Gene description for RIN1
Gene name Ras and Rab interactor 1
Gene symbol RIN1
Other names/aliases -
Species Homo sapiens
 Database cross references - RIN1
ExoCarta ExoCarta_9610
Vesiclepedia VP_9610
Entrez Gene 9610
HGNC 18749
MIM 605965
UniProt Q13671  
 RIN1 identified in sEVs derived from the following tissue/cell type
Mesenchymal stem cells 36408942    
 Gene ontology annotations for RIN1
Molecular Function
    guanyl-nucleotide exchange factor activity GO:0005085 IBA
    GTPase activator activity GO:0005096 IEA
    protein binding GO:0005515 IPI
    small GTPase binding GO:0031267 IBA
Biological Process
    endocytosis GO:0006897 IEA
    signal transduction GO:0007165 IEA
Subcellular Localization
    cytoplasm GO:0005737 IDA
    cytosol GO:0005829 IBA
    cytosol GO:0005829 TAS
    cytoskeleton GO:0005856 IEA
    plasma membrane GO:0005886 IDA
    endocytic vesicle GO:0030139 IBA
 Experiment description of studies that identified RIN1 in sEVs
1
Experiment ID 488
MISEV standards
✔
EM
Biophysical techniques
✔
CD9|CD81|CD63|GAPDH|SDCBP|LAMP1|TFRC|UCHL1|FLOT2|LAMP2|FLOT1|ICAM1|RAB5B|CD151|RAB35|TSG101|RAB5A|CD82
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for RIN1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 YWHAH 7533
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
2 PSG11  
Affinity Capture-MS Homo sapiens
3 RRAS 6237
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
4 RAP2B 5912
Affinity Capture-MS Homo sapiens
5 YWHAG 7532
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
6 ZWINT  
Affinity Capture-MS Homo sapiens
7 ANKS1B 56899
Two-hybrid Homo sapiens
8 ISCA1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
9 TRAK2 66008
Affinity Capture-MS Homo sapiens
10 ABL2  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
11 NPAS1  
Affinity Capture-MS Homo sapiens
12 ERBB2 2064
Protein-peptide Homo sapiens
13 NPRL2  
Affinity Capture-MS Homo sapiens
14 YPEL3  
Affinity Capture-MS Homo sapiens
15 CAPNS2 84290
Two-hybrid Homo sapiens
16 MDFI  
Two-hybrid Homo sapiens
17 RALGDS  
Two-hybrid Homo sapiens
18 RB1 5925
Negative Genetic Homo sapiens
19 CRACR2B  
Two-hybrid Homo sapiens
20 RAB5A 5868
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
21 B4GALT2  
Affinity Capture-MS Homo sapiens
22 GOLGA6L9  
Two-hybrid Homo sapiens
23 KLHL29  
Affinity Capture-MS Homo sapiens
24 YWHAE 7531
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
25 SEC23B 10483
Two-hybrid Homo sapiens
26 TRIM27  
Two-hybrid Homo sapiens
27 ABL1 25
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
28 KRT34  
Two-hybrid Homo sapiens
29 DPP8 54878
Affinity Capture-MS Homo sapiens
30 SSSCA1 10534
Affinity Capture-MS Homo sapiens
31 HMG20A  
Two-hybrid Homo sapiens
32 HRAS 3265
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
33 YWHAZ 7534
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
34 TRIM7  
Two-hybrid Homo sapiens
35 LZTS2 84445
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
36 PLEKHG4  
Two-hybrid Homo sapiens
37 EGFR 1956
Affinity Capture-Western Homo sapiens
38 EIF3F 8665
Two-hybrid Homo sapiens
39 TSC1 7248
Two-hybrid Homo sapiens
40 ERBB3 2065
Protein-peptide Homo sapiens
41 KLHL34  
Affinity Capture-MS Homo sapiens
42 ANKS1A 23294
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
43 DCTN3 11258
Affinity Capture-MS Homo sapiens
44 GOLGA2 2801
Two-hybrid Homo sapiens
45 GSTM3 2947
Affinity Capture-MS Homo sapiens
46 RRAS2 22800
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
47 CRYBB3  
Affinity Capture-MS Homo sapiens
48 KRTAP15-1  
Two-hybrid Homo sapiens
49 C12orf74  
Affinity Capture-MS Homo sapiens
50 NRAS 4893
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
51 MLLT4 4301
Two-hybrid Homo sapiens
52 INF2 64423
Affinity Capture-MS Homo sapiens
53 SNX17 9784
Two-hybrid Homo sapiens
54 TRIM23 373
Two-hybrid Homo sapiens
55 NT5C 30833
Affinity Capture-MS Homo sapiens
56 RFXANK  
Affinity Capture-MS Homo sapiens
57 PPARD  
Affinity Capture-MS Homo sapiens
58 CCM2 83605
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
59 STAM2 10254
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
60 TRIP10 9322
Two-hybrid Homo sapiens
61 TRAF2 7186
Two-hybrid Homo sapiens
62 SORBS3 10174
Two-hybrid Homo sapiens
63 SMAD2 4087
Affinity Capture-MS Homo sapiens
64 KRAS 3845
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
65 UBXN6 80700
Affinity Capture-MS Homo sapiens
66 CALCOCO2  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
67 HSF2BP  
Two-hybrid Homo sapiens
68 SPRED1 161742
Two-hybrid Homo sapiens
69 SH3RF1  
Two-hybrid Homo sapiens
70 KLHL12  
Two-hybrid Homo sapiens
71 RAB5B 5869
Two-hybrid Homo sapiens
72 DNAI2  
Affinity Capture-MS Homo sapiens
73 HSPB8 26353
Affinity Capture-MS Homo sapiens
74 SOHLH1  
Affinity Capture-MS Homo sapiens
75 METTL21B  
Affinity Capture-MS Homo sapiens
76 COMT 1312
Affinity Capture-MS Homo sapiens
77 ZBED1  
Two-hybrid Homo sapiens
78 USP32 84669
Affinity Capture-MS Homo sapiens
79 AMZ1  
Affinity Capture-MS Homo sapiens
View the network image/svg+xml



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