Gene description for PLEKHG3
Gene name pleckstrin homology domain containing, family G (with RhoGef domain) member 3
Gene symbol PLEKHG3
Other names/aliases ARHGEF43
KIAA0599
Species Homo sapiens
 Database cross references - PLEKHG3
ExoCarta ExoCarta_26030
Vesiclepedia VP_26030
Entrez Gene 26030
HGNC 20364
UniProt A1L390  
 PLEKHG3 identified in sEVs derived from the following tissue/cell type
Mesenchymal stem cells Unpublished / Not applicable
 Gene ontology annotations for PLEKHG3
Molecular Function
    actin binding GO:0003779 IDA
    guanyl-nucleotide exchange factor activity GO:0005085 IBA
    guanyl-nucleotide exchange factor activity GO:0005085 TAS
    small GTPase binding GO:0031267 IBA
Biological Process
    regulation of cell migration GO:0030334 IMP
    regulation of small GTPase mediated signal transduction GO:0051056 TAS
    regulation of establishment of cell polarity GO:2000114 IBA
    regulation of establishment of cell polarity GO:2000114 IDA
Subcellular Localization
    cytosol GO:0005829 TAS
    cytoskeleton GO:0005856 IEA
 Experiment description of studies that identified PLEKHG3 in sEVs
1
Experiment ID 126
MISEV standards
✘ Biophysical techniques
✔
GAPDH
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry [LTQ-FT Ultra]
PubMed ID Unpublished / Not applicable
Organism Homo sapiens
Experiment description Mesenchymal Stem Cell Exosomes: The Future MSC-based Therapy?
Authors "Ruenn Chai Lai, Ronne Wee Yeh Yeo, Soon Sim Tan, Bin Zhang, Yijun Yin, Newman Siu Kwan Sze, Andre Choo, and Sai Kiang Lim"
Journal name Mesenchymal Stem Cell Therapy
Publication year 2011
Sample Mesenchymal stem cells
Sample name huES9.E1
Isolation/purification methods HPLC
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Antobody array
Mass spectrometry
 Protein-protein interactions for PLEKHG3
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 YWHAH 7533
Affinity Capture-MS Homo sapiens
2 EMCN  
Affinity Capture-MS Homo sapiens
3 STAG3L3  
Affinity Capture-MS Homo sapiens
4 HMGN3  
Affinity Capture-MS Homo sapiens
5 ANLN 54443
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
6 LIMA1 51474
Affinity Capture-MS Homo sapiens
7 LSP1 4046
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
8 MTMR10 54893
Affinity Capture-MS Homo sapiens
9 ANKFY1 51479
Affinity Capture-MS Homo sapiens
10 Tmod3 50875
Affinity Capture-MS Mus musculus
11 S100P 6286
Affinity Capture-MS Homo sapiens
12 SOX2  
Affinity Capture-MS Homo sapiens
13 Myh9 17886
Affinity Capture-MS Mus musculus
14 CSNK1A1L 122011
Affinity Capture-MS Homo sapiens
15 Lima1  
Affinity Capture-MS Mus musculus
16 ABRA  
Affinity Capture-MS Homo sapiens
17 KIF14 9928
Affinity Capture-MS Homo sapiens
18 SLC39A3  
Affinity Capture-MS Homo sapiens
19 JPH3 57338
Affinity Capture-MS Homo sapiens
20 POTEI 653269
Affinity Capture-MS Homo sapiens
21 ECT2 1894
Affinity Capture-MS Homo sapiens
22 LMNB2 84823
Affinity Capture-MS Homo sapiens
