Gene description for Sugt1
Gene name SGT1, suppressor of G2 allele of SKP1 (S. cerevisiae)
Gene symbol Sugt1
Other names/aliases 2410174K12Rik
SGT1
Species Mus musculus
 Database cross references - Sugt1
ExoCarta ExoCarta_67955
Vesiclepedia VP_67955
Entrez Gene 67955
UniProt Q9CX34  
 Sugt1 identified in sEVs derived from the following tissue/cell type
Colon cancer cells 37309723    
T-cell lymphoma cells 37309723    
 Gene ontology annotations for Sugt1
Molecular Function
    protein-folding chaperone binding GO:0051087 IEA
    lncRNA binding GO:0106222 IPI
Biological Process
    spindle organization GO:0007051 IMP
    skeletal muscle satellite cell proliferation GO:0014841 IDA
    skeletal muscle satellite cell proliferation GO:0014841 IMP
    regulation of protein stability GO:0031647 IEA
    regulation of protein stability GO:0031647 ISO
    kinetochore assembly GO:0051382 IMP
    kinetochore assembly GO:0051382 ISO
    kinetochore assembly GO:0051382 ISS
Subcellular Localization
    kinetochore GO:0000776 IDA
    nucleus GO:0005634 IEA
    cytoplasm GO:0005737 IDA
    protein-containing complex GO:0032991 ISO
 Experiment description of studies that identified Sugt1 in sEVs
1
Experiment ID 907
MISEV standards
✔
EM
Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
Enriched markers
✔
HSPA5
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample Colon cancer cells
Sample name C26
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 908
MISEV standards
✔
EM
Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
Enriched markers
✔
HSPA5
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample T-cell lymphoma cells
Sample name EL4
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for Sugt1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Skp1a 21402
Co-fractionation Mus musculus
2 Tmem173  
Proximity Label-MS Mus musculus
3 Hsp90ab1 15516
Co-fractionation Mus musculus
4 Hspa8 15481
Co-fractionation Mus musculus
5 Lrrc40  
Co-fractionation Mus musculus
6 Rpap3  
Co-fractionation Mus musculus
7 Aip  
Co-fractionation Mus musculus
8 Dpcd  
Co-fractionation Mus musculus
9 Fkbp4 14228
Co-fractionation Mus musculus
10 PLK1 5347
Biochemical Activity Homo sapiens
View the network image/svg+xml



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