Gene description for GTF2H1
Gene name general transcription factor IIH, polypeptide 1, 62kDa
Gene symbol GTF2H1
Other names/aliases BTF2
P62
TFB1
TFIIH
Species Homo sapiens
 Database cross references - GTF2H1
ExoCarta ExoCarta_2965
Vesiclepedia VP_2965
Entrez Gene 2965
HGNC 4655
MIM 189972
UniProt P32780  
 GTF2H1 identified in sEVs derived from the following tissue/cell type
Hepatocellular carcinoma cells 26054723    
 Gene ontology annotations for GTF2H1
Molecular Function
    chromatin binding GO:0003682 IEA
    protein binding GO:0005515 IPI
    nuclear thyroid hormone receptor binding GO:0046966 IPI
Biological Process
    regulation of cyclin-dependent protein serine/threonine kinase activity GO:0000079 TAS
    DNA repair GO:0006281 IBA
    nucleotide-excision repair GO:0006289 IEA
    transcription by RNA polymerase I GO:0006360 IBA
    transcription by RNA polymerase II GO:0006366 IBA
    transcription by RNA polymerase II GO:0006366 IDA
    transcription initiation at RNA polymerase II promoter GO:0006367 IDA
    hormone-mediated signaling pathway GO:0009755 NAS
    positive regulation of DNA-templated transcription GO:0045893 IDA
Subcellular Localization
    transcription factor TFIIH core complex GO:0000439 IBA
    transcription factor TFIIH core complex GO:0000439 IDA
    nucleoplasm GO:0005654 IDA
    nucleoplasm GO:0005654 TAS
    transcription factor TFIIH holo complex GO:0005675 IBA
    transcription factor TFIIH holo complex GO:0005675 IDA
 Experiment description of studies that identified GTF2H1 in sEVs
1
Experiment ID 235
MISEV standards
EM
Biophysical techniques
TSG101|Alix|HSC70|GAPDH
Enriched markers
HSP90B1
Negative markers
qNano
Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors "He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N"
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocellular carcinoma cells
Sample name HKCI-8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RT-PCR
RNA Sequencing
 Protein-protein interactions for GTF2H1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 POLR2C 5432
Affinity Capture-MS Homo sapiens
2 SLFN11 91607
Affinity Capture-MS Homo sapiens
3 RIT1 6016
Negative Genetic Homo sapiens
4 GTF2F1 2962
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
5 ACTN1 87
Two-hybrid Homo sapiens
6 TNIP1 10318
Two-hybrid Homo sapiens
7 CCSER2 54462
Two-hybrid Homo sapiens
8 FGL1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
9 KPNA3 3839
Two-hybrid Homo sapiens
10 RNF11 26994
Affinity Capture-MS Homo sapiens
11 REEP5 7905
Two-hybrid Homo sapiens
12 CDK7 1022
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Co-purification Homo sapiens
Co-purification Homo sapiens
13 XPA  
Affinity Capture-Western Homo sapiens
14 RAD23A 5886
Reconstituted Complex Homo sapiens
15 FHL2 2274
Two-hybrid Homo sapiens
16 TP53 7157
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Co-crystal Structure Homo sapiens
17 ESR1  
Biochemical Activity Homo sapiens
Reconstituted Complex Homo sapiens
18 HOXC11  
Two-hybrid Homo sapiens
19 ERCC2 2068
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
20 XPC  
Affinity Capture-Western Homo sapiens
21 RB1 5925
Co-fractionation Homo sapiens
22 TXNRD2 10587
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
23 RPA2 6118
Proximity Label-MS Homo sapiens
Affinity Capture-Western Homo sapiens
24 BRPF1  
Two-hybrid Homo sapiens
25 ZSCAN1  
Two-hybrid Homo sapiens
26 E2F1 1869
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
27 BRD2  
Affinity Capture-MS Homo sapiens
28 RAD23B 5887
Affinity Capture-Western Homo sapiens
29 CD6 923
Affinity Capture-MS Homo sapiens
30 ERCC4  
Affinity Capture-Western Homo sapiens
31 PRDM11  
Affinity Capture-MS Homo sapiens
32 MCC 4163
Affinity Capture-MS Homo sapiens
33 LZTS2 84445
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
34 UBC 7316
Reconstituted Complex Homo sapiens
35 CCNH  
Co-purification Homo sapiens
Co-purification Homo sapiens
Affinity Capture-Western Homo sapiens
36 GTF2H5  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
37 ERCC1  
Affinity Capture-Western Homo sapiens
38 PRPS1 5631
Affinity Capture-MS Homo sapiens
39 GTF2H2  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Co-purification Homo sapiens
Two-hybrid Homo sapiens
Co-fractionation Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-MS Homo sapiens
40 POLR2A 5430
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
41 JDP2  
Two-hybrid Homo sapiens
42 TRIOBP 11078
Two-hybrid Homo sapiens
43 ERCC5  
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
44 TCEA1 6917
