Gene description for MCL1
Gene name	myeloid cell leukemia 1
Gene symbol	MCL1
Other names/aliases	BCL2L3 EAT MCL1-ES MCL1L MCL1S Mcl-1 TM bcl2-L-3 mcl1/EAT
Species	Homo sapiens
Database cross references - MCL1
ExoCarta	ExoCarta_4170
Vesiclepedia	VP_4170
Entrez Gene	4170
HGNC	6943
MIM	159552
UniProt	Q07820
MCL1 identified in sEVs derived from the following tissue/cell type
Endothelial cells	26027894

Gene ontology annotations for MCL1

Molecular Function     protein binding GO:0005515 IPI     protein transmembrane transporter activity GO:0008320 TAS     channel activity GO:0015267 IBA     protein heterodimerization activity GO:0046982 IPI     BH3 domain binding GO:0051434 IPI Biological Process     cell fate determination GO:0001709 NAS     release of cytochrome c from mitochondria GO:0001836 IBA     DNA damage response GO:0006974 IMP     mitochondrial fusion GO:0008053 IBA     intrinsic apoptotic signaling pathway in response to DNA damage GO:0008630 IBA     negative regulation of autophagy GO:0010507 IMP     cellular homeostasis GO:0019725 NAS     response to cytokine GO:0034097 IDA     regulation of apoptotic process GO:0042981 IDA     positive regulation of apoptotic process GO:0043065 IDA     negative regulation of apoptotic process GO:0043066 IDA     positive regulation of neuron apoptotic process GO:0043525 IBA     protein transmembrane transport GO:0071806 IEA     extrinsic apoptotic signaling pathway in absence of ligand GO:0097192 IBA     extrinsic apoptotic signaling pathway in absence of ligand GO:0097192 IMP     positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway GO:1903378 IGI     negative regulation of anoikis GO:2000811 IMP     negative regulation of extrinsic apoptotic signaling pathway in absence of ligand GO:2001240 IMP Subcellular Localization     nucleus GO:0005634 IDA     nucleoplasm GO:0005654 IEA     cytoplasm GO:0005737 TAS     mitochondrion GO:0005739 HTP     mitochondrion GO:0005739 IDA     mitochondrial outer membrane GO:0005741 IBA     mitochondrial outer membrane GO:0005741 TAS     cytosol GO:0005829 ISS     cytosol GO:0005829 TAS     membrane GO:0016020 IDA     membrane GO:0016020 ISS     Bcl-2 family protein complex GO:0097136 IDA     Bcl-2 family protein complex GO:0097136 IPI