Experiment description of studies that identified SASS6 in sEVs

1 Experiment ID 126 MISEV standards ✘ Biophysical techniques ✔ GAPDH Enriched markers ✘ Negative markers ✘ Particle analysis Identified molecule protein Identification method Mass spectrometry [LTQ-FT Ultra] PubMed ID Unpublished / Not applicable Organism Homo sapiens Experiment description Mesenchymal Stem Cell Exosomes: The Future MSC-based Therapy? Authors "Ruenn Chai Lai, Ronne Wee Yeh Yeo, Soon Sim Tan, Bin Zhang, Yijun Yin, Newman Siu Kwan Sze, Andre Choo, and Sai Kiang Lim" Journal name Mesenchymal Stem Cell Therapy Publication year 2011 Sample Mesenchymal stem cells Sample name huES9.E1 Isolation/purification methods HPLC Flotation density - Molecules identified in the study Protein Methods used in the study Western blotting Antobody array Mass spectrometry

2 Experiment ID 193 MISEV standards ✔ EM Biophysical techniques ✔ CD63|CD9 Enriched markers ✔ PHB Negative markers ✘ Particle analysis Identified molecule protein Identification method Mass spectrometry PubMed ID 21595033     Organism Homo sapiens Experiment description Proteomic analysis of urinary exosomes from patients of early IgA nephropathy and thin basement membrane nephropathy. Authors "Moon PG, Lee JE, You S, Kim TK, Cho JH, Kim IS, Kwon TH, Kim CD, Park SH, Hwang D, Kim YL, Baek MC." Journal name Proteomics Publication year 2011 Sample Urine Sample name Urine - Normal Isolation/purification methods Differential centrifugation Ultracentrifugation Sucrose density gradient Flotation density - Molecules identified in the study Protein Methods used in the study Mass spectrometry

3 Experiment ID 194 MISEV standards ✘ Biophysical techniques ✘ Enriched markers ✘ Negative markers ✘ Particle analysis Identified molecule protein Identification method Mass spectrometry PubMed ID 21595033     Organism Homo sapiens Experiment description Proteomic analysis of urinary exosomes from patients of early IgA nephropathy and thin basement membrane nephropathy. Authors "Moon PG, Lee JE, You S, Kim TK, Cho JH, Kim IS, Kwon TH, Kim CD, Park SH, Hwang D, Kim YL, Baek MC." Journal name Proteomics Publication year 2011 Sample Urine Sample name Urine - Patients of basement membrane nephropathy Isolation/purification methods Differential centrifugation Ultracentrifugation Sucrose density gradient Flotation density - Molecules identified in the study Protein Methods used in the study Mass spectrometry

4 Experiment ID 195 MISEV standards ✘ Biophysical techniques ✘ Enriched markers ✘ Negative markers ✘ Particle analysis Identified molecule protein Identification method Mass spectrometry PubMed ID 21595033     Organism Homo sapiens Experiment description Proteomic analysis of urinary exosomes from patients of early IgA nephropathy and thin basement membrane nephropathy. Authors "Moon PG, Lee JE, You S, Kim TK, Cho JH, Kim IS, Kwon TH, Kim CD, Park SH, Hwang D, Kim YL, Baek MC." Journal name Proteomics Publication year 2011 Sample Urine Sample name Urine - Patients of early IgA nephropathy Isolation/purification methods Differential centrifugation Ultracentrifugation Sucrose density gradient Flotation density - Molecules identified in the study Protein Methods used in the study Mass spectrometry

