Gene description for SPRED1
Gene name	sprouty-related, EVH1 domain containing 1
Gene symbol	SPRED1
Other names/aliases	NFLS PPP1R147 hSpred1 spred-1
Species	Homo sapiens
Database cross references - SPRED1
ExoCarta	ExoCarta_161742
Vesiclepedia	VP_161742
Entrez Gene	161742
HGNC	20249
MIM	609291
UniProt	Q7Z699
SPRED1 identified in sEVs derived from the following tissue/cell type
Endothelial cells	26027894

Gene ontology annotations for SPRED1

Molecular Function     stem cell factor receptor binding GO:0005173 ISS     protein binding GO:0005515 IPI     protein kinase binding GO:0019901 IBA     protein kinase binding GO:0019901 IPI     phosphatase binding GO:0019902 IDA     protein serine/threonine kinase inhibitor activity GO:0030291 ISS Biological Process     negative regulation of protein kinase activity GO:0006469 IDA     negative regulation of epithelial to mesenchymal transition GO:0010719 ISS     negative regulation of peptidyl-threonine phosphorylation GO:0010801 IMP     negative regulation of angiogenesis GO:0016525 IMP     negative regulation of transforming growth factor beta receptor signaling pathway GO:0030512 ISS     regulation of MAPK cascade GO:0043408 TAS     negative regulation of MAPK cascade GO:0043409 IMP     positive regulation of DNA damage response, signal transduction by p53 class mediator GO:0043517 ISS     vasculogenesis involved in coronary vascular morphogenesis GO:0060979 IMP     negative regulation of ERK1 and ERK2 cascade GO:0070373 IBA     negative regulation of ERK1 and ERK2 cascade GO:0070373 ISS     negative regulation of cell migration involved in sprouting angiogenesis GO:0090051 IEA     regulation of protein deacetylation GO:0090311 ISS     negative regulation of lens fiber cell differentiation GO:1902747 ISS Subcellular Localization     nucleoplasm GO:0005654 IDA     cytosol GO:0005829 IDA     cytosol GO:0005829 TAS     plasma membrane GO:0005886 IBA     plasma membrane GO:0005886 ISS     plasma membrane GO:0005886 TAS     caveola GO:0005901 IEA     cytoplasmic vesicle GO:0031410 IDA