ExoCarta: Gene summary

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Gene description for RPL7L1
Gene name	ribosomal protein L7-like 1
Gene symbol	RPL7L1
Other names/aliases	dJ475N16.4
Species	Homo sapiens
Database cross references - RPL7L1
ExoCarta	ExoCarta_285855
Vesiclepedia	VP_285855
Entrez Gene	285855
HGNC	21370
UniProt	Q6DKI1
RPL7L1 identified in sEVs derived from the following tissue/cell type
Bone marrow mesenchymal stem cells	36408942
Bone marrow mesenchymal stem cells	36408942
Bone marrow mesenchymal stem cells	36408942
Bone marrow mesenchymal stem cells	36408942

Gene ontology annotations for RPL7L1

Molecular Function
	RNA binding	GO:0003723	HDA
	RNA binding	GO:0003723	IBA
	structural constituent of ribosome	GO:0003735	IBA
	protein binding	GO:0005515	IPI
Biological Process
	maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	GO:0000463	IBA
	blastocyst formation	GO:0001825	IEA
Subcellular Localization
	nucleolus	GO:0005730	IEA
	mitochondrion	GO:0005739	HTP
	cytosolic large ribosomal subunit	GO:0022625	IBA

Experiment description of studies that identified RPL7L1 in sEVs

Experiment ID

489

MISEV standards
✔ EM	Biophysical techniques
✔ Cd9\|Cd81\|Cd63\|Gapdh\|Sdcbp\|Lamp1\|Aqp1\|Rab5a\|Icam1\|Cd82\|Itga2b\|Tsg101\|Lamp2\|Rab35\|Flot1\|Flot2\|Cd151\|Rab5b\|Tfrc\|Uchl1	Enriched markers
✔ Canx	Negative markers
✔ NTA	Particle analysis

Identified molecule

Protein

Identification method

Mass spectrometry

PubMed ID

36408942

Organism

Rattus norvegicus

Experiment description

Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells

Authors

"Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."

Journal name

Proteomics

Publication year

2023

Sample

Bone marrow mesenchymal stem cells

Sample name

BMSC - Passage 6

Isolation/purification methods

Differential centrifugation
Filtration
Ultracentrifugation

Flotation density

Molecules identified in the study

Protein

Methods used in the study

Western blotting
Mass spectometry

Experiment ID

490

MISEV standards
✔ EM	Biophysical techniques
✔ Cd9\|Cd81\|Cd63\|Gapdh\|Sdcbp\|Lamp1\|Aqp1\|Rab5a\|Icam1\|Cd82\|Itga2b\|Tsg101\|Lamp2\|Rab35\|Flot1\|Flot2\|Cd151\|Rab5b\|Tfrc\|Uchl1	Enriched markers
✔ Canx	Negative markers
✔ NTA	Particle analysis

Identified molecule

Protein

Identification method

Mass spectrometry

PubMed ID

36408942

Organism

Rattus norvegicus

Experiment description

Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells

Authors

"Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."

Journal name

Proteomics

Publication year

2023

Sample

Bone marrow mesenchymal stem cells

Sample name

BMSC - Passage 7

Isolation/purification methods

Differential centrifugation
Filtration
Ultracentrifugation

Flotation density

Molecules identified in the study

Protein

Methods used in the study

Western blotting
Mass spectometry

Experiment ID

491

MISEV standards
✔ EM	Biophysical techniques
✔ Cd9\|Cd81\|Cd63\|Gapdh\|Sdcbp\|Lamp1\|Aqp1\|Rab5a\|Icam1\|Cd82\|Itga2b\|Tsg101\|Lamp2\|Rab35\|Flot1\|Flot2\|Cd151\|Rab5b\|Tfrc\|Uchl1	Enriched markers
✔ Canx	Negative markers
✔ NTA	Particle analysis

Identified molecule

Protein

Identification method

Mass spectrometry

PubMed ID

36408942

Organism

Rattus norvegicus

Experiment description

Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells

Authors

"Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."

Journal name

Proteomics

Publication year

2023

Sample

Bone marrow mesenchymal stem cells

Sample name

BMSC - Passage 8

Isolation/purification methods

Differential centrifugation
Filtration
Ultracentrifugation

Flotation density

Molecules identified in the study

Protein

Methods used in the study

Western blotting
Mass spectometry

Experiment ID

492

MISEV standards
✔ EM	Biophysical techniques
✔ Cd9\|Cd81\|Cd63\|Gapdh\|Sdcbp\|Lamp1\|Aqp1\|Rab5a\|Icam1\|Cd82\|Itga2b\|Tsg101\|Lamp2\|Rab35\|Flot1\|Flot2\|Cd151\|Rab5b\|Tfrc\|Uchl1	Enriched markers
✔ Canx	Negative markers
✔ NTA	Particle analysis

Identified molecule

Protein

Identification method

Mass spectrometry

PubMed ID

36408942

Organism

Rattus norvegicus

Experiment description

Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells

Authors

"Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."

