Gene description for SLPI
Gene name secretory leukocyte peptidase inhibitor
Gene symbol SLPI
Other names/aliases ALK1
ALP
BLPI
HUSI
HUSI-I
MPI
WAP4
WFDC4
Species Homo sapiens
 Database cross references - SLPI
ExoCarta ExoCarta_6590
Vesiclepedia VP_6590
Entrez Gene 6590
HGNC 11092
MIM 107285
UniProt P03973  
 SLPI identified in sEVs derived from the following tissue/cell type
Saliva 19199708    
 Gene ontology annotations for SLPI
Molecular Function
    DNA binding GO:0003677 IDA
    mRNA binding GO:0003729 IDA
    endopeptidase inhibitor activity GO:0004866 IDA
    serine-type endopeptidase inhibitor activity GO:0004867 IBA
    serine-type endopeptidase inhibitor activity GO:0004867 IDA
    protein binding GO:0005515 IPI
    enzyme binding GO:0019899 IPI
Biological Process
    immune response GO:0006955 ISS
    antibacterial humoral response GO:0019731 IBA
    antibacterial humoral response GO:0019731 IDA
    antibacterial humoral response GO:0019731 ISS
    negative regulation of protein binding GO:0032091 IDA
    response to lipopolysaccharide GO:0032496 ISS
    modulation of process of another organism GO:0035821 IDA
    negative regulation of viral genome replication GO:0045071 IDA
    innate immune response GO:0045087 IBA
    innate immune response GO:0045087 ISS
Subcellular Localization
    extracellular region GO:0005576 TAS
    extracellular space GO:0005615 IBA
    extracellular space GO:0005615 IDA
    Golgi apparatus GO:0005794 IDA
    specific granule lumen GO:0035580 TAS
    collagen-containing extracellular matrix GO:0062023 HDA
    collagen-containing extracellular matrix GO:0062023 HDA
    extracellular exosome GO:0070062 HDA
 Experiment description of studies that identified SLPI in sEVs
1
Experiment ID 66
MISEV standards
IEM
Biophysical techniques
TSG101|Alix|CD63|CD81
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19199708    
Organism Homo sapiens
Experiment description Proteomic analysis of human parotid gland exosomes by multidimensional protein identification technology (MudPIT).
Authors "Gonzalez-Begne M, Lu B, Han X, Hagen FK, Hand AR, Melvin JE, Yates JR"
Journal name JPR
Publication year 2009
Sample Saliva
Sample name Saliva
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [LTQ]
Western blotting
Immunoelectron Microscopy
 Protein-protein interactions for SLPI
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 MINOS1-NBL1  
Two-hybrid Homo sapiens
2 LAT 27040
Two-hybrid Homo sapiens
3 GRN 2896
Affinity Capture-Western Homo sapiens
4 NBL1 4681
Two-hybrid Homo sapiens
5 UBQLN2 29978
Two-hybrid Homo sapiens
6 FAM9B  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
7 BCAR1 9564
Co-fractionation Homo sapiens
8 PIH1D2  
Two-hybrid Homo sapiens
9 NAA16 79612
Co-fractionation Homo sapiens
10 PLSCR1 5359
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
11 HOXA1 3198
Two-hybrid Homo sapiens
12 MMP14 4323
Biochemical Activity Homo sapiens
13 SGTB  
Two-hybrid Homo sapiens
14 WDYHV1  
Two-hybrid Homo sapiens
15 CIB3  
Two-hybrid Homo sapiens
16 TRIM11  
Affinity Capture-MS Homo sapiens
17 SMIM14  
Two-hybrid Homo sapiens
18 CALN1  
Two-hybrid Homo sapiens
19 SGTA 6449
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
20 MKRN3  
Two-hybrid Homo sapiens
21 UBQLN1 29979
Two-hybrid Homo sapiens
22 EFEMP1 2202
Two-hybrid Homo sapiens
View the network image/svg+xml
 Pathways in which SLPI is involved
PathwayEvidenceSource
Immune System TAS Reactome
Innate Immune System TAS Reactome
Neutrophil degranulation TAS Reactome





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