Gene description for NME7
Gene name NME/NM23 family member 7
Gene symbol NME7
Other names/aliases CFAP67
MN23H7
NDK 7
NDK7
nm23-H7
Species Homo sapiens
 Database cross references - NME7
ExoCarta ExoCarta_29922
Vesiclepedia VP_29922
Entrez Gene 29922
HGNC 20461
MIM 613465
UniProt Q9Y5B8  
 NME7 identified in sEVs derived from the following tissue/cell type
Mesenchymal stem cells 36408942    
 Gene ontology annotations for NME7
Molecular Function
    nucleoside diphosphate kinase activity GO:0004550 IDA
    protein kinase activity GO:0004672 IMP
    protein binding GO:0005515 IPI
    ATP binding GO:0005524 IEA
    3'-5' exonuclease activity GO:0008408 IDA
Biological Process
    epithelial cilium movement involved in extracellular fluid movement GO:0003351 IEA
    GTP biosynthetic process GO:0006183 IEA
    UTP biosynthetic process GO:0006228 IEA
    CTP biosynthetic process GO:0006241 IEA
    determination of left/right symmetry GO:0007368 IEA
    brain development GO:0007420 IEA
    regulation of microtubule nucleation GO:0010968 IMP
    flagellated sperm motility GO:0030317 ISS
    intraciliary transport GO:0042073 IEA
    receptor clustering GO:0043113 IEA
    cellular response to leukemia inhibitory factor GO:1990830 IEA
Subcellular Localization
    gamma-tubulin ring complex GO:0000931 IDA
    extracellular region GO:0005576 IEA
    nucleus GO:0005634 IDA
    cytoplasm GO:0005737 IDA
    centrosome GO:0005813 IBA
    centrosome GO:0005813 IDA
    spindle GO:0005819 IEA
    cytosol GO:0005829 TAS
    axonemal microtubule GO:0005879 IBA
    axonemal microtubule GO:0005879 IDA
    axonemal microtubule GO:0005879 ISS
    plasma membrane GO:0005886 IEA
    cilium GO:0005929 IDA
    ciliary basal body GO:0036064 IEA
    sperm flagellum GO:0036126 ISS
    axonemal A tubule inner sheath GO:0160111 ISS
 Experiment description of studies that identified NME7 in sEVs
1
Experiment ID 488
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✔ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for NME7
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 HNRNPH1 3187
Affinity Capture-RNA Homo sapiens
2 SNX32  
Two-hybrid Homo sapiens
3 CCL3  
Affinity Capture-MS Homo sapiens
4 PAX4  
Two-hybrid Homo sapiens
5 TNIP1 10318
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
6 CCDC88B 283234
Two-hybrid Homo sapiens
7 GATAD2B 57459
Two-hybrid Homo sapiens
8 CASC1  
Two-hybrid Homo sapiens
9 WWP1 11059
Affinity Capture-MS Homo sapiens
10 SYCE1  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
11 ANKK1  
Affinity Capture-MS Homo sapiens
12 REL 5966
Two-hybrid Homo sapiens
13 CCHCR1  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
14 TEKT1  
Two-hybrid Homo sapiens
15 MAP4K4 9448
Two-hybrid Homo sapiens
16 TXNDC12 51060
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
17 TUFT1  
Two-hybrid Homo sapiens
18 Tubgcp6  
Affinity Capture-MS Mus musculus
19 LGALS3BP 3959
Affinity Capture-MS Homo sapiens
20 LRRC27  
Affinity Capture-MS Homo sapiens
21 S100A4 6275
Affinity Capture-MS Homo sapiens
22 NFKBIL1  
Two-hybrid Homo sapiens
23 Mzt2  
Affinity Capture-MS Mus musculus
24 THAP10  
Two-hybrid Homo sapiens
25 KIAA0226  
Two-hybrid Homo sapiens
26 BTRC 8945
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
27 ARHGAP9 64333
Two-hybrid Homo sapiens
28 NIF3L1 60491
Two-hybrid Homo sapiens
29 MZT1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
30 TRIM48  
Two-hybrid Homo sapiens
31 C1orf106  
Affinity Capture-MS Homo sapiens
32 AMOTL2 51421
Two-hybrid Homo sapiens
33 ZNF385C  
Affinity Capture-MS Homo sapiens
34 NAGS  
Affinity Capture-MS Homo sapiens
35 MIB1 57534
Proximity Label-MS Homo sapiens
36 ZNF444  
Affinity Capture-MS Homo sapiens
37 FKBP6  
Two-hybrid Homo sapiens
38 ZNF526  
Two-hybrid Homo sapiens
39 GLIS2  
Two-hybrid Homo sapiens
40 CCDC33 80125
Two-hybrid Homo sapiens
41 BTBD6  
Two-hybrid Homo sapiens
42 TUBGCP4 27229
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
43 DNAJB7  
Affinity Capture-MS Homo sapiens
44 GOLGA2 2801
