Experiment description of studies that identified WWC3 in sEVs

1 Experiment ID 235 MISEV standards ✔ EM Biophysical techniques ✔ TSG101|Alix|HSC70|GAPDH Enriched markers ✔ HSP90B1 Negative markers ✔ qNano Particle analysis Identified molecule mRNA Identification method RNA Sequencing PubMed ID 26054723     Organism Homo sapiens Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs Authors "He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N" Journal name Carcinogenesis Publication year 2015 Sample Hepatocellular carcinoma cells Sample name HKCI-8 Isolation/purification methods Differential centrifugation Filtration Ultracentrifugation Sucrose density gradient Flotation density 1.13-1.19 g/mL Molecules identified in the study Protein RNA Methods used in the study Western blotting Mass spectrometry RT-PCR RNA Sequencing

Protein-protein interactions for WWC3

Protein Interactor ExoCarta ID Identification method PubMed Species 1 APP 351 Reconstituted Complex Homo sapiens 2 LATS1   Affinity Capture-Western Homo sapiens Affinity Capture-Western Homo sapiens Affinity Capture-Western Homo sapiens 3 LATS2 26524 Affinity Capture-Western Homo sapiens 4 Yap1   Reconstituted Complex Mus musculus 5 WWC2   Two-hybrid Homo sapiens Affinity Capture-Western Homo sapiens 6 WBP2 23558 Affinity Capture-Western Homo sapiens Affinity Capture-Western Homo sapiens Reconstituted Complex Homo sapiens 7 WWC3 55841 Two-hybrid Homo sapiens Two-hybrid Homo sapiens 8 DLC1 10395 Affinity Capture-Western Homo sapiens 9 YAP1 10413 Affinity Capture-MS Homo sapiens 10 PRKCA 5578 Affinity Capture-Western Homo sapiens Affinity Capture-Western Homo sapiens 11 WWC1   Two-hybrid Homo sapiens Affinity Capture-Western Homo sapiens 12 KIAA1524 57650 Two-hybrid Homo sapiens View the network

Pathways in which WWC3 is involved

No pathways found