Gene description for LACTB2
Gene name lactamase, beta 2
Gene symbol LACTB2
Other names/aliases CGI-83
Species Homo sapiens
 Database cross references - LACTB2
ExoCarta ExoCarta_51110
Vesiclepedia VP_51110
Entrez Gene 51110
HGNC 18512
UniProt Q53H82  
 LACTB2 identified in sEVs derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Retinal pigment epithelial cells 35333565    
Retinal pigment epithelial cells 35333565    
 Gene ontology annotations for LACTB2
Molecular Function
    single-stranded RNA binding GO:0003727 IBA
    single-stranded RNA binding GO:0003727 IDA
    RNA endonuclease activity GO:0004521 IBA
    RNA endonuclease activity GO:0004521 IDA
    protein binding GO:0005515 IPI
    zinc ion binding GO:0008270 IDA
Subcellular Localization
    mitochondrion GO:0005739 HTP
    mitochondrial matrix GO:0005759 IBA
    mitochondrial matrix GO:0005759 IDA
 Experiment description of studies that identified LACTB2 in sEVs
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
5
Experiment ID 834
MISEV standards
✔
EM
Biophysical techniques
✔
LAMP2|CD63|FLOT1|ITGA2B|ICAM1|CD9|CD151|TFRC|RAB5A|GAPDH|AQP1|TSG101
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35333565    
Organism Homo sapiens
Experiment description LAMP2A regulates the loading of proteins into exosomes
Authors "Ferreira JV, da Rosa Soares A, Ramalho J, Máximo Carvalho C, Cardoso MH, Pintado P, Carvalho AS, Beck HC, Matthiesen R, Zuzarte M, Girão H, van Niel G, Pereira P"
Journal name Sci Adv
Publication year 2022
Sample Retinal pigment epithelial cells
Sample name ARPE-19
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
6
Experiment ID 835
MISEV standards
✔
EM
Biophysical techniques
✔
CD63|FLOT1|ITGA2B|ICAM1|CD9|CD151|TFRC|RAB5A|GAPDH|AQP1|TSG101
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35333565    
Organism Homo sapiens
Experiment description LAMP2A regulates the loading of proteins into exosomes
Authors "Ferreira JV, da Rosa Soares A, Ramalho J, Máximo Carvalho C, Cardoso MH, Pintado P, Carvalho AS, Beck HC, Matthiesen R, Zuzarte M, Girão H, van Niel G, Pereira P"
Journal name Sci Adv
Publication year 2022
Sample Retinal pigment epithelial cells
Sample name ARPE-19
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for LACTB2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 SIAH1  
Two-hybrid Homo sapiens
2 MPST 4357
Co-fractionation Homo sapiens
3 GSTP1 2950
Co-fractionation Homo sapiens
4 NDUFAB1 4706
Co-fractionation Homo sapiens
5 NAGK 55577
Two-hybrid Homo sapiens
6 DDAH2 23564
Co-fractionation Homo sapiens
7 C1orf198 84886
Co-fractionation Homo sapiens
8 PALM2  
Co-fractionation Homo sapiens
9 PMPCA 23203
Co-fractionation Homo sapiens
10 SCRN1 9805
Affinity Capture-MS Homo sapiens
11 MTPN 136319
Co-fractionation Homo sapiens
12 AK2 204
Co-fractionation Homo sapiens
13 GLRX5 51218
Co-fractionation Homo sapiens
14 SOD1 6647
Co-fractionation Homo sapiens
15 CKM  
Affinity Capture-MS Homo sapiens
16 GUK1 2987
Co-fractionation Homo sapiens
17 DDAH1 23576
Co-fractionation Homo sapiens
18 SMEK2  
Co-fractionation Homo sapiens
19 MGEA5 10724
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
20 WDR1 9948
Co-fractionation Homo sapiens
21 SSU72 29101
Co-fractionation Homo sapiens
22 PDCD6IP 10015
Co-fractionation Homo sapiens
23 ISCA2 122961
Co-fractionation Homo sapiens
24 LAP3 51056
Co-fractionation Homo sapiens
25 UCHL1 7345
Co-fractionation Homo sapiens
26 CMPK1 51727
Co-fractionation Homo sapiens
27 TXNL1 9352
Co-fractionation Homo sapiens
28 UBE2H 7328
Co-fractionation Homo sapiens
29 NENF 29937
Co-fractionation Homo sapiens
30 NUDT19 390916
Co-fractionation Homo sapiens
31 NDRG3 57446
Co-fractionation Homo sapiens
32 PARK7 11315
Co-fractionation Homo sapiens
33 C21orf33  
Co-fractionation Homo sapiens
34 HDHD3 81932
Co-fractionation Homo sapiens
35 COA7  
Co-fractionation Homo sapiens
36 MYH13 8735
Affinity Capture-MS Homo sapiens
37 MYH1  
Affinity Capture-MS Homo sapiens
38 GRHPR 9380
Co-fractionation Homo sapiens
39 ACTN3 89
Affinity Capture-MS Homo sapiens
40 CRYZ 1429
Co-fractionation Homo sapiens
41 ABHD11 83451
Co-fractionation Homo sapiens
42 VCP 7415
Affinity Capture-MS Homo sapiens
43 PRDX6 9588
Co-fractionation Homo sapiens
44 SPR 6697
Co-fractionation Homo sapiens
45 MIPEP  
Co-fractionation Homo sapiens
46 DGUOK  
Co-fractionation Homo sapiens
47 LYPLA2 11313
Co-fractionation Homo sapiens
48 MYH7 4625
Affinity Capture-MS Homo sapiens
49 PGM3 5238
Co-fractionation Homo sapiens
50 HINT2 84681
Co-fractionation Homo sapiens
51 ENO1 2023
Co-fractionation Homo sapiens
52 NUP210 23225
Co-fractionation Homo sapiens
53 CTSB 1508
Co-fractionation Homo sapiens
54 ISOC1 51015
Co-fractionation Homo sapiens
55 SMS 6611
Co-fractionation Homo sapiens
56 TBCA 6902
Co-fractionation Homo sapiens
57 HAGH 3029
Co-fractionation Homo sapiens
58 RAB11FIP5 26056
Co-fractionation Homo sapiens
59 FXN  
Co-fractionation Homo sapiens
60 MDH1 4190
Co-fractionation Homo sapiens
61 PDP1 54704
Co-fractionation Homo sapiens
62 HINT1 3094
Co-fractionation Homo sapiens
63 CLIC4 25932
Co-fractionation Homo sapiens
64 COIL  
Co-fractionation Homo sapiens
65 MYH4  
Affinity Capture-MS Homo sapiens
66 GPI 2821
Co-fractionation Homo sapiens
67 COX4I1 1327
Co-fractionation Homo sapiens
View the network image/svg+xml
 Pathways in which LACTB2 is involved
No pathways found





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