Gene description for SIPA1L1
Gene name signal-induced proliferation-associated 1 like 1
Gene symbol SIPA1L1
Other names/aliases E6TP1
Species Homo sapiens
 Database cross references - SIPA1L1
ExoCarta ExoCarta_26037
Vesiclepedia VP_26037
Entrez Gene 26037
HGNC 20284
UniProt O43166  
 SIPA1L1 identified in sEVs derived from the following tissue/cell type
Mesenchymal stem cells 36408942    
Neuroblastoma cells 25944692    
 Gene ontology annotations for SIPA1L1
Molecular Function
    GTPase activator activity GO:0005096 IBA
    protein binding GO:0005515 IPI
    ephrin receptor binding GO:0046875 IEA
Biological Process
    actin cytoskeleton organization GO:0030036 ISS
    regulation of GTPase activity GO:0043087 ISS
    ephrin receptor signaling pathway GO:0048013 ISS
    regulation of synaptic plasticity GO:0048167 ISS
    regulation of axonogenesis GO:0050770 ISS
    regulation of small GTPase mediated signal transduction GO:0051056 IEA
    regulation of dendritic spine morphogenesis GO:0061001 ISS
    activation of GTPase activity GO:0090630 ISS
Subcellular Localization
    cytoplasm GO:0005737 IBA
    plasma membrane GO:0005886 IDA
    postsynaptic density GO:0014069 ISS
    actin cytoskeleton GO:0015629 IDA
    dendritic spine GO:0043197 ISS
 Experiment description of studies that identified SIPA1L1 in sEVs
1
Experiment ID 488
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✔ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 224
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25944692    
Organism Homo sapiens
Experiment description Proteogenomic analysis reveals exosomes are more oncogenic than ectosomes
Authors "Keerthikumar S, Gangoda L, Liem M, Fonseka P, Atukorala I, Ozcitti C, Mechler A, Adda CG, Ang CS, Mathivanan S"
Journal name Oncotarget
Publication year 2015
Sample Neuroblastoma cells
Sample name SH-SY5Y
Isolation/purification methods Differential centrifugation
Ultracentrifugation
OptiPrep density gradient
Flotation density 1.10 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
Western blotting
 Protein-protein interactions for SIPA1L1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 ACOT7 11332
Affinity Capture-MS Homo sapiens
2 HDAC4  
Affinity Capture-MS Homo sapiens
3 TSSK2  
Co-fractionation Homo sapiens
4 OCLN 100506658
Proximity Label-MS Homo sapiens
5 KSR1  
Affinity Capture-MS Homo sapiens
6 RALGPS2 55103
Affinity Capture-MS Homo sapiens
7 SH3BP4 23677
Affinity Capture-MS Homo sapiens
8 PARD3 56288
Proximity Label-MS Homo sapiens
9 TRIM66  
Affinity Capture-MS Homo sapiens
10 NAV1 89796
Affinity Capture-MS Homo sapiens
11 SPSB4  
Affinity Capture-MS Homo sapiens
12 CDC25B 994
Affinity Capture-MS Homo sapiens
13 SRGAP2 23380
Affinity Capture-MS Homo sapiens
14 USP11 8237
Affinity Capture-MS Homo sapiens
15 WDR83  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
16 CAMSAP2  
Affinity Capture-MS Homo sapiens
17 CBY1  
Affinity Capture-MS Homo sapiens
18 Actb 11461
Affinity Capture-MS Mus musculus
19 EIF4E2  
Affinity Capture-MS Homo sapiens
20 SOX2  
Affinity Capture-MS Homo sapiens
21 LZTS3  
Affinity Capture-MS Homo sapiens
22 CENPU  
Affinity Capture-MS Homo sapiens
23 MLLT4 4301
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
24 DYRK1A 1859
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
25 ZBTB21  
Affinity Capture-MS Homo sapiens
26 ACTR3 10096
Proximity Label-MS Homo sapiens
27 RASAL2 9462
Affinity Capture-MS Homo sapiens
28 ZNF638 27332
Affinity Capture-MS Homo sapiens
29 RAB3IP  
Affinity Capture-MS Homo sapiens
30 IQGAP1 8826
Affinity Capture-MS Homo sapiens
31 YWHAG 7532
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
32 TIAM1  
Affinity Capture-MS Homo sapiens
33 PHLDB2 90102
Affinity Capture-MS Homo sapiens
34 Flot2 14252
Affinity Capture-MS Mus musculus
35 DCLK1 9201
Affinity Capture-MS Homo sapiens
36 PTPN14 5784
Affinity Capture-MS Homo sapiens
37 YWHAH 7533
Affinity Capture-MS Homo sapiens
38 SFN 2810
Affinity Capture-MS Homo sapiens
39 LRFN1  
Affinity Capture-MS Homo sapiens
40 KIAA1804  
Affinity Capture-MS Homo sapiens
41 DYRK1B  
Affinity Capture-MS Homo sapiens
42 YWHAB 7529
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
43 AGAP1  
Affinity Capture-MS Homo sapiens
44 E2F4  
Affinity Capture-MS Homo sapiens
45 KRT8 3856
Proximity Label-MS Homo sapiens
46 CDK16 5127
Affinity Capture-MS Homo sapiens
