Gene description for IGHMBP2
Gene name immunoglobulin mu binding protein 2
Gene symbol IGHMBP2
Other names/aliases CATF1
CMT2S
HCSA
HMN6
SMARD1
SMUBP2
ZFAND7
Species Homo sapiens
 Database cross references - IGHMBP2
ExoCarta ExoCarta_3508
Vesiclepedia VP_3508
Entrez Gene 3508
HGNC 5542
MIM 600502
UniProt P38935  
 IGHMBP2 identified in sEVs derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
 Gene ontology annotations for IGHMBP2
Molecular Function
    tRNA binding GO:0000049 IDA
    DNA binding GO:0003677 IDA
    DNA helicase activity GO:0003678 TAS
    DNA clamp loader activity GO:0003689 IEA
    single-stranded DNA binding GO:0003697 IDA
    RNA binding GO:0003723 IDA
    single-stranded RNA binding GO:0003727 IDA
    protein binding GO:0005515 IPI
    ATP binding GO:0005524 IDA
    ATP-dependent activity, acting on DNA GO:0008094 IDA
    transcription factor binding GO:0008134 IPI
    ATP-dependent activity, acting on RNA GO:0008186 IDA
    zinc ion binding GO:0008270 IEA
    four-way junction helicase activity GO:0009378 IEA
    ATP hydrolysis activity GO:0016887 IDA
    5'-3' RNA helicase activity GO:0032574 IDA
    double-stranded DNA helicase activity GO:0036121 IDA
    identical protein binding GO:0042802 IPI
    ribosome binding GO:0043022 IDA
    5'-3' DNA helicase activity GO:0043139 IBA
    5'-3' DNA helicase activity GO:0043139 IDA
    forked DNA-dependent helicase activity GO:0061749 IEA
    cohesin loader activity GO:0061775 IEA
    chromatin extrusion motor activity GO:0140584 IEA
    ATP-dependent H3-H4 histone complex chaperone activity GO:0140665 IEA
    ATP-dependent H2AZ histone chaperone activity GO:0140849 IEA
    single-stranded 3'-5' DNA helicase activity GO:1990518 IEA
Biological Process
    chromatin remodeling GO:0006338 IEA
    RNA secondary structure unwinding GO:0010501 IDA
    DNA duplex unwinding GO:0032508 IDA
    chromatin looping GO:0140588 IEA
Subcellular Localization
    nucleus GO:0005634 IBA
    nucleus GO:0005634 IDA
    nucleoplasm GO:0005654 IDA
    cytoplasm GO:0005737 IBA
    cytoplasm GO:0005737 IDA
    membrane GO:0016020 HDA
    nuclear body GO:0016604 IDA
    axon GO:0030424 ISS
    growth cone GO:0030426 ISS
    ribonucleoprotein complex GO:1990904 ISS
 Experiment description of studies that identified IGHMBP2 in sEVs
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for IGHMBP2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Kif19a  
Affinity Capture-MS Mus musculus
2 WDR12 55759
Affinity Capture-MS Homo sapiens
3 SURF6  
Affinity Capture-MS Homo sapiens
4 TUBA8 51807
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
5 LSM8 51691
Two-hybrid Homo sapiens
6 NLE1 54475
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
7 NELFCD 51497
Affinity Capture-MS Homo sapiens
8 SMC6  
Affinity Capture-MS Homo sapiens
9 NELFA  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
10 WDR89  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
11 SASS6 163786
Affinity Capture-MS Homo sapiens
12 RPL5 6125
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
13 NELFE 7936
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
14 ARRB1 408
Affinity Capture-MS Homo sapiens
15 HECTD1 25831
Affinity Capture-MS Homo sapiens
16 IFI16 3428
Affinity Capture-MS Homo sapiens
17 GRSF1 2926
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
18 KRAS 3845
Affinity Capture-MS Homo sapiens
19 HNRNPU 3192
Affinity Capture-MS Homo sapiens
20 ARID1A 8289
Affinity Capture-MS Homo sapiens
21 DDRGK1 65992
Affinity Capture-MS Homo sapiens
22 PRKRIR  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which IGHMBP2 is involved
No pathways found





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