Gene description for SOS2
Gene name son of sevenless homolog 2 (Drosophila)
Gene symbol SOS2
Other names/aliases -
Species Homo sapiens
 Database cross references - SOS2
ExoCarta ExoCarta_6655
Vesiclepedia VP_6655
Entrez Gene 6655
HGNC 11188
MIM 601247
UniProt Q07890  
 SOS2 identified in sEVs derived from the following tissue/cell type
Hepatocellular carcinoma cells 26054723    
 Gene ontology annotations for SOS2
Molecular Function
    guanyl-nucleotide exchange factor activity GO:0005085 IBA
    protein binding GO:0005515 IPI
    protein heterodimerization activity GO:0046982 IEA
Biological Process
    B cell homeostasis GO:0001782 IEA
    Ras protein signal transduction GO:0007265 IBA
    insulin receptor signaling pathway GO:0008286 IEA
    regulation of T cell differentiation in thymus GO:0033081 IEA
    regulation of T cell proliferation GO:0042129 IEA
    positive regulation of small GTPase mediated signal transduction GO:0051057 IEA
    regulation of pro-B cell differentiation GO:2000973 IEA
Subcellular Localization
    cytosol GO:0005829 TAS
    plasma membrane GO:0005886 IBA
 Experiment description of studies that identified SOS2 in sEVs
1
Experiment ID 235
MISEV standards
EM
Biophysical techniques
TSG101|Alix|HSC70|GAPDH
Enriched markers
HSP90B1
Negative markers
qNano
Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors "He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N"
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocellular carcinoma cells
Sample name HKCI-8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RT-PCR
RNA Sequencing
 Protein-protein interactions for SOS2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 ZNF326 284695
Affinity Capture-MS Homo sapiens
2 GRAP2 9402
Reconstituted Complex Homo sapiens
3 HSPE1 3336
Affinity Capture-MS Homo sapiens
4 MCM7 4176
Affinity Capture-MS Homo sapiens
5 PPP1R9B 84687
Affinity Capture-MS Homo sapiens
6 NCK1 4690
Affinity Capture-MS Homo sapiens
7 GRB2 2885
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
8 SHC1 6464
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
9 TP53 7157
Affinity Capture-MS Homo sapiens
10 EIF6 3692
Affinity Capture-MS Homo sapiens
11 CRK 1398
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
12 TPX2  
Affinity Capture-MS Homo sapiens
13 ZC3H14  
Affinity Capture-MS Homo sapiens
14 SAP18 10284
Affinity Capture-MS Homo sapiens
15 UBA1 7317
Affinity Capture-MS Homo sapiens
16 PDIA3 2923
Affinity Capture-MS Homo sapiens
17 EGFR 1956
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
PCA Homo sapiens
Affinity Capture-Western Homo sapiens
18 KPNA2 3838
Affinity Capture-MS Homo sapiens
19 FUBP3 8939
Affinity Capture-MS Homo sapiens
20 RBM15 64783
Affinity Capture-MS Homo sapiens
21 DUT 1854
Affinity Capture-MS Homo sapiens
22 CWC15  
Affinity Capture-MS Homo sapiens
23 ESR1  
Affinity Capture-Western Homo sapiens
24 CREBBP  
Two-hybrid Homo sapiens
25 CKB 1152
Affinity Capture-MS Homo sapiens
26 GLO1 2739
Affinity Capture-MS Homo sapiens
27 ITSN2 50618
Two-hybrid Homo sapiens
28 ALDH18A1 5832
Affinity Capture-MS Homo sapiens
29 LRRK1 79705
Affinity Capture-MS Homo sapiens
30 TAGLN2 8407
Affinity Capture-MS Homo sapiens
31 EVI5L  
Affinity Capture-MS Homo sapiens
32 NTRK1 4914
Affinity Capture-MS Homo sapiens
33 CRKL 1399
Affinity Capture-MS Homo sapiens
34 TPI1 7167
Affinity Capture-MS Homo sapiens
35 SF3B6 51639
Affinity Capture-MS Homo sapiens
36 PABPN1 8106
Affinity Capture-MS Homo sapiens
37 NOP16 51491
Affinity Capture-MS Homo sapiens
38 MCCC1 56922
Affinity Capture-MS Homo sapiens
39 PLCG1 5335
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
40 BIN1 274
Reconstituted Complex Homo sapiens
41 SERPINH1 871
Affinity Capture-MS Homo sapiens
View the network image/svg+xml



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