Protein-protein interactions for SASS6

Protein Interactor ExoCarta ID Identification method PubMed Species 1 KRT37 8688 Affinity Capture-MS Homo sapiens 2 DLG5 9231 Proximity Label-MS Homo sapiens 3 TBC1D2 55357 Affinity Capture-MS Homo sapiens 4 CENPE 1062 Proximity Label-MS Homo sapiens 5 NFIB   Affinity Capture-MS Homo sapiens 6 ALMS1   Proximity Label-MS Homo sapiens 7 RABEP2 79874 Affinity Capture-MS Homo sapiens 8 NUP62 23636 Affinity Capture-MS Homo sapiens 9 APC   Proximity Label-MS Homo sapiens 10 EFTUD1 79631 Affinity Capture-MS Homo sapiens 11 TOX3   Proximity Label-MS Homo sapiens 12 KIF7 374654 Proximity Label-MS Homo sapiens 13 CCDC102B   Affinity Capture-MS Homo sapiens 14 CEP97 79598 Proximity Label-MS Homo sapiens 15 DPPA4   Affinity Capture-MS Homo sapiens 16 PCNT   Proximity Label-MS Homo sapiens 17 SYCE3   Affinity Capture-MS Homo sapiens Affinity Capture-MS Homo sapiens 18 IGHMBP2 3508 Affinity Capture-MS Homo sapiens 19 PCGF1 84759 Affinity Capture-MS Homo sapiens 20 CCDC14   Proximity Label-MS Homo sapiens 21 CCDC138   Proximity Label-MS Homo sapiens 22 POU5F1   Affinity Capture-MS Homo sapiens 23 CEP162   Proximity Label-MS Homo sapiens 24 CCDC18   Proximity Label-MS Homo sapiens 25 ATG16L1 55054 Affinity Capture-MS Homo sapiens 26 KRT83   Affinity Capture-MS Homo sapiens 27 TARBP1 6894 Proximity Label-MS Homo sapiens 28 CEP131 22994 Proximity Label-MS Homo sapiens 29 TNFRSF1B   Affinity Capture-MS Homo sapiens 30 N4BP2   Proximity Label-MS Homo sapiens 31 FBXW5   Affinity Capture-Western Homo sapiens Biochemical Activity Homo sapiens Affinity Capture-Western Homo sapiens 32 KIF14 9928 Proximity Label-MS Homo sapiens 33 C15orf59   Affinity Capture-MS Homo sapiens 34 SPAG5 10615 Proximity Label-MS Homo sapiens 35 MIB1 57534 Proximity Label-MS Homo sapiens 36 TMEM126A 84233 Affinity Capture-MS Homo sapiens 37 PIBF1   Proximity Label-MS Homo sapiens 38 CEP192 55125 Proximity Label-MS Homo sapiens 39 TCEAL1   Affinity Capture-MS Homo sapiens Affinity Capture-MS Homo sapiens Affinity Capture-MS Homo sapiens 40 SIPA1L1 26037 Proximity Label-MS Homo sapiens 41 OFD1 8481 Proximity Label-MS Homo sapiens 42 CEP152   Proximity Label-MS Homo sapiens 43 SIPA1L2   Proximity Label-MS Homo sapiens 44 TCHP   Proximity Label-MS Homo sapiens 45 CEP164   Proximity Label-MS Homo sapiens 46 BICD2 23299 Proximity Label-MS Homo sapiens 47 STIL   Affinity Capture-Western Homo sapiens Proximity Label-MS Homo sapiens Affinity Capture-Western Homo sapiens 48 SCOC 60592 Affinity Capture-MS Homo sapiens Affinity Capture-MS Homo sapiens 49 GCSAML   Affinity Capture-MS Homo sapiens 50 RHOT2 89941 Proximity Label-MS Homo sapiens 51 ANKRD26 22852 Proximity Label-MS Homo sapiens 52 CYLD   Proximity Label-MS Homo sapiens 53 FGFR1OP   Proximity Label-MS Homo sapiens 54 RTEL1 51750 Affinity Capture-MS Homo sapiens 55 SSX2IP   Proximity Label-MS Homo sapiens 56 KIZ   Proximity Label-MS Homo sapiens 57 CEP63   Proximity Label-MS Homo sapiens 58 RTN4IP1   Affinity Capture-MS Homo sapiens 59 C11orf49   Proximity