Gene description for SMAD2
Gene name	SMAD family member 2
Gene symbol	SMAD2
Other names/aliases	JV18 JV18-1 MADH2 MADR2 hMAD-2 hSMAD2
Species	Homo sapiens
Database cross references - SMAD2
ExoCarta	ExoCarta_4087
Vesiclepedia	VP_4087
Entrez Gene	4087
HGNC	6768
MIM	601366
UniProt	Q15796
SMAD2 identified in sEVs derived from the following tissue/cell type
Hepatocytes	26054723
Thymus	23844026

Gene ontology annotations for SMAD2

Molecular Function     RNA polymerase II cis-regulatory region sequence-specific DNA binding GO:0000978 IBA     RNA polymerase II cis-regulatory region sequence-specific DNA binding GO:0000978 IDA     DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981 IBA     DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981 ISA     cis-regulatory region sequence-specific DNA binding GO:0000987 IC     DNA-binding transcription activator activity, RNA polymerase II-specific GO:0001228 IDA     DNA-binding transcription activator activity, RNA polymerase II-specific GO:0001228 ISS     DNA binding GO:0003677 IDA     chromatin binding GO:0003682 IEA     double-stranded DNA binding GO:0003690 ISS     DNA-binding transcription factor activity GO:0003700 IDA     DNA-binding transcription factor activity GO:0003700 IDA     transforming growth factor beta receptor binding GO:0005160 IPI     protein binding GO:0005515 IPI     phosphatase binding GO:0019902 IPI     ubiquitin protein ligase binding GO:0031625 IPI     type I transforming growth factor beta receptor binding GO:0034713 IPI     identical protein binding GO:0042802 IPI     SMAD binding GO:0046332 IPI     metal ion binding GO:0046872 IEA     tau protein binding GO:0048156 ISS     RNA polymerase II-specific DNA-binding transcription factor binding GO:0061629 IEA     co-SMAD binding GO:0070410 IPI     I-SMAD binding GO:0070411 IBA     I-SMAD binding GO:0070411 IPI     R-SMAD binding GO:0070412 IPI     disordered domain specific binding GO:0097718 IPI     DNA-binding transcription factor binding GO:0140297 IPI Biological Process     ureteric bud development GO:0001657 IEA     in utero embryonic development GO:0001701 IEA     endoderm formation GO:0001706 IEA     mesoderm formation GO:0001707 ISS     determination of left/right asymmetry in lateral mesoderm GO:0003140 IMP     aortic valve morphogenesis GO:0003180 ISS     pulmonary valve morphogenesis GO:0003184 ISS     endocardial cushion morphogenesis GO:0003203 ISS     DNA-templated transcription GO:0006351 NAS     regulation of DNA-templated transcription GO:0006355 NAS     transforming growth factor beta receptor signaling pathway GO:0007179 IBA     transforming growth factor beta receptor signaling pathway GO:0007179 IDA     transforming growth factor beta receptor signaling pathway GO:0007179 IMP     transforming growth factor beta receptor signaling pathway GO:0007179 NAS     zygotic specification of dorsal/ventral axis GO:0007352 IMP     gastrulation GO:0007369 TAS     cell population proliferation GO:0008283 IEA     negative regulation of cell population proliferation GO:0008285 IEA     anatomical structure morphogenesis GO:0009653 IBA     post-embryonic development GO:0009791 IEA     anterior/posterior pattern specification GO:0009952 ISS     positive regulation of gene expression GO:0010628 IEA     positive regulation of epithelial to mesenchymal transition GO:0010718 ISS     regulation of transforming growth factor beta receptor signaling pathway GO:0017015 IMP     signal transduction involved in regulation of gene expression GO:0023019 IEA     insulin secretion GO:0030073 IEA     cell differentiation GO:0030154 IBA     negative regulation of ossification GO:0030279 IDA     lung development GO:0030324 IEA     adrenal gland development GO:0030325 IEA     positive regulation of BMP signaling pathway GO:0030513 IMP     pancreas development GO:0031016 IEA     primary miRNA processing GO:0031053 TAS     activin receptor signaling pathway GO:0032924 IBA     activin receptor signaling pathway GO:0032924 IMP     activin receptor signaling pathway GO:0032924 NAS     organ growth GO:0035265 IEA     intracellular signal transduction GO:0035556 ISS     nodal signaling pathway GO:0038092 IMP     cell fate commitment GO:0045165 ISS     negative regulation of DNA-templated transcription GO:0045892 IMP     positive regulation of DNA-templated transcription GO:0045893 IDA     positive regulation of DNA-templated transcription GO:0045893 IMP     positive regulation of DNA-templated transcription GO:0045893 ISS     positive regulation of transcription by RNA polymerase II GO:0045944 IBA     positive regulation of transcription by RNA polymerase II GO:0045944 IDA     positive regulation of transcription by RNA polymerase II GO:0045944 ISS     paraxial mesoderm morphogenesis GO:0048340 ISS     embryonic foregut morphogenesis GO:0048617 IEA     embryonic cranial skeleton morphogenesis GO:0048701 IEA     regulation of binding GO:0051098 ISS     pericardium development GO:0060039 IEA     SMAD protein signal transduction GO:0060395 IBA     SMAD protein signal transduction GO:0060395 IDA     SMAD protein signal transduction GO:0060395 IDA     SMAD protein signal transduction GO:0060395 IMP     secondary palate development GO:0062009 ISS     response to cholesterol GO:0070723 IDA     cellular response to glucose stimulus GO:0071333 IEA     odontoblast differentiation GO:0071895 ISS Subcellular Localization     chromatin GO:0000785 IDA     chromatin GO:0000785 ISA     nucleus GO:0005634 IDA     nucleoplasm GO:0005654 TAS     transcription regulator complex GO:0005667 IDA     cytoplasm GO:0005737 IDA     cytosol GO:0005829 TAS     activin responsive factor complex GO:0032444 IDA     protein-containing complex GO:0032991 IMP     SMAD protein complex GO:0071141 IDA     homomeric SMAD protein complex GO:0071142 IPI     heteromeric SMAD protein complex GO:0071144 IBA     heteromeric SMAD protein complex GO:0071144 IDA     heteromeric SMAD protein complex GO:0071144 IPI     heteromeric SMAD protein complex GO:0071144 NAS