Experiment description of studies that identified NOP16 in sEVs

1 Experiment ID 207 MISEV standards ✔ EM Biophysical techniques ✔ TSG101|HSP70|FLOT1 Enriched markers ✔ VDAC Negative markers ✔ NTA Particle analysis Identified molecule protein Identification method Mass spectrometry PubMed ID 23161513     Organism Homo sapiens Experiment description Proteomic analysis of exosomes from mutant KRAS colon cancer cells identifies intercellular transfer of mutant KRAS. Authors "Demory Beckler M, Higginbotham JN, Franklin JL, Ham AJ, Halvey PJ, Imasuen IE, Whitwell C, Li M, Liebler DC, Coffey RJ." Journal name Mol Cell Proteomics Publication year 2012 Sample Colorectal cancer cells Sample name DKO-1 Isolation/purification methods Differential centrifugation Filtration Flotation density - Molecules identified in the study Protein Methods used in the study Mass spectrometry

2 Experiment ID 208 MISEV standards ✔ EM Biophysical techniques ✔ TSG101|HSP70|FLOT1 Enriched markers ✔ VDAC Negative markers ✔ NTA Particle analysis Identified molecule protein Identification method Mass spectrometry PubMed ID 23161513     Organism Homo sapiens Experiment description Proteomic analysis of exosomes from mutant KRAS colon cancer cells identifies intercellular transfer of mutant KRAS. Authors "Demory Beckler M, Higginbotham JN, Franklin JL, Ham AJ, Halvey PJ, Imasuen IE, Whitwell C, Li M, Liebler DC, Coffey RJ." Journal name Mol Cell Proteomics Publication year 2012 Sample Colorectal cancer cells Sample name Dks-8 Isolation/purification methods Differential centrifugation Filtration Flotation density - Molecules identified in the study Protein Methods used in the study Mass spectrometry

3 Experiment ID 209 MISEV standards ✘ Biophysical techniques ✔ TSG101|HSP70|FLOT1 Enriched markers ✔ VDAC Negative markers ✔ NTA Particle analysis Identified molecule protein Identification method Mass spectrometry PubMed ID 23161513     Organism Homo sapiens Experiment description Proteomic analysis of exosomes from mutant KRAS colon cancer cells identifies intercellular transfer of mutant KRAS. Authors "Demory Beckler M, Higginbotham JN, Franklin JL, Ham AJ, Halvey PJ, Imasuen IE, Whitwell C, Li M, Liebler DC, Coffey RJ." Journal name Mol Cell Proteomics Publication year 2012 Sample Colorectal cancer cells Sample name DLD-1 Isolation/purification methods Differential centrifugation Filtration Flotation density - Molecules identified in the study Protein Methods used in the study Mass spectrometry