47 POLD1 5424
Affinity Capture-MS Homo sapiens
48 ANKRD34A  
Affinity Capture-MS Homo sapiens
49 USP21  
Affinity Capture-MS Homo sapiens
50 FKBP6  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
51 FAM110A  
Affinity Capture-MS Homo sapiens
52 TESK2  
Affinity Capture-MS Homo sapiens
53 CEBPE  
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
54 NRXN1  
Two-hybrid Homo sapiens
55 HDAC7  
Affinity Capture-MS Homo sapiens
56 BTF3 689
Affinity Capture-MS Homo sapiens
57 SIPA1L2  
Affinity Capture-MS Homo sapiens
58 LPIN3 64900
Affinity Capture-MS Homo sapiens
59 YWHAQ 10971
Affinity Capture-MS Homo sapiens
60 ACTB 60
Proximity Label-MS Homo sapiens
61 BCL6  
Affinity Capture-MS Homo sapiens
62 FAM110B  
Affinity Capture-MS Homo sapiens
63 TANC2  
Affinity Capture-MS Homo sapiens
64 LATS2 26524
Proximity Label-MS Homo sapiens
65 LARP1 23367
Affinity Capture-MS Homo sapiens
66 LIMA1 51474
Affinity Capture-MS Homo sapiens
67 MRM1  
Affinity Capture-MS Homo sapiens
68 Myh9 17886
Affinity Capture-MS Mus musculus
69 PIP 5304
Affinity Capture-MS Homo sapiens
70 CTNNB1 1499
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
71 OSBPL6  
Affinity Capture-MS Homo sapiens
72 INPP5E 56623
Affinity Capture-MS Homo sapiens
73 SH3RF3  
Affinity Capture-MS Homo sapiens
74 YWHAZ 7534
Affinity Capture-MS Homo sapiens
75 MYO19  
Affinity Capture-MS Homo sapiens
76 DLG4  
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
77 SASS6 163786
Proximity Label-MS Homo sapiens
78 SYDE1 85360
Affinity Capture-MS Homo sapiens
79 PLEKHA5 54477
Affinity Capture-MS Homo sapiens
80 LZTS2 84445
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
81 FBXW11  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
82 SYNPO 11346
Affinity Capture-MS Homo sapiens
83 NADK 65220
Affinity Capture-MS Homo sapiens
84 PTPN13 5783
Affinity Capture-MS Homo sapiens
85 NIN 51199
Proximity Label-MS Homo sapiens
86 GIGYF1  
Affinity Capture-MS Homo sapiens
87 CGN  
Affinity Capture-MS Homo sapiens
88 AMOT 154796
Proximity Label-MS Homo sapiens
89 RHOB 388
Proximity Label-MS Homo sapiens
90 KRAS 3845
Proximity Label-MS Homo sapiens
91 CTNNA1 1495
Proximity Label-MS Homo sapiens
92 STAMBPL1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
93 KLHL2 11275
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
94 TBC1D25  
Affinity Capture-MS Homo sapiens
95 ZRANB1 54764
Affinity Capture-MS Homo sapiens
96 DENND4C 55667
Affinity Capture-MS Homo sapiens
97 DEPDC1B 55789
Affinity Capture-MS Homo sapiens
98 NUDT21 11051
Co-fractionation Homo sapiens
99 PLEKHA4 57664
Affinity Capture-MS Homo sapiens
100 GIGYF2 26058
Affinity Capture-MS Homo sapiens
101 STARD13 90627
Affinity Capture-MS Homo sapiens
102 MAPKAP1 79109
Affinity Capture-MS Homo sapiens
103 FAM53C 51307
Affinity Capture-MS Homo sapiens
104 CWC27 10283
Co-fractionation Homo sapiens
105 RTKN 6242
Affinity Capture-MS Homo sapiens
106 DENND1A 57706
Affinity Capture-MS Homo sapiens
107 PPM1H  
Affinity Capture-MS Homo sapiens
108 MELK  
Affinity Capture-MS Homo sapiens
109 Myo1c 17913
Affinity Capture-MS Mus musculus
110 SRSF12  
Affinity Capture-MS Homo sapiens
111 SIPA1L3  
Affinity Capture-MS Homo sapiens
112 RPTOR 57521
Affinity Capture-MS Homo sapiens
113 SEPT10 151011
Proximity Label-MS Homo sapiens
114 KIF13B 23303
Affinity Capture-MS Homo sapiens
115 KCTD3  
Affinity Capture-MS Homo sapiens
116 CDC25C  
Affinity Capture-MS Homo sapiens
117 EDC3 80153
Affinity Capture-MS Homo sapiens
118 GAB2 9846
Affinity Capture-MS Homo sapiens
119 MKI67  
Affinity Capture-MS Homo sapiens
120 LATS1  
Proximity Label-MS Homo sapiens
121 MIF 4282
Affinity Capture-MS Homo sapiens
122 NF1 4763
Affinity Capture-MS Homo sapiens
123 TRIM37  
Proximity Label-MS Homo sapiens
124 DENND4A 10260
Affinity Capture-MS Homo sapiens
125 CEP135  
Proximity Label-MS Homo sapiens
126 PLEKHA7 144100
Affinity Capture-MS Homo sapiens
127 MYO6 4646
Proximity Label-MS Homo sapiens
128 KIF1C 10749
Affinity Capture-MS Homo sapiens
129 MAST3  
Affinity Capture-MS Homo sapiens
130 MAGI1  
Affinity Capture-MS Homo sapiens
131 SH3PXD2A 9644
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which SIPA1L1 is involved
PathwayEvidenceSource
Neurexins and neuroligins IEA Reactome
Neuronal System IEA Reactome
Protein-protein interactions at synapses IEA Reactome





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