Gene description for IFIT1
Gene name interferon-induced protein with tetratricopeptide repeats 1
Gene symbol IFIT1
Other names/aliases C56
G10P1
IFI-56
IFI-56K
IFI56
IFIT-1
IFNAI1
ISG56
P56
RNM561
Species Homo sapiens
 Database cross references - IFIT1
ExoCarta ExoCarta_3434
Vesiclepedia VP_3434
Entrez Gene 3434
HGNC 5407
MIM 147690
UniProt P09914  
 IFIT1 identified in sEVs derived from the following tissue/cell type
Thymus 23844026    
 Gene ontology annotations for IFIT1
Molecular Function
    RNA binding GO:0003723 IBA
    RNA binding GO:0003723 IDA
    protein binding GO:0005515 IPI
Biological Process
    response to virus GO:0009615 IDA
    response to virus GO:0009615 IMP
    intracellular transport of viral protein in host cell GO:0019060 IDA
    negative regulation of protein binding GO:0032091 IDA
    positive regulation of viral genome replication GO:0045070 IDA
    negative regulation of viral genome replication GO:0045071 IMP
    negative regulation of helicase activity GO:0051097 IDA
    defense response to virus GO:0051607 IBA
    cellular response to type I interferon GO:0071357 IDA
    cellular response to exogenous dsRNA GO:0071360 IDA
    antiviral innate immune response GO:0140374 IDA
    antiviral innate immune response GO:0140374 IEP
Subcellular Localization
    cytoplasm GO:0005737 IDA
    cytosol GO:0005829 IBA
    cytosol GO:0005829 IDA
    cytosol GO:0005829 TAS
    host cell GO:0043657 IEA
 Experiment description of studies that identified IFIT1 in sEVs
1
Experiment ID 217
MISEV standards
EM
Biophysical techniques
TSG101|CD81|CD9|CD63
Enriched markers
Negative markers
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23844026    
Organism Homo sapiens
Experiment description Characterization of human thymic exosomes.
Authors "Skogberg G, Gudmundsdottir J, van der Post S, Sandstrom K, Bruhn S, Benson M, Mincheva-Nilsson L, Baranov V, Telemo E, Ekwall O."
Journal name PLoS One
Publication year 2013
Sample Thymus
Sample name Normal-Thymus
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for IFIT1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 SNRPB2 6629
Affinity Capture-MS Homo sapiens
2 YBX1 4904
Affinity Capture-MS Homo sapiens
3 HNRNPC 3183
Affinity Capture-MS Homo sapiens
4 MAVS 57506
Proximity Label-MS Homo sapiens
5 ISG15 9636
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
6 TOE1 114034
Affinity Capture-MS Homo sapiens
7 SNRPE 6635
Affinity Capture-MS Homo sapiens
8 PABPC4 8761
Affinity Capture-MS Homo sapiens
9 IFNA14  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
10 Prkcz  
Affinity Capture-MS Mus musculus
11 NR3C1 2908
Proximity Label-MS Homo sapiens
12 SNRPA1 6627
Affinity Capture-MS Homo sapiens
13 IFNA8  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
14 ANXA1 301
Protein-peptide Homo sapiens
15 SNRPA 6626
Affinity Capture-MS Homo sapiens
16 IFNA10  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
17 IGF2BP1 10642
Affinity Capture-MS Homo sapiens
18 HSP90AB1 3326
Affinity Capture-MS Homo sapiens
19 MCCC1 56922
Affinity Capture-MS Homo sapiens
20 GRPEL1 80273
Affinity Capture-MS Homo sapiens
21 IFIT5 24138
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
22 HSP90AA1 3320
Affinity Capture-MS Homo sapiens
23 S100A7 6278
Affinity Capture-MS Homo sapiens
24 MCCC2 64087
Affinity Capture-MS Homo sapiens
25 SNRPF 6636
Affinity Capture-MS Homo sapiens
26 SNRPD2 6633
Affinity Capture-MS Homo sapiens
27 IFIT1B  
Affinity Capture-MS Homo sapiens
28 PRPS2 5634
Affinity Capture-MS Homo sapiens
29 IFNA5  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
30 Spire2  
Affinity Capture-MS Mus musculus
31 PCCA 5095
Affinity Capture-MS Homo sapiens
32 ACACA 31
Affinity Capture-MS Homo sapiens
33 SNRPB 6628
Affinity Capture-MS Homo sapiens
34 IFNA7  
Affinity Capture-MS Homo sapiens
35 PABPC1 26986
Affinity Capture-MS Homo sapiens
36 NCL 4691
Affinity Capture-MS Homo sapiens
37 SNRPD1 6632
Affinity Capture-MS Homo sapiens
38 PHACTR4 65979
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
39 PC 5091
Affinity Capture-MS Homo sapiens
40 SNRNP70 6625
Affinity Capture-MS Homo sapiens
41 PCCB 5096
Affinity Capture-MS Homo sapiens
42 DCD 117159
Affinity Capture-MS Homo sapiens
43 MOV10 4343
Affinity Capture-MS Homo sapiens
44 SAP25  
Affinity Capture-MS Homo sapiens
45 ACTB 60
Co-fractionation Homo sapiens
46 RPLP1 6176
Affinity Capture-MS Homo sapiens
47 SNRPC 6631
Affinity Capture-MS Homo sapiens
48 IFIT3 3437
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
49 ILF2 3608
Affinity Capture-MS Homo sapiens
50 TFEB  
Affinity Capture-MS Homo sapiens
51 IFNA21  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
52 EIF3E 3646
Affinity Capture-Western Homo sapiens
53 IFIT2 3433
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
54 EP300 2033
Affinity Capture-MS Homo sapiens
55 SNRPD3 6634
Affinity Capture-MS Homo sapiens
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