Journal name

Proteomics

Publication year

2023

Sample

Bone marrow mesenchymal stem cells

Sample name

BMSC - Passage 9

Isolation/purification methods

Differential centrifugation
Filtration
Ultracentrifugation

Flotation density

Molecules identified in the study

Protein

Methods used in the study

Western blotting
Mass spectometry

Protein-protein interactions for RPL7L1

Protein Interactor

ExoCarta ID

Identification method

PubMed

Species

UBE2H

7328

Affinity Capture-MS

Homo sapiens

RIT1

6016

Negative Genetic

Homo sapiens

RPSA

3921

Affinity Capture-MS

Homo sapiens

RPL26L1

51121

Affinity Capture-MS

Homo sapiens

DNAJC9

23234

Proximity Label-MS

Homo sapiens

ZNF346

Affinity Capture-MS

Homo sapiens

ZNF320

Affinity Capture-MS

Homo sapiens

KIAA0020

9933

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

RSL24D1

Affinity Capture-MS

Homo sapiens

GTPBP10

Affinity Capture-MS

Homo sapiens

LHX2

Proximity Label-MS

Homo sapiens

RPL13A

23521

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

RPL37A

6168

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

RPL10

6134

Affinity Capture-MS

Homo sapiens

CHCHD1

Proximity Label-MS

Homo sapiens

RPL14

9045

Affinity Capture-MS

Homo sapiens

CSNK2A1

1457

Affinity Capture-MS

Homo sapiens

CAND1

55832

Affinity Capture-MS

Homo sapiens

SOX2

Proximity Label-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

DNAJB6

10049

Proximity Label-MS

Homo sapiens

USP36

Affinity Capture-MS

Homo sapiens

KIF20A

10112

Affinity Capture-MS

Homo sapiens

GPATCH4

54865

Affinity Capture-MS

Homo sapiens

HIST1H1A

3024

Affinity Capture-MS

Homo sapiens

MRPS10

55173

Affinity Capture-MS

Homo sapiens

PRR11

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

TFAM

7019

Affinity Capture-MS

Homo sapiens

CCDC137

Affinity Capture-MS

Homo sapiens

EGR2

Two-hybrid

Homo sapiens

NPM1

4869

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

WDR12

55759

Affinity Capture-MS

Homo sapiens

H2AFY2

55506

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

MAD2L2

10459

Proximity Label-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

RPS9

6203

Affinity Capture-MS

Homo sapiens

PRC1

9055

Affinity Capture-MS

Homo sapiens

ADARB1

104

Affinity Capture-MS

Homo sapiens

PRKRA

8575

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

BRD4

23476

Affinity Capture-MS

Homo sapiens

NOC3L

64318

Affinity Capture-MS

Homo sapiens

DDX18

8886

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

RPS3A

6189

Affinity Capture-MS

Homo sapiens

MRPS7

51081

Affinity Capture-MS

Homo sapiens

CUL1

8454

Affinity Capture-MS

Homo sapiens

CCNDBP1

23582

Two-hybrid

Homo sapiens

MYCN

Affinity Capture-MS

Homo sapiens

OBSL1

23363

Affinity Capture-MS

Homo sapiens

KIF14

9928

Affinity Capture-MS

Homo sapiens

PES1

23481

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

LIN28A

Affinity Capture-MS

Homo sapiens

CHMP4C

92421

Affinity Capture-MS

Homo sapiens

POP1

10940

Affinity Capture-MS

Homo sapiens

DDX31

Affinity Capture-MS

Homo sapiens

YBX1

4904

Affinity Capture-MS

Homo sapiens

RPL30

6156

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

HIST1H4A

8359

Affinity Capture-MS

Homo sapiens

DDX21

9188

Affinity Capture-MS

Homo sapiens

RPL4

6124

Affinity Capture-MS

Homo sapiens

RBM28

55131

Affinity Capture-MS

Homo sapiens

ZBTB47

Affinity Capture-MS

Homo sapiens

RBM4B

Affinity Capture-MS

Homo sapiens

SRSF6

6431

Affinity Capture-MS

Homo sapiens

Srp72

Affinity Capture-MS

Mus musculus

RPS10

6204

Affinity Capture-MS

Homo sapiens

RPL31

6160

Affinity Capture-MS

Homo sapiens

HIST1H1E

3008

Affinity Capture-MS

Homo sapiens

REXO4

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

RPL36

25873

Affinity Capture-MS

Homo sapiens

DHX29

54505

Affinity Capture-MS

Homo sapiens

LYAR

55646

Affinity Capture-MS

Homo sapiens

HECTD1

25831

Affinity Capture-MS

Homo sapiens

RPLP0

6175

Affinity Capture-MS

Homo sapiens

RRP1B

23076

Affinity Capture-MS

Homo sapiens

MAGEB2

4113

Affinity Capture-MS

Homo sapiens

MYBBP1A

10514

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

KLF12

Proximity Label-MS

Homo sapiens

GTPBP4

23560

Affinity Capture-MS

Homo sapiens

GLTSCR2

Affinity Capture-MS

Homo sapiens

