Gene description for NBL1
Gene name neuroblastoma 1, DAN family BMP antagonist
Gene symbol NBL1
Other names/aliases D1S1733E
DAN
DAND1
NB
NO3
Species Homo sapiens
 Database cross references - NBL1
ExoCarta ExoCarta_4681
Vesiclepedia VP_4681
Entrez Gene 4681
HGNC 7650
MIM 600613
UniProt P41271  
 NBL1 identified in sEVs derived from the following tissue/cell type
Mesenchymal stem cells Unpublished / Not applicable
 Gene ontology annotations for NBL1
Molecular Function
    protein binding GO:0005515 IPI
    morphogen activity GO:0016015 ISS
    BMP binding GO:0036122 IBA
    BMP binding GO:0036122 ISS
    identical protein binding GO:0042802 IMP
    receptor ligand activity GO:0048018 IBA
Biological Process
    signal transduction GO:0007165 IEA
    nervous system development GO:0007399 ISS
    negative regulation of BMP signaling pathway GO:0030514 IDA
    negative regulation of BMP signaling pathway GO:0030514 IMP
    sequestering of BMP in extracellular matrix GO:0035582 ISS
    sequestering of BMP from receptor via BMP binding GO:0038098 IBA
    sequestering of BMP from receptor via BMP binding GO:0038098 IDA
    positive regulation of neuron differentiation GO:0045666 ISS
    determination of dorsal identity GO:0048263 ISS
    neuron projection morphogenesis GO:0048812 ISS
    negative regulation of monocyte chemotaxis GO:0090027 ISS
Subcellular Localization
    extracellular space GO:0005615 IBA
    extracellular space GO:0005615 IC
    extracellular space GO:0005615 IDA
 Experiment description of studies that identified NBL1 in sEVs
1
Experiment ID 126
MISEV standards
✘ Biophysical techniques
✔
GAPDH
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Antibody array
PubMed ID Unpublished / Not applicable
Organism Homo sapiens
Experiment description Mesenchymal Stem Cell Exosomes: The Future MSC-based Therapy?
Authors "Ruenn Chai Lai, Ronne Wee Yeh Yeo, Soon Sim Tan, Bin Zhang, Yijun Yin, Newman Siu Kwan Sze, Andre Choo, and Sai Kiang Lim"
Journal name Mesenchymal Stem Cell Therapy
Publication year 2011
Sample Mesenchymal stem cells
Sample name huES9.E1
Isolation/purification methods HPLC
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Antobody array
Mass spectrometry
 Protein-protein interactions for NBL1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 NCALD 83988
Two-hybrid Homo sapiens
2 HPCAL1 3241
Two-hybrid Homo sapiens
3 MEOX2  
Two-hybrid Homo sapiens
4 NCS1 23413
Two-hybrid Homo sapiens
5 BAG6 7917
Two-hybrid Homo sapiens
6 LOC100131303  
Two-hybrid Homo sapiens
7 HNRNPH1 3187
Affinity Capture-RNA Homo sapiens
8 MRPL12 6182
Two-hybrid Homo sapiens
9 ZMIZ2  
Two-hybrid Homo sapiens
10 PLA2G2F  
Two-hybrid Homo sapiens
11 KRTAP11-1  
Two-hybrid Homo sapiens
12 UBQLN1 29979
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
13 LRIG1 26018
Two-hybrid Homo sapiens
14 SLPI 6590
Two-hybrid Homo sapiens
15 UBQLN2 29978
Two-hybrid Homo sapiens
View the network image/svg+xml
 Pathways in which NBL1 is involved
No pathways found





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