Label-MS Homo sapiens 60 FAM21A 387680 Proximity Label-MS Homo sapiens 61 CCP110   Proximity Label-MS Homo sapiens 62 EGFR 1956 Negative Genetic Homo sapiens 63 ZC3HC1   Affinity Capture-MS Homo sapiens Affinity Capture-MS Homo sapiens 64 CTAG2   Affinity Capture-MS Homo sapiens 65 TP73   Affinity Capture-Western Homo sapiens 66 KRT27 342574 Affinity Capture-MS Homo sapiens 67 CDK5RAP2 55755 Proximity Label-MS Homo sapiens 68 LZTS2 84445 Proximity Label-MS Homo sapiens 69 CEP250 11190 Proximity Label-MS Homo sapiens 70 COG6 57511 Affinity Capture-MS Homo sapiens Affinity Capture-MS Homo sapiens 71 CCDC77   Proximity Label-MS Homo sapiens 72 NIN 51199 Proximity Label-MS Homo sapiens Proximity Label-MS Homo sapiens 73 CNTROB   Proximity Label-MS Homo sapiens 74 FCHSD2   Two-hybrid Homo sapiens 75 SEC16A 9919 Proximity Label-MS Homo sapiens 76 TXNL1 9352 Proximity Label-MS Homo sapiens 77 FAM21C 253725 Proximity Label-MS Homo sapiens 78 CGN   Proximity Label-MS Homo sapiens 79 BICD1 636 Proximity Label-MS Homo sapiens 80 PCM1 5108 Proximity Label-MS Homo sapiens 81 NANOG   Affinity Capture-MS Homo sapiens 82 CEP350 9857 Proximity Label-MS Homo sapiens 83 TNRC6B   Proximity Label-MS Homo sapiens 84 ENTHD1   Affinity Capture-MS Homo sapiens 85 MPHOSPH9   Proximity Label-MS Homo sapiens 86 GPT 2875 Affinity Capture-MS Homo sapiens 87 CEP290   Proximity Label-MS Homo sapiens 88 PLEKHA4 57664 Affinity Capture-MS Homo sapiens 89 SEC24A 10802 Proximity Label-MS Homo sapiens 90 LRRC49   Proximity Label-MS Homo sapiens 91 KIAA0753   Proximity Label-MS Homo sapiens 92 RGPD8   Proximity Label-MS Homo sapiens 93 BFSP1   Affinity Capture-MS Homo sapiens 94 CENPJ 55835 Proximity Label-MS Homo sapiens 95 SDCCAG3   Proximity Label-MS Homo sapiens 96 SLC39A7 7922 Affinity Capture-MS Homo sapiens 97 KEAP1 9817 Affinity Capture-MS Homo sapiens 98 SIPA1L3   Proximity Label-MS Homo sapiens 99 SQSTM1 8878 Proximity Label-MS Homo sapiens Proximity Label-MS Homo sapiens 100 FYCO1 79443 Affinity Capture-MS Homo sapiens Affinity Capture-MS Homo sapiens Affinity Capture-MS Homo sapiens 101 CSPP1   Proximity Label-MS Homo sapiens 102 Sass6   Affinity Capture-MS Mus musculus 103 CGNL1   Proximity Label-MS Homo sapiens 104 TRIP11 9321 Proximity Label-MS Homo sapiens 105 AARSD1 80755 Affinity Capture-MS Homo sapiens Affinity Capture-MS Homo sapiens 106 EXOC3L1   Affinity Capture-MS Homo sapiens 107 ABI2 10152 Affinity Capture-MS Homo sapiens Affinity Capture-MS Homo sapiens 108 UBR4 23352 Proximity Label-MS Homo sapiens 109 NEDD1 121441 Proximity Label-MS Homo sapiens 110 CEP135   Proximity Label-MS Homo sapiens 111 C2CD5 9847 Affinity Capture-MS Homo sapiens 112 PRPF4 9128 Affinity Capture-MS Homo sapiens 113 KRAS 3845 Negative Genetic Homo sapiens 114 TNRC6A 27327 Proximity Label-MS Homo sapiens 115 C17orf59 54785 Affinity Capture-MS Homo sapiens Affinity Capture-MS Homo sapiens Affinity Capture-MS Homo sapiens 116 ZNF365   Affinity Capture-MS Homo sapiens View the network

Pathways in which SASS6 is involved

No pathways found