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
45 ZBTB48  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
46 POU6F2  
Two-hybrid Homo sapiens
47 KIAA1683  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
48 AMPD2 271
Affinity Capture-MS Homo sapiens
49 HAUS8  
Two-hybrid Homo sapiens
50 NT5C 30833
Affinity Capture-MS Homo sapiens
51 ZNF23  
Two-hybrid Homo sapiens
52 SPERT  
Two-hybrid Homo sapiens
53 TCHP  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
54 KRT75 9119
Two-hybrid Homo sapiens
55 MEOX2  
Two-hybrid Homo sapiens
56 YWHAQ 10971
Reconstituted Complex Homo sapiens
57 SCAF11  
Affinity Capture-MS Homo sapiens
58 DDX1 1653
Two-hybrid Homo sapiens
59 CEP72  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
60 LATS2 26524
Proximity Label-MS Homo sapiens
61 HSPA12B 116835
Affinity Capture-MS Homo sapiens
62 C1orf189  
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
63 NAB2 4665
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
64 DISC1 27185
Two-hybrid Homo sapiens
65 PROSER3  
Two-hybrid Homo sapiens
66 TUBGCP5 114791
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
67 MEI4  
Two-hybrid Homo sapiens
68 CDC42EP2  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
69 PCED1B  
Affinity Capture-MS Homo sapiens
70 IKZF3  
Two-hybrid Homo sapiens
71 MZT2B 80097
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
72 C16orf72 29035
Affinity Capture-MS Homo sapiens
73 IKZF1  
Two-hybrid Homo sapiens
74 NT5C2 22978
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
75 NEFL 4747
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
76 SOHLH1  
Affinity Capture-MS Homo sapiens
77 TRIM27  
Two-hybrid Homo sapiens
78 OFD1 8481
Two-hybrid Homo sapiens
79 MYOT  
Two-hybrid Homo sapiens
80 Nedd1  
Affinity Capture-MS Mus musculus
81 PGAM1 5223
Cross-Linking-MS (XL-MS) Homo sapiens
82 EFHC2  
Two-hybrid Homo sapiens
83 LPPR2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
84 ENTHD2  
Two-hybrid Homo sapiens
85 WNT2  
Affinity Capture-MS Homo sapiens
86 FLOT1 10211
Two-hybrid Homo sapiens
87 ZNF263  
Two-hybrid Homo sapiens
88 HUWE1 10075
Affinity Capture-MS Homo sapiens
89 ISY1-RAB43 100534599
Two-hybrid Homo sapiens
90 MED11  
Two-hybrid Homo sapiens
91 PRICKLE3  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
92 KRT18 3875
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
93 PLEKHA4 57664
Affinity Capture-MS Homo sapiens
94 Tubgcp5  
Affinity Capture-MS Mus musculus
95 TUBGCP2 10844
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
96 Tubg1 103733
Affinity Capture-MS Mus musculus
97 SWSAP1  
Affinity Capture-MS Homo sapiens
98 KIAA1598 57698
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
99 PREP 5550
Co-fractionation Homo sapiens
100 TUBG1 7283
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
101 TUBG2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
102 FOSL1  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
103 NME4 4833
Two-hybrid Homo sapiens
104 CDK5RAP2 55755
Affinity Capture-MS Homo sapiens
105 INCA1  
Two-hybrid Homo sapiens
106 TNNI2 7136
Two-hybrid Homo sapiens
107 TUBGCP3 10426
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
108 FAM184A 79632
Proximity Label-MS Homo sapiens
109 CSPP1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
110 SNAPIN 23557
Two-hybrid Homo sapiens
111 DDIT4L  
Two-hybrid Homo sapiens
112 PSMA1 5682
Two-hybrid Homo sapiens
113 MED30  
Two-hybrid Homo sapiens
114 MIF 4282
Affinity Capture-MS Homo sapiens
115 PPP4R1L  
Affinity Capture-MS Homo sapiens
116 ZNF620  
Two-hybrid Homo sapiens
117 TCF4  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
118 GLUL 2752
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
119 NEDD1 121441
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
120 CCDC136  
Two-hybrid Homo sapiens
121 CAPN10  
Affinity Capture-MS Homo sapiens
122 LNX1  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
123 NIN 51199
Proximity Label-MS Homo sapiens
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