ExoCarta: Gene summary

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Gene description for ISLR
Gene name	immunoglobulin superfamily containing leucine-rich repeat
Gene symbol	ISLR
Other names/aliases	HsT17563
Species	Homo sapiens
Database cross references - ISLR
ExoCarta	ExoCarta_3671
Vesiclepedia	VP_3671
Entrez Gene	3671
HGNC	6133
MIM	602059
UniProt	O14498
ISLR identified in sEVs derived from the following tissue/cell type
Chondrocytes	35931686
Chondrocytes	35931686

Gene ontology annotations for ISLR

Biological Process
	cell adhesion	GO:0007155	TAS
Subcellular Localization
	extracellular region	GO:0005576	TAS
	platelet alpha granule lumen	GO:0031093	TAS
	extracellular exosome	GO:0070062	HDA

Experiment description of studies that identified ISLR in sEVs

Experiment ID

494

MISEV standards
✔	Biophysical techniques
✔	Enriched markers
✘	Negative markers
✔	Particle analysis

Identified molecule

Protein

Identification method

Mass spectrometry

PubMed ID

35931686

Organism

Homo sapiens

Experiment description

Extracellular vesicles enriched in connexin 43 promote a senescent phenotype in bone and synovial cells contributing to osteoarthritis progression

Authors

"Varela-EirÃn M, Carpintero-FernÃ¡ndez P, GuitiÃ¡n-CaamaÃ±o A, Varela-VÃ¡zquez A, GarcÃa-Yuste A, SÃ¡nchez-Temprano A, Bravo-LÃ³pez SB, YaÃ±ez-Cabanas J, Fonseca E, Largo R, Mobasheri A, Caeiro JR, MayÃ¡n MD."

Journal name

Cell Death Dis

Publication year

2022

Sample

Chondrocytes

Sample name

Osteoarthritic cartilage

Isolation/purification methods

Differential centrifugation
Filtration
Ultracentrifugation

Flotation density

Molecules identified in the study

Protein

Methods used in the study

Western blotting
Mass spectometry

Experiment ID

496

MISEV standards
✘	Biophysical techniques
✔	Enriched markers
✘	Negative markers
✘	Particle analysis

Identified molecule

Protein

Identification method

Mass spectrometry

PubMed ID

35931686

Organism

Homo sapiens

Experiment description

Extracellular vesicles enriched in connexin 43 promote a senescent phenotype in bone and synovial cells contributing to osteoarthritis progression

