Gene description for HIPK2
Gene name	homeodomain interacting protein kinase 2
Gene symbol	HIPK2
Other names/aliases	PRO0593
Species	Homo sapiens
Database cross references - HIPK2
ExoCarta	ExoCarta_28996
Vesiclepedia	VP_28996
Entrez Gene	28996
HGNC	14402
MIM	606868
UniProt	Q9H2X6
HIPK2 identified in sEVs derived from the following tissue/cell type
Endothelial cells	26027894

Gene ontology annotations for HIPK2

Molecular Function     transcription coactivator activity GO:0003713 IBA     transcription coactivator activity GO:0003713 ISS     transcription corepressor activity GO:0003714 IBA     transcription corepressor activity GO:0003714 IDA     protein kinase activity GO:0004672 IDA     protein serine/threonine kinase activity GO:0004674 IBA     protein serine/threonine kinase activity GO:0004674 IDA     protein serine/threonine kinase activity GO:0004674 ISS     protein serine/threonine kinase activity GO:0004674 TAS     3-phosphoinositide-dependent protein kinase activity GO:0004676 IEA     DNA-dependent protein kinase activity GO:0004677 IEA     AMP-activated protein kinase activity GO:0004679 IEA     eukaryotic translation initiation factor 2alpha kinase activity GO:0004694 IEA     ribosomal protein S6 kinase activity GO:0004711 IEA     protein tyrosine kinase activity GO:0004713 IBA     protein binding GO:0005515 IPI     ATP binding GO:0005524 IEA     histone H3S10 kinase activity GO:0035175 IEA     histone H3T11 kinase activity GO:0035402 IEA     histone H3T6 kinase activity GO:0035403 IEA     histone H2AXS139 kinase activity GO:0035979 IEA     histone H3S28 kinase activity GO:0044022 IEA     histone H4S1 kinase activity GO:0044023 IEA     histone H2AS1 kinase activity GO:0044024 IEA     histone H2BS14 kinase activity GO:0044025 IEA     SMAD binding GO:0046332 IBA     SMAD binding GO:0046332 IPI     virion binding GO:0046790 IPI     RNA polymerase II-specific DNA-binding transcription factor binding GO:0061629 IPI     RNA polymerase II-specific DNA-binding transcription factor binding GO:0061629 ISS     histone H3T3 kinase activity GO:0072354 IEA     histone H2AS121 kinase activity GO:0072371 IEA     Rho-dependent protein serine/threonine kinase activity GO:0072518 IEA     protein serine kinase activity GO:0106310 IEA     histone H2BS36 kinase activity GO:0140823 IEA     histone H3S57 kinase activity GO:0140855 IEA     histone H3T45 kinase activity GO:0140857 IEA     histone H2AT120 kinase activity GO:1990244 IEA Biological Process     negative regulation of transcription by RNA polymerase II GO:0000122 IEA     eye development GO:0001654 ISS     respiratory system process GO:0003016 IEA     protein phosphorylation GO:0006468 IDA     transforming growth factor beta receptor signaling pathway GO:0007179 IEA     smoothened signaling pathway GO:0007224 IBA     adult walking behavior GO:0007628 IEA     cell population proliferation GO:0008283 IEA     positive regulation of cell population proliferation GO:0008284 IEA     anterior/posterior pattern specification GO:0009952 IEA     gene expression GO:0010467 IEA     retina layer formation GO:0010842 IEA     peptidyl-serine phosphorylation GO:0018105 IDA     peptidyl-serine phosphorylation GO:0018105 ISS     peptidyl-threonine phosphorylation GO:0018107 ISS     neuron differentiation GO:0030182 IEA     erythrocyte differentiation GO:0030218 ISS     DNA damage response, signal transduction by p53 class mediator GO:0030330 IDA     positive regulation of transforming growth factor beta receptor signaling pathway GO:0030511 IMP     negative regulation of BMP signaling pathway GO:0030514 IMP     PML body organization GO:0030578 TAS     thyroid gland development GO:0030878 IEA     positive regulation of protein binding GO:0032092 ISS     epigenetic regulation of gene expression GO:0040029 TAS     intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator GO:0042771 IBA     intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator GO:0042771 TAS     negative regulation of neuron apoptotic process GO:0043524 IEA     positive regulation of angiogenesis GO:0045766 IDA     positive regulation of transcription by RNA polymerase II GO:0045944 IBA     positive regulation of transcription by RNA polymerase II GO:0045944 IMP     positive regulation of transcription by RNA polymerase II GO:0045944 ISS     positive regulation of JNK cascade GO:0046330 IMP     embryonic camera-type eye morphogenesis GO:0048596 IEA     voluntary musculoskeletal movement GO:0050882 IEA     positive regulation of DNA-binding transcription factor activity GO:0051091 ISS     neuron apoptotic process GO:0051402 IEA     regulation of cell cycle GO:0051726 TAS     embryonic retina morphogenesis in camera-type eye GO:0060059 IEA     lens induction in camera-type eye GO:0060235 IEA     SMAD protein signal transduction GO:0060395 IDA     lung morphogenesis GO:0060425 IEA     iris morphogenesis GO:0061072 IEA     cellular response to hypoxia GO:0071456 TAS     intrinsic apoptotic signaling pathway GO:0097193 NAS     regulation of signal transduction by p53 class mediator GO:1901796 TAS     negative regulation of ubiquitin-dependent protein catabolic process GO:2000059 IMP Subcellular Localization     nucleus GO:0005634 IBA     nucleus GO:0005634 IDA     nucleoplasm GO:0005654 IDA     nucleoplasm GO:0005654 TAS     cytoplasm GO:0005737 IBA     cytoplasm GO:0005737 IDA     cytoplasm GO:0005737 ISS     cytoplasmic stress granule GO:0010494 IDA     nuclear body GO:0016604 IDA     nuclear body GO:0016604 TAS     PML body GO:0016605 IBA     PML body GO:0016605 IDA     RNA polymerase II transcription regulator complex GO:0090575 ISS