Protein-protein interactions for NOP16

Protein Interactor ExoCarta ID Identification method PubMed Species 1 FAN1   Affinity Capture-MS Homo sapiens 2 RPSA 3921 Affinity Capture-MS Homo sapiens 3 CDC14B 8555 Affinity Capture-MS Homo sapiens 4 SRP19 6728 Affinity Capture-MS Homo sapiens 5 ZNF668   Affinity Capture-MS Homo sapiens 6 RPSAP58 388524 Affinity Capture-MS Homo sapiens 7 H1FNT   Affinity Capture-MS Homo sapiens 8 CLEC3A   Affinity Capture-MS Homo sapiens 9 ZNF346   Affinity Capture-MS Homo sapiens 10 KLF9 687 Proximity Label-MS Homo sapiens 11 SRPK2 6733 Biochemical Activity Homo sapiens 12 MRPS27 23107 Affinity Capture-MS Homo sapiens 13 TARDBP 23435 Affinity Capture-MS Homo sapiens 14 HIST1H1D 3007 Affinity Capture-MS Homo sapiens 15 LHX2   Proximity Label-MS Homo sapiens 16 E2F1 1869 Proximity Label-MS Homo sapiens 17 TLX3   Proximity Label-MS Homo sapiens 18 NOP56 10528 Affinity Capture-MS Homo sapiens 19 RPS19 6223 Affinity Capture-MS Homo sapiens 20 RPL10 6134 Affinity Capture-MS Homo sapiens 21 RPL14 9045 Affinity Capture-MS Homo sapiens 22 PNMAL1   Affinity Capture-MS Homo sapiens 23 CAND1 55832 Affinity Capture-MS Homo sapiens 24 SOX2   Affinity Capture-MS Homo sapiens 25 APP 351 Reconstituted Complex Homo sapiens Reconstituted Complex Homo sapiens 26 USP36   Affinity Capture-MS Homo sapiens 27 WDR48 57599 Affinity Capture-MS Homo sapiens 28 PRR11   Affinity Capture-MS Homo sapiens 29 KIF23 9493 Affinity Capture-MS Homo sapiens 30 NOLC1 9221 Co-fractionation Homo sapiens 31 SH3BP1 23616 Affinity Capture-MS Homo sapiens 32 COPS5 10987 Affinity Capture-MS Homo sapiens 33 FBXW7   Affinity Capture-MS Homo sapiens 34 PRC1 9055 Affinity Capture-MS Homo sapiens 35 BHLHA15   Affinity Capture-MS Homo sapiens Affinity Capture-MS Homo sapiens 36 NPM1 4869 Affinity Capture-MS Homo sapiens Affinity Capture-MS Homo sapiens Affinity Capture-MS Homo sapiens 37 KLF6   Proximity Label-MS Homo sapiens 38 KLF15   Proximity Label-MS Homo sapiens Affinity Capture-MS Homo sapiens 39 RPS9 6203 Affinity Capture-MS Homo sapiens 40 ADARB1 104 Affinity Capture-MS Homo sapiens 41 PRKRA 8575 Affinity Capture-MS Homo sapiens Affinity Capture-MS Homo sapiens 42 SRP68 6730 Affinity Capture-MS Homo sapiens 43 MRPS7 51081 Affinity Capture-MS Homo sapiens 44 MECP2 4204 Affinity Capture-MS Homo sapiens 45 MYCN   Affinity Capture-MS Homo sapiens 46 RBM42   Affinity Capture-MS Homo sapiens 47 ADARB2   Affinity Capture-MS Homo sapiens 48 NCSTN 23385 Co-fractionation Homo sapiens 49 RPL19 6143 Affinity Capture-MS Homo sapiens 50 RBM8A 9939 Affinity Capture-MS Homo sapiens 51 KIF14 9928 Affinity Capture-MS Homo sapiens 52 KLF16   Proximity Label-MS Homo sapiens Affinity Capture-MS Homo sapiens 53 HIST1H4A 8359 Affinity Capture-MS Homo sapiens 54 THAP3   Affinity Capture-MS Homo sapiens 55 RPL4 6124 Affinity Capture-MS Homo sapiens 56 RPS10 6204 Affinity Capture-MS Homo sapiens 57 RBM4B   Affinity Capture-MS Homo sapiens Affinity Capture-MS Homo sapiens 58 SRSF6 6431 Affinity Capture-MS Homo sapiens Affinity Capture-MS Homo sapiens 59 PURG   Affinity Capture-MS Homo sapiens 60 RPL5 6125 Affinity Capture-MS Homo sapiens 61 HIST1H2AM 8336 Affinity Capture-MS Homo sapiens 62 SRSF4 6429 Affinity Capture-MS Homo sapiens 63 LHX1   Proximity Label-MS Homo sapiens 64 RPL18A 6142 Affinity Capture-MS Homo sapiens 65 Srp72   Affinity Capture-MS Mus musculus 66 RPL31 6160 Affinity Capture-MS Homo sapiens 67 IFI16 3428 Affinity Capture-MS Homo sapiens 68 HIST1H1E 3008 Affinity Capture-MS Homo sapiens 69 HIST1H1C 3006 Cross-Linking-MS (XL-MS) Homo sapiens 70 DDX54 79039 