Authors

Journal name

Cell Death Dis

Publication year

2022

Sample

Chondrocytes

Sample name

Healthy cartilage

Isolation/purification methods

Differential centrifugation
Filtration
Ultracentrifugation

Flotation density

Molecules identified in the study

Protein

Methods used in the study

Western blotting
Mass spectometry

Protein-protein interactions for ISLR

Protein Interactor

ExoCarta ID

Identification method

PubMed

Species

INTS4

Affinity Capture-MS

Homo sapiens

SLC25A13

10165

Affinity Capture-MS

Homo sapiens

DNAJC11

55735

Affinity Capture-MS

Homo sapiens

CACNA2D1

781

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

CNTNAP3

Affinity Capture-MS

Homo sapiens

ZRANB3

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

VAPA

9218

Affinity Capture-MS

Homo sapiens

CACNA2D2

9254

Affinity Capture-MS

Homo sapiens

IDUA

3425

Affinity Capture-MS

Homo sapiens

ACOT9

23597

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

TCTN3

Affinity Capture-MS

Homo sapiens

TUBB8

347688

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

SLC25A15

Affinity Capture-MS

Homo sapiens

SETX

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

PTP4A1

7803

Affinity Capture-MS

Homo sapiens

SLC27A6

Affinity Capture-MS

Homo sapiens

SPG7

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

MGAT5

4249

Affinity Capture-MS

Homo sapiens

TEX264

51368

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

ITGA7

3679

Affinity Capture-MS

Homo sapiens

B3GNT2

10678

Affinity Capture-MS

Homo sapiens

PLAU

5328

Affinity Capture-MS

Homo sapiens

LRRC1

55227

Affinity Capture-MS

Homo sapiens

MDN1

23195

Affinity Capture-MS

Homo sapiens

USP3

9960

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

TIMMDC1

Affinity Capture-MS

Homo sapiens

CD109

135228

Affinity Capture-MS

Homo sapiens

RFC3

5983

Affinity Capture-MS

Homo sapiens

SEL1L

6400

Affinity Capture-MS

Homo sapiens

CRELD2

79174

Affinity Capture-MS

Homo sapiens

OAF

220323

Affinity Capture-MS

Homo sapiens

STK11IP

114790

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

PSMC6

5706

Affinity Capture-MS

Homo sapiens

BCKDK

10295

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

SFXN2

Affinity Capture-MS

Homo sapiens

EDEM3

80267

Affinity Capture-MS

Homo sapiens

ERMP1

79956

Affinity Capture-MS

Homo sapiens

GUSB

2990

Affinity Capture-MS

Homo sapiens

RHOT1

55288

Affinity Capture-MS

Homo sapiens

IL17RA

23765

Affinity Capture-MS

Homo sapiens

ATP13A3

79572

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

PCYOX1

51449

Affinity Capture-MS

Homo sapiens

TMEM59

9528

Affinity Capture-MS

Homo sapiens

SLC25A33

Affinity Capture-MS

Homo sapiens

CHST12

55501

Affinity Capture-MS

Homo sapiens

ZNF562

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

DDX19B

11269

Affinity Capture-MS

Homo sapiens

POM121C

Affinity Capture-MS

Homo sapiens

GCNT1

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

LRIG2

Affinity Capture-MS

Homo sapiens

CLSTN1

22883

Affinity Capture-MS

Homo sapiens

SFXN3

81855

Affinity Capture-MS

Homo sapiens

HSP90B1

7184

Affinity Capture-MS

Homo sapiens

TUBA1A

7846

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

NTPCR

84284

Affinity Capture-MS

Homo sapiens

CHPF2

54480

Affinity Capture-MS

Homo sapiens

MANBA

4126

Affinity Capture-MS

Homo sapiens

SLC25A20

788

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

SYNJ2BP

55333

Affinity Capture-MS

Homo sapiens

GLB1L

79411

Affinity Capture-MS

Homo sapiens

NEK4

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

BMP7

655

Affinity Capture-MS

Homo sapiens

RDH11

51109

Affinity Capture-MS

Homo sapiens

PCSK9

255738

Affinity Capture-MS

Homo sapiens

CHCHD6

84303

Affinity Capture-MS

Homo sapiens

ART5

Affinity Capture-MS

Homo sapiens

GALNS

2588

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

TRMT2A

27037

Affinity Capture-MS

Homo sapiens

PGAP1

80055

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

AHCTF1

25909

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

EIF2B4

8890

Affinity Capture-MS

Homo sapiens

CERCAM

51148

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

SLC25A5

292

Affinity Capture-MS

Homo sapiens

SQRDL

58472

Affinity Capture-MS

Homo sapiens

MBTPS1

8720

Affinity Capture-MS

Homo sapiens

DDX11L8

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

HSPA5

3309

Affinity Capture-MS

Homo sapiens

SGPL1

8879

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

LPCAT4

Affinity Capture-MS

Homo sapiens

QSOX1

5768

Affinity Capture-MS

Homo sapiens

AGPAT1

10554

Affinity Capture-MS

Homo sapiens

TMEM39B

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

DHCR7

1717

Affinity Capture-MS

Homo sapiens

PON2

5445

Affinity Capture-MS

Homo sapiens

GNPTG

84572

Affinity Capture-MS

Homo sapiens

GALNT5

11227

Affinity Capture-MS

Homo sapiens

LRFN3

Affinity Capture-MS

Homo sapiens

CNPY3

10695

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

MYO19

Affinity Capture-MS

Homo sapiens

TUBA4A

7277

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

SEMA6B

10501

Affinity Capture-MS

Homo sapiens

GALNT18

Affinity Capture-MS

Homo sapiens

MTG1

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

CRLF1

9244

Affinity Capture-MS

Homo sapiens

MTOR

2475

Affinity Capture-MS

Homo sapiens

SLC38A10

124565

Affinity Capture-MS

Homo sapiens

CNPY4

245812

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

CTSF

8722

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

XRCC3

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

100

POGLUT1

56983

Affinity Capture-MS

Homo sapiens

101

LRRC40

55631

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

102

TTC13

Affinity Capture-MS

Homo sapiens

103

SLC25A16

Affinity Capture-MS

Homo sapiens

104

PLXNA3

55558

Affinity Capture-MS

Homo sapiens

105

SLC25A6

293

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

106

RHOBTB3

22836

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

107

METRN

79006

Affinity Capture-MS

Homo sapiens

108

LARS2

23395

Affinity Capture-MS

Homo sapiens

109

PLXNA1

5361

Affinity Capture-MS

Homo sapiens

110

SLC25A40

Affinity Capture-MS

Homo sapiens

111

CELSR1

9620

Affinity Capture-MS

Homo sapiens

112

TUBB3

10381

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

113

SIL1

64374

Affinity Capture-MS

Homo sapiens

114

PPOX

5498

Affinity Capture-MS

Homo sapiens

115

CDC6

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

116

GPD1L

23171

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

117

OS9

10956

Affinity Capture-MS

Homo sapiens

118

SLC10A7

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

119

TUBB4A

10382

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

120

SFXN1

94081

Affinity Capture-MS

Homo sapiens

121

SEMA3B

7869

Affinity Capture-MS

Homo sapiens

122

LPCAT2

54947

Affinity Capture-MS

Homo sapiens

123

SLC25A4

291

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

124

RPL23

9349

Affinity Capture-MS

Homo sapiens

125

LAMB2

3913

Affinity Capture-MS

Homo sapiens

126

GPC3

2719

Affinity Capture-MS

Homo sapiens

127

OLFM2

Affinity Capture-MS

Homo sapiens

128

LAMA5

3911

Affinity Capture-MS

Homo sapiens

129

LMLN

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

130

CLPTM1L

81037

Affinity Capture-MS

Homo sapiens

131

TAP1

6890

Affinity Capture-MS

Homo sapiens

132

ARSK

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

133

CILP2

Affinity Capture-MS

Homo sapiens

134

CHSY3

337876

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

135

RTEL1

51750

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

136

CNTNAP3B

Affinity Capture-MS

Homo sapiens

View the network

Pathways in which ISLR is involved

Pathway	Evidence	Source
Hemostasis	TAS	Reactome
Platelet activation, signaling and aggregation	TAS	Reactome
Platelet degranulation	TAS	Reactome
Response to elevated platelet cytosolic Ca2+	TAS	Reactome

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