23 UBXN7 26043
Affinity Capture-MS Homo sapiens
24 ACTA2 59
Affinity Capture-MS Homo sapiens
25 AHNAK 79026
Affinity Capture-MS Homo sapiens
26 Calml3  
Affinity Capture-MS Mus musculus
27 Bmpr1a  
Affinity Capture-MS Mus musculus
28 Myo1c 17913
Affinity Capture-MS Mus musculus
29 DBN1 1627
Affinity Capture-MS Homo sapiens
30 NUDT21 11051
Affinity Capture-MS Homo sapiens
31 FOXA1  
Affinity Capture-MS Homo sapiens
32 MTMR14 64419
Affinity Capture-MS Homo sapiens
33 CAPZA2 830
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
34 CTTN 2017
Affinity Capture-MS Homo sapiens
35 AURKB 9212
Affinity Capture-MS Homo sapiens
36 MYO19  
Affinity Capture-MS Homo sapiens
37 GSN 2934
Affinity Capture-MS Homo sapiens
38 TMEM147 10430
Affinity Capture-MS Homo sapiens
39 SYDE2  
Affinity Capture-MS Homo sapiens
40 TMEM263 90488
Affinity Capture-MS Homo sapiens
41 Ppp6c 67857
Affinity Capture-MS Mus musculus
42 CALM1 801
Affinity Capture-MS Homo sapiens
43 MYO1C 4641
Affinity Capture-MS Homo sapiens
44 ACTBL2 345651
Affinity Capture-MS Homo sapiens
45 SPIN3  
Affinity Capture-MS Homo sapiens
46 CDC42 998
FRET Homo sapiens
47 IL13 3596
Affinity Capture-MS Homo sapiens
48 POTEE 445582
Affinity Capture-MS Homo sapiens
49 KDM1A 23028
Affinity Capture-MS Homo sapiens
50 TMOD2 29767
Affinity Capture-MS Homo sapiens
51 MYO1D 4642
Affinity Capture-MS Homo sapiens
52 CHMP4B 128866
Affinity Capture-MS Homo sapiens
53 MYC  
Affinity Capture-MS Homo sapiens
54 MYH9 4627
Affinity Capture-MS Homo sapiens
55 PPP1CB 5500
Affinity Capture-MS Homo sapiens
56 CIRBP 1153
Affinity Capture-MS Homo sapiens
57 RPS29 6235
Affinity Capture-MS Homo sapiens
58 FLNA 2316
Affinity Capture-MS Homo sapiens
59 CHCHD2  
Affinity Capture-MS Homo sapiens
60 SAA1 6288
Affinity Capture-MS Homo sapiens
61 Flot1 14251
Affinity Capture-MS Mus musculus
62 PNRC2  
Affinity Capture-MS Homo sapiens
63 S100B 6285
Affinity Capture-MS Homo sapiens
64 IQGAP1 8826
Affinity Capture-MS Homo sapiens
65 ACTB 60
Proximity Label-MS Homo sapiens
66 S100A2 6273
Affinity Capture-MS Homo sapiens
67 CALM3 808
Affinity Capture-MS Homo sapiens
68 RHOB 388
Proximity Label-MS Homo sapiens
69 Coro1c 23790
Affinity Capture-MS Mus musculus
70 YWHAG 7532
Affinity Capture-MS Homo sapiens
71 MDP1 145553
Affinity Capture-MS Homo sapiens
72 CHMP2B 25978
Affinity Capture-MS Homo sapiens
73 RARRES3  
Affinity Capture-MS Homo sapiens
74 LMNA 4000
Affinity Capture-MS Homo sapiens
75 SNRNP70 6625
Affinity Capture-MS Homo sapiens
76 SURF6  
Affinity Capture-MS Homo sapiens
77 KLHL21 9903
Affinity Capture-MS Homo sapiens
78 ZMYM2  
Affinity Capture-MS Homo sapiens
79 MYO18A 399687
Affinity Capture-MS Homo sapiens
80 Tpm1 22003
Affinity Capture-MS Mus musculus
81 CCDC8  
Affinity Capture-MS Homo sapiens
82 NXT1  
Affinity Capture-MS Homo sapiens
83 CGREF1 10669
Affinity Capture-MS Homo sapiens
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