Affinity Capture-MS Homo sapiens 71 LYAR 55646 Affinity Capture-MS Homo sapiens 72 RPLP0 6175 Affinity Capture-MS Homo sapiens 73 MAGEB2 4113 Affinity Capture-MS Homo sapiens 74 MYBBP1A 10514 Co-fractionation Homo sapiens Affinity Capture-MS Homo sapiens 75 KLF12   Proximity Label-MS Homo sapiens 76 SRPK1 6732 Biochemical Activity Homo sapiens 77 NFATC4 4776 Proximity Label-MS Homo sapiens 78 SP100 6672 Affinity Capture-MS Homo sapiens 79 RPL11 6135 Affinity Capture-MS Homo sapiens 80 RSL1D1 26156 Affinity Capture-MS Homo sapiens 81 FGFBP1 9982 Affinity Capture-MS Homo sapiens 82 STK3 6788 Affinity Capture-MS Homo sapiens 83 EPB41L1 2036 Co-fractionation Homo sapiens 84 IPO5 3843 Affinity Capture-MS Homo sapiens Affinity Capture-MS Homo sapiens 85 THUMPD1 55623 Affinity Capture-MS Homo sapiens 86 CIAO1 9391 Affinity Capture-MS Homo sapiens 87 RC3H2   Affinity Capture-MS Homo sapiens 88 RPL35 11224 Affinity Capture-MS Homo sapiens 89 SRSF1 6426 Affinity Capture-MS Homo sapiens 90 NPM3 10360 Affinity Capture-MS Homo sapiens 91 RPS6 6194 Proximity Label-MS Homo sapiens 92 SRSF5 6430 Affinity Capture-MS Homo sapiens 93 RPL3 6122 Affinity Capture-MS Homo sapiens 94 NAP1L1 4673 Affinity Capture-MS Homo sapiens Affinity Capture-MS Homo sapiens Affinity Capture-MS Homo sapiens Affinity Capture-MS Homo sapiens 95 RPL7L1 285855 Affinity Capture-MS Homo sapiens 96 PCBP1 5093 Affinity Capture-MS Homo sapiens 97 MYC   Proximity Label-MS Homo sapiens Affinity Capture-MS Homo sapiens 98 OASL 8638 Affinity Capture-MS Homo sapiens 99 SET 6418 Affinity Capture-MS Homo sapiens 100 NHP2L1 4809 Co-fractionation Homo sapiens 101 HP1BP3 50809 Co-fractionation Homo sapiens 102 HIST1H1A 3024 Affinity Capture-MS Homo sapiens 103 DDRGK1 65992 Affinity Capture-MS Homo sapiens 104 ZC3HAV1 56829 Affinity Capture-MS Homo sapiens Affinity Capture-MS Homo sapiens 105 MYB   Proximity Label-MS Homo sapiens 106 RPL26 6154 Affinity Capture-MS Homo sapiens 107 ZC3H3   Affinity Capture-MS Homo sapiens Affinity Capture-MS Homo sapiens 108 MRPL18 29074 Affinity Capture-MS Homo sapiens 109 RPL13 6137 Affinity Capture-MS Homo sapiens 110 RIT1 6016 Negative Genetic Homo sapiens 111 RNF151   Affinity Capture-MS Homo sapiens 112 FBXL6   Affinity Capture-MS Homo sapiens 113 MNDA 4332 Affinity Capture-MS Homo sapiens 114 DGCR8   Affinity Capture-MS Homo sapiens 115 SRP72 6731 Affinity Capture-MS Homo sapiens 116 H2AFB3   Affinity Capture-MS Homo sapiens 117 NIFK 84365 Affinity Capture-MS Homo sapiens 118 APOBEC3D   Affinity Capture-MS Homo sapiens 119 KLF8   Proximity Label-MS Homo sapiens 120 DRG1 4733 Affinity Capture-MS Homo sapiens 121 KLF5   Proximity Label-MS Homo sapiens 122 KRR1 11103 Affinity Capture-MS Homo sapiens Affinity Capture-MS Homo sapiens 123 NEIL1   Affinity Capture-MS Homo sapiens 124 RPL7A 6130 Affinity Capture-MS Homo sapiens 125 RPS8 6202 Affinity Capture-MS Homo sapiens 126 SOS2 6655 Affinity Capture-MS Homo sapiens 127 RPL23A 6147 Affinity Capture-MS Homo sapiens Affinity Capture-MS Homo sapiens 128 KRAS 3845 Synthetic Lethality Homo sapiens Negative Genetic Homo sapiens 129 GNB2L1 10399 Affinity Capture-MS Homo sapiens 130 RC3H1 149041 Affinity Capture-MS Homo sapiens 131 REPIN1   Affinity Capture-MS Homo sapiens 132 HIST1H2AE 3012 Affinity Capture-MS Homo sapiens 133 RPL17 6139 Affinity Capture-MS Homo sapiens 134 NAP1L5   Affinity Capture-MS Homo sapiens 135 HERC5 51191 Affinity Capture-MS Homo sapiens Affinity Capture-MS Homo sapiens 136 NHLH1   Proximity Label-MS Homo sapiens View the network

Pathways in which NOP16 is involved

No pathways found