ExoCarta: Gene summary

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Gene description for Zc3h15
Gene name	zinc finger CCCH-type containing 15
Gene symbol	Zc3h15
Other names/aliases	1700006A17Rik 1810012H02Rik 2610312B22Rik FM22 Ierepo4
Species	Mus musculus
Database cross references - Zc3h15
ExoCarta	ExoCarta_69082
Vesiclepedia	VP_69082
Entrez Gene	69082
UniProt	Q3TIV5
Zc3h15 identified in sEVs derived from the following tissue/cell type
Mast cells	17486113

Gene ontology annotations for Zc3h15

Molecular Function
	metal ion binding	GO:0046872	IEA
Biological Process
	cytoplasmic translation	GO:0002181	IBA
	cytokine-mediated signaling pathway	GO:0019221	IDA
	positive regulation of GTPase activity	GO:0043547	ISO
Subcellular Localization
	nucleus	GO:0005634	IEA
	cytosol	GO:0005829	IBA
	cytosol	GO:0005829	IEA
	cytosol	GO:0005829	ISO

Experiment description of studies