RPL29

6159

Affinity Capture-MS

Homo sapiens

PIPSL

266971

Affinity Capture-MS

Homo sapiens

RPL11

6135

Affinity Capture-MS

Homo sapiens

RSL1D1

26156

Affinity Capture-MS

Homo sapiens

CNBP

7555

Affinity Capture-MS

Homo sapiens

ANLN

54443

Affinity Capture-MS

Homo sapiens

FGFBP1

9982

Affinity Capture-MS

Homo sapiens

ZBTB2

57621

Affinity Capture-MS

Homo sapiens

HADHB

3032

Affinity Capture-MS

Homo sapiens

ABT1

29777

Affinity Capture-MS

Homo sapiens

RPS2

6187

Affinity Capture-MS

Homo sapiens

BAZ1B

9031

Affinity Capture-MS

Homo sapiens

PTPN6

5777

Affinity Capture-MS

Homo sapiens

ZBTB24

Affinity Capture-MS

Homo sapiens

RPL35

11224

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

SRSF1

6426

Affinity Capture-MS

Homo sapiens

SRSF5

6430

Affinity Capture-MS

Homo sapiens

NPM3

10360

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

Rbm14

Two-hybrid

Mus musculus

UBC

7316

Reconstituted Complex

Homo sapiens

CUL3

8452

Affinity Capture-MS

Homo sapiens

RPS8

6202

Affinity Capture-MS

Homo sapiens

100

WDR55

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

101

RPL3

6122

Affinity Capture-MS

Homo sapiens

102

EGFR

1956

Negative Genetic

Homo sapiens

103

FGF1

Affinity Capture-MS

Homo sapiens

104

ZC3H10

Affinity Capture-MS

Homo sapiens

105

MYC

Affinity Capture-MS

Homo sapiens

106

RPA3

6119

Proximity Label-MS

Homo sapiens

107

RPS13

6207

Affinity Capture-MS

Homo sapiens

108

MAGEB10

Affinity Capture-MS

Homo sapiens

109

ZCCHC6

79670

Affinity Capture-MS

Homo sapiens

110

SET

6418

Affinity Capture-MS

Homo sapiens

111

MAGEA4

4103

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

112

CSNK2A2

1459

Affinity Capture-MS

Homo sapiens

113

RPS14

6208

Affinity Capture-MS

Homo sapiens

114

SART3

9733

Affinity Capture-MS

Homo sapiens

115

ZNF724P

Affinity Capture-MS

Homo sapiens

116

RPL23A

6147

Affinity Capture-MS

Homo sapiens

117

DDRGK1

65992

Affinity Capture-MS

Homo sapiens

118

RNF2

Affinity Capture-MS

Homo sapiens

119

NOP16

51491

Affinity Capture-MS

Homo sapiens

120

CCDC140

Affinity Capture-MS

Homo sapiens

121

ZC3H3

Affinity Capture-MS

Homo sapiens

122

BRD3

8019

Affinity Capture-MS

Homo sapiens

123

RPL15

6138

Affinity Capture-MS

Homo sapiens

124

RPL19

6143

Affinity Capture-MS

Homo sapiens

125

ZNF574

Affinity Capture-MS

Homo sapiens

126

FTL

2512

Affinity Capture-MS

Homo sapiens

127

RPL13

6137

Affinity Capture-MS

Homo sapiens

128

YTHDC2

64848

Affinity Capture-MS

Homo sapiens

129

SURF6

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

130

ARRB2

409

Affinity Capture-MS

Homo sapiens

131

PLEKHA4

57664

Affinity Capture-MS

Homo sapiens

132

RNF151

Affinity Capture-MS

Homo sapiens

133

PARP1

142

Affinity Capture-MS		Homo sapiens
Proximity Label-MS		Homo sapiens

134

ILF3

3609

Affinity Capture-MS

Homo sapiens

135

BOP1

23246

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

136

DGCR8

Affinity Capture-MS

Homo sapiens

137

ZNF48

Affinity Capture-MS

Homo sapiens

138

HIST1H2BD

3017

Affinity Capture-MS

Homo sapiens

139

DDX58

23586

Affinity Capture-RNA

Homo sapiens

140

NIFK

84365

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

141

DDX27

55661

Affinity Capture-MS

Homo sapiens

142

UFL1

23376

Affinity Capture-MS

Homo sapiens

143

KRR1

11103

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

144

ERGIC2

51290

Proximity Label-MS

Homo sapiens

145

NEIL1

Affinity Capture-MS

Homo sapiens

146

NOC2L

26155

Affinity Capture-MS

Homo sapiens

147

ARRB1

408

Affinity Capture-MS

Homo sapiens

148

RPL7A

6130

Affinity Capture-MS

Homo sapiens

149

RPS6

6194

Affinity Capture-MS

Homo sapiens

150

RPL8

6132

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

151

RPL28

6158

Affinity Capture-MS

Homo sapiens

152

CUL7

9820

Affinity Capture-MS

Homo sapiens

153

KRAS

3845

Negative Genetic

Homo sapiens

154

RBM34

Affinity Capture-MS

Homo sapiens

155

REPIN1

Affinity Capture-MS

Homo sapiens

156

DDX56

Affinity Capture-MS

Homo sapiens

157

RPL17

6139

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

View the network

Pathways in which RPL7L1 is involved
No pathways found

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