Gene description for BIN3
Gene name bridging integrator 3
Gene symbol BIN3
Other names/aliases -
Species Homo sapiens
 Database cross references - BIN3
ExoCarta ExoCarta_55909
Vesiclepedia VP_55909
Entrez Gene 55909
HGNC 1054
MIM 606396
UniProt Q9NQY0  
 BIN3 identified in sEVs derived from the following tissue/cell type
Mesenchymal stem cells 36408942    
 Gene ontology annotations for BIN3
Molecular Function
    protein binding GO:0005515 IPI
    cytoskeletal anchor activity GO:0008093 NAS
    lipid binding GO:0008289 IBA
Biological Process
    endocytosis GO:0006897 IBA
    actin filament organization GO:0007015 NAS
    protein localization GO:0008104 IMP
    unidimensional cell growth GO:0009826 IMP
    regulation of lamellipodium assembly GO:0010591 IEA
    myoblast migration involved in skeletal muscle regeneration GO:0014839 IEA
    skeletal muscle fiber development GO:0048741 IEA
    actin cortical patch localization GO:0051666 IBA
    cytoskeleton-dependent cytokinesis GO:0061640 NAS
    plasma membrane tubulation GO:0097320 IBA
Subcellular Localization
    cytoplasm GO:0005737 IEA
    actin cytoskeleton GO:0015629 IBA
 Experiment description of studies that identified BIN3 in sEVs
1
Experiment ID 488
MISEV standards
EM
Biophysical techniques
CD9|CD81|CD63|GAPDH|SDCBP|LAMP1|TFRC|UCHL1|FLOT2|LAMP2|FLOT1|ICAM1|RAB5B|CD151|RAB35|TSG101|RAB5A|CD82
Enriched markers
CANX
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for BIN3
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 FBXO8  
Affinity Capture-MS Homo sapiens
2 SNX1 6642
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
3 SEC63 11231
Affinity Capture-MS Homo sapiens
4 PICK1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
5 GTF3C3 9330
Affinity Capture-MS Homo sapiens
6 PEX11B 8799
Affinity Capture-MS Homo sapiens
7 NXF1 10482
Two-hybrid Homo sapiens
8 AZU1 566
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
9 XPO1 7514
Affinity Capture-MS Homo sapiens
10 SNX33 257364
Affinity Capture-MS Homo sapiens
11 ERH 2079
Affinity Capture-MS Homo sapiens
12 ARHGEF37  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
13 C14orf119  
Two-hybrid Homo sapiens
14 POLR1C 9533
Two-hybrid Homo sapiens
15 NME2P1 283458
Affinity Capture-MS Homo sapiens
16 RIN3  
Affinity Capture-MS Homo sapiens
17 DNMBP 23268
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
18 UBL5 59286
Two-hybrid Homo sapiens
19 TRIM69 140691
Two-hybrid Homo sapiens
20 SHMT2 6472
Affinity Capture-RNA Homo sapiens
21 Vps4b 20479
Affinity Capture-MS Mus musculus
22 COG1 9382
Affinity Capture-MS Homo sapiens
23 Spred2  
Affinity Capture-MS Mus musculus
24 ABI2 10152
Two-hybrid Homo sapiens
25 GTF3C6  
Affinity Capture-MS Homo sapiens
26 TJP2 9414
Affinity Capture-MS Homo sapiens
27 PYGB 5834
Affinity Capture-MS Homo sapiens
28 SORT1 6272
Affinity Capture-MS Homo sapiens
29 TOP1 7150
Affinity Capture-MS Homo sapiens
30 SYNCRIP 10492
Affinity Capture-MS Homo sapiens
31 RPRD1B 58490
Two-hybrid Homo sapiens
32 BICD2 23299
Proximity Label-MS Homo sapiens
33 PCM1 5108
Affinity Capture-MS Homo sapiens
34 COG7 91949
Affinity Capture-MS Homo sapiens
35 OSBPL1A 114876
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
36 SNX5 27131
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
37 GINS4  
Two-hybrid Homo sapiens
View the network image/svg+xml
 Pathways in which BIN3 is involved
No pathways found





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