Gene description for RAB40C
Gene name RAB40C, member RAS oncogene family
Gene symbol RAB40C
Other names/aliases RARL
RASL8C
Species Homo sapiens
 Database cross references - RAB40C
ExoCarta ExoCarta_57799
Vesiclepedia VP_57799
Entrez Gene 57799
HGNC 18285
UniProt Q96S21  
 RAB40C identified in sEVs derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
 Gene ontology annotations for RAB40C
Molecular Function
    GTPase activity GO:0003924 IBA
    GTP binding GO:0005525 IEA
    GDP binding GO:0019003 IEA
Biological Process
    exocytosis GO:0006887 IBA
    protein ubiquitination GO:0016567 IEA
    intracellular signal transduction GO:0035556 IEA
Subcellular Localization
    endosome GO:0005768 IBA
    Golgi apparatus GO:0005794 IDA
    lipid droplet GO:0005811 IDA
    plasma membrane GO:0005886 IBA
    synaptic vesicle GO:0008021 IBA
    perinuclear region of cytoplasm GO:0048471 IEA
 Experiment description of studies that identified RAB40C in sEVs
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for RAB40C
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 PPP6R3 55291
Affinity Capture-Western Homo sapiens
2 ARIH2 10425
Affinity Capture-MS Homo sapiens
3 Plin3  
Reconstituted Complex Mus musculus
4 CTU1 90353
Affinity Capture-MS Homo sapiens
5 TCEB1 6921
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
6 RAB40B  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
7 RAB40AL  
Affinity Capture-MS Homo sapiens
8 AHCYL1 10768
Affinity Capture-MS Homo sapiens
9 AMBRA1  
Affinity Capture-MS Homo sapiens
10 USP22 23326
Affinity Capture-MS Homo sapiens
11 PPM1B 5495
Affinity Capture-MS Homo sapiens
12 CUL5 8065
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
13 ISCA1  
Affinity Capture-MS Homo sapiens
14 RBX1 9978
Affinity Capture-MS Homo sapiens
15 PPP6R2 9701
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
16 RABGGTB 5876
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
17 ANKRD28 23243
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
18 RNF7  
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
19 PSMG2 56984
Affinity Capture-MS Homo sapiens
20 ANKRD52 283373
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
21 DCUN1D1 54165
Affinity Capture-MS Homo sapiens
22 DDA1  
Affinity Capture-MS Homo sapiens
23 RAB40C 57799
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
24 TCEB2 6923
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
25 PPP6C 5537
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
26 PDPR 55066
Affinity Capture-MS Homo sapiens
27 ERGIC1 57222
Affinity Capture-MS Homo sapiens
28 PPP6R1 22870
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
29 PDP1 54704
Affinity Capture-MS Homo sapiens
30 ANKRD44 91526
Affinity Capture-Western Homo sapiens
31 Ccdc64b  
Affinity Capture-Western Mus musculus
32 PPM1A 5494
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which RAB40C is involved
PathwayEvidenceSource
Metabolism of proteins TAS Reactome
Post-translational protein modification TAS Reactome
RAB geranylgeranylation TAS Reactome





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