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
45 AGTRAP 57085
Two-hybrid Homo sapiens
46 ERCC3  
Co-purification Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-Western Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
47 GTF2H2C  
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
48 UVSSA  
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
49 LRPAP1 4043
Affinity Capture-MS Homo sapiens
50 CETN2 1069
Affinity Capture-MS Homo sapiens
51 MMS19 64210
Affinity Capture-Western Homo sapiens
52 GTF2H3  
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Co-purification Homo sapiens
Co-fractionation Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-MS Homo sapiens
53 MNAT1  
Co-fractionation Homo sapiens
Reconstituted Complex Homo sapiens
Co-purification Homo sapiens
Affinity Capture-MS Homo sapiens
54 FUBP1 8880
Affinity Capture-Western Homo sapiens
55 OGT 8473
Reconstituted Complex Homo sapiens
56 EAF1  
Two-hybrid Homo sapiens
57 TOMM34 10953
Affinity Capture-MS Homo sapiens
58 TTC9C 283237
Affinity Capture-MS Homo sapiens
59 GTF2E1 2960
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
60 GTF2H2C_2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
61 PRMT2  
Affinity Capture-MS Homo sapiens
62 POU2AF1  
Two-hybrid Homo sapiens
63 GTF2H4 2968
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
64 KRAS 3845
Negative Genetic Homo sapiens
65 USHBP1  
Two-hybrid Homo sapiens
66 AR 367
Affinity Capture-Western Homo sapiens
67 RPA1 6117
Affinity Capture-Western Homo sapiens
68 CDC7  
Affinity Capture-MS Homo sapiens
69 SSRP1 6749
Affinity Capture-MS Homo sapiens
70 PSMC2 5701
Affinity Capture-Western Homo sapiens
71 NUDC 10726
Affinity Capture-MS Homo sapiens
72 BRD3 8019
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
73 MAP4K5 11183
Co-fractionation Homo sapiens
74 RXRB 6257
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
75 SMARCC2 6601
Co-fractionation Homo sapiens
View the network image/svg+xml
 Pathways in which GTF2H1 is involved
PathwayEvidenceSource
Disease IEA Reactome
DNA Repair TAS Reactome
Dual Incision in GG-NER TAS Reactome
Dual incision in TC-NER TAS Reactome
Epigenetic regulation of gene expression IEA Reactome
Formation of HIV elongation complex in the absence of HIV Tat IEA Reactome
Formation of HIV-1 elongation complex containing HIV-1 Tat IEA Reactome
Formation of Incision Complex in GG-NER TAS Reactome
Formation of RNA Pol II elongation complex TAS Reactome
Formation of TC-NER Pre-Incision Complex TAS Reactome
Formation of the Early Elongation Complex TAS Reactome
Formation of the HIV-1 Early Elongation Complex IEA Reactome
Gap-filling DNA repair synthesis and ligation in TC-NER TAS Reactome
Gene expression (Transcription) TAS Reactome
Gene expression (Transcription) IEA Reactome
Generic Transcription Pathway TAS Reactome
Global Genome Nucleotide Excision Repair (GG-NER) TAS Reactome
HIV Infection IEA Reactome
HIV Life Cycle IEA Reactome
HIV Transcription Elongation IEA Reactome
HIV Transcription Initiation IEA Reactome
Infectious disease IEA Reactome
Late Phase of HIV Life Cycle IEA Reactome
Metabolism of RNA TAS Reactome
mRNA Capping TAS Reactome
Negative epigenetic regulation of rRNA expression IEA Reactome
NoRC negatively regulates rRNA expression IEA Reactome
Nucleotide Excision Repair TAS Reactome
RNA Pol II CTD phosphorylation and interaction with CE TAS Reactome
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection IEA Reactome
RNA Polymerase I Promoter Clearance TAS Reactome
RNA Polymerase I Promoter Escape TAS Reactome
RNA Polymerase I Transcription TAS Reactome
RNA Polymerase I Transcription Initiation TAS Reactome
RNA Polymerase I Transcription Termination TAS Reactome
RNA Polymerase II HIV Promoter Escape IEA Reactome
RNA Polymerase II Pre-transcription Events TAS Reactome
RNA Polymerase II Promoter Escape TAS Reactome
RNA Polymerase II Transcription TAS Reactome
RNA Polymerase II Transcription Elongation TAS Reactome
RNA Polymerase II Transcription Initiation TAS Reactome
RNA Polymerase II Transcription Initiation And Promoter Clearance TAS Reactome
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening TAS Reactome
Tat-mediated elongation of the HIV-1 transcript IEA Reactome
TP53 Regulates Transcription of DNA Repair Genes TAS Reactome
Transcription of the HIV genome IEA Reactome
Transcription-Coupled Nucleotide Excision Repair (TC-NER) TAS Reactome
Transcriptional Regulation by TP53 TAS Reactome
Viral Infection Pathways IEA Reactome





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