Gene description for IFNAR2
Gene name interferon (alpha, beta and omega) receptor 2
Gene symbol IFNAR2
Other names/aliases IFN-R
IFN-alpha-REC
IFNABR
IFNARB
Species Homo sapiens
 Database cross references - IFNAR2
ExoCarta ExoCarta_3455
Vesiclepedia VP_3455
Entrez Gene 3455
HGNC 5433
MIM 602376
UniProt P48551  
 IFNAR2 identified in sEVs derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
 Gene ontology annotations for IFNAR2
Molecular Function
    type I interferon receptor activity GO:0004905 IBA
    type I interferon receptor activity GO:0004905 IDA
    protein binding GO:0005515 IPI
    JAK pathway signal transduction adaptor activity GO:0008269 TAS
    protein kinase binding GO:0019901 IPI
    cytokine binding GO:0019955 IPI
    type I interferon binding GO:0019962 IPI
Biological Process
    cell surface receptor signaling pathway GO:0007166 TAS
    cell surface receptor signaling pathway via JAK-STAT GO:0007259 IDA
    response to virus GO:0009615 TAS
    response to interferon-alpha GO:0035455 IDA
    response to interferon-alpha GO:0035455 IMP
    response to interferon-beta GO:0035456 IDA
    response to interferon-beta GO:0035456 IMP
    cellular response to interferon-beta GO:0035458 IDA
    regulation of receptor signaling pathway via JAK-STAT GO:0046425 IEA
    defense response to virus GO:0051607 IMP
    type I interferon-mediated signaling pathway GO:0060337 IBA
    type I interferon-mediated signaling pathway GO:0060337 IDA
    type I interferon-mediated signaling pathway GO:0060337 IMP
    type I interferon-mediated signaling pathway GO:0060337 NAS
    cellular response to virus GO:0098586 NAS
    interleukin-22-mediated signaling pathway GO:0140865 IEA
Subcellular Localization
    extracellular region GO:0005576 IEA
    extracellular space GO:0005615 IDA
    plasma membrane GO:0005886 IBA
    plasma membrane GO:0005886 IDA
    plasma membrane GO:0005886 TAS
 Experiment description of studies that identified IFNAR2 in sEVs
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for IFNAR2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 USP18  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
2 GRAP2 9402
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
3 APEX1 328
Affinity Capture-RNA Homo sapiens
4 PPP1R3B  
Two-hybrid Homo sapiens
5 GNB2L1 10399
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
6 PRKAR2A 5576
Reconstituted Complex Homo sapiens
7 IFNA2  
Reconstituted Complex Homo sapiens
Co-purification Homo sapiens
8 STAT1 6772
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
9 IRF9 10379
Affinity Capture-Western Homo sapiens
10 IFNAR1  
Co-localization Homo sapiens
11 JAK1 3716
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
12 PDLIM1 9124
Affinity Capture-MS Homo sapiens
13 CREBBP  
Affinity Capture-Western Homo sapiens
14 PDE4D  
Affinity Capture-Western Homo sapiens
15 STAT2 6773
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
16 IFNAR2 3455
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
17 MAP3K11 4296
Negative Genetic Homo sapiens
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