasma
Sample name Pooled plasma from healthy subjects
Isolation/purification methods Size exclusion chromatography
Centrifugal ultrafiltration
Flotation density -
Molecules identified in the study Protein
Methods used in the study ELISA
 Protein-protein interactions for CXCL1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 MEOX2  
Two-hybrid Homo sapiens
2 CXCL1 2919
Co-crystal Structure Homo sapiens
Co-crystal Structure Homo sapiens
3 CXCL2 2920
Affinity Capture-MS Homo sapiens
4 CXCL5  
Reconstituted Complex Homo sapiens
5 SRSF1 6426
Affinity Capture-RNA Homo sapiens
6 BIRC2  
Affinity Capture-MS Homo sapiens
7 DIABLO 56616
Affinity Capture-MS Homo sapiens
8 SEH1L 81929
Affinity Capture-MS Homo sapiens
9 CXCL3  
Affinity Capture-MS Homo sapiens
10 CCL11  
Reconstituted Complex Homo sapiens
11 XIAP  
Affinity Capture-MS Homo sapiens
12 TRAF2 7186
Affinity Capture-MS Homo sapiens
13 TBK1 29110
Affinity Capture-MS Homo sapiens
14 HIPK2 28996
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
15 CXCL6  
Reconstituted Complex Homo sapiens
16 ACKR1  
Reconstituted Complex Homo sapiens
17 BIRC6 57448
Affinity Capture-MS Homo sapiens
View the network image/svg+xml



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