Gene description for JPH3
Gene name junctophilin 3
Gene symbol JPH3
Other names/aliases CAGL237
HDL2
JP-3
JP3
TNRC22
Species Homo sapiens
 Database cross references - JPH3
ExoCarta ExoCarta_57338
Vesiclepedia VP_57338
Entrez Gene 57338
HGNC 14203
MIM 605268
UniProt Q8WXH2  
 JPH3 identified in sEVs derived from the following tissue/cell type
Neuroblastoma cells 25944692    
 Gene ontology annotations for JPH3
Molecular Function
    protein binding GO:0005515 IPI
Biological Process
    learning GO:0007612 IEA
    memory GO:0007613 IEA
    exploration behavior GO:0035640 IEA
    locomotion GO:0040011 IEA
    regulation of synaptic plasticity GO:0048167 IBA
    regulation of neuronal synaptic plasticity GO:0048168 IEA
    neuromuscular process controlling balance GO:0050885 IEA
    regulation of ryanodine-sensitive calcium-release channel activity GO:0060314 TAS
    calcium ion transport into cytosol GO:0060402 TAS
Subcellular Localization
    endoplasmic reticulum membrane GO:0005789 IBA
    plasma membrane GO:0005886 IBA
    junctional sarcoplasmic reticulum membrane GO:0014701 TAS
    membrane GO:0016020 NAS
    junctional membrane complex GO:0030314 IBA
 Experiment description of studies that identified JPH3 in sEVs
1
Experiment ID 224
MISEV standards
EM|AFM
Biophysical techniques
Alix|TSG101|CD63|CD81
Enriched markers
GOLGA2
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25944692    
Organism Homo sapiens
Experiment description Proteogenomic analysis reveals exosomes are more oncogenic than ectosomes
Authors "Keerthikumar S, Gangoda L, Liem M, Fonseka P, Atukorala I, Ozcitti C, Mechler A, Adda CG, Ang CS, Mathivanan S"
Journal name Oncotarget
Publication year 2015
Sample Neuroblastoma cells
Sample name SH-SY5Y
Isolation/purification methods Differential centrifugation
Ultracentrifugation
OptiPrep density gradient
Flotation density 1.10 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
Western blotting
 Protein-protein interactions for JPH3
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 DDX46 9879
Affinity Capture-MS Homo sapiens
2 LIMA1 51474
Affinity Capture-MS Homo sapiens
3 RRP36 88745
Affinity Capture-MS Homo sapiens
4 STK24 8428
Affinity Capture-MS Homo sapiens
5 BGN 633
Reconstituted Complex Homo sapiens
6 C11orf57  
Affinity Capture-MS Homo sapiens
7 SVIL 6840
Affinity Capture-MS Homo sapiens
8 RP9  
Affinity Capture-MS Homo sapiens
9 JPH4 84502
Affinity Capture-MS Homo sapiens
10 MAP9 79884
Affinity Capture-MS Homo sapiens
11 RBM15B  
Affinity Capture-MS Homo sapiens
12 TSHR 7253
Two-hybrid Homo sapiens
13 RYR2 6262
FRET Homo sapiens
14 SMO 6608
Two-hybrid Homo sapiens
15 PPP1CA 5499
Two-hybrid Homo sapiens
16 RBMXL1  
Affinity Capture-MS Homo sapiens
17 ESF1 51575
Affinity Capture-MS Homo sapiens
18 C9orf78 51759
Affinity Capture-MS Homo sapiens
19 DCAF13 25879
Affinity Capture-MS Homo sapiens
20 BRD2  
Affinity Capture-MS Homo sapiens
21 CWC25 54883
Affinity Capture-MS Homo sapiens
22 RAI14 26064
Affinity Capture-MS Homo sapiens
23 C17orf85  
Affinity Capture-MS Homo sapiens
24 KCNN4 3783
FRET Homo sapiens
25 TRIP12 9320
Affinity Capture-MS Homo sapiens
26 SFSWAP  
Affinity Capture-MS Homo sapiens
27 PPP1R9A  
Affinity Capture-MS Homo sapiens
28 SNIP1  
Affinity Capture-MS Homo sapiens
29 ACTR5 79913
Affinity Capture-MS Homo sapiens
30 PPP1R12A 4659
Affinity Capture-MS Homo sapiens
31 TJP2 9414
Affinity Capture-MS Homo sapiens
32 SAFB2 9667
Affinity Capture-MS Homo sapiens
33 GTF2F2 2963
Affinity Capture-MS Homo sapiens
34 KRTAP10-8  
Two-hybrid Homo sapiens
35 PRPF38B 55119
Affinity Capture-MS Homo sapiens
36 CCR2  
Two-hybrid Homo sapiens
37 CACNA1D  
FRET Homo sapiens
38 EEF1A2 1917
Affinity Capture-MS Homo sapiens
39 NCOA5  
Affinity Capture-MS Homo sapiens
40 UBTF 7343
Affinity Capture-MS Homo sapiens
41 SNRNP27  
Affinity Capture-MS Homo sapiens
42 ARGLU1  
Affinity Capture-MS Homo sapiens
43 MPRIP 23164
Affinity Capture-MS Homo sapiens
44 PLEKHG3 26030
Affinity Capture-MS Homo sapiens
45 PRPF38A 84950
Affinity Capture-MS Homo sapiens
46 ZNHIT3  
Affinity Capture-MS Homo sapiens
47 PPIG 9360
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which JPH3 is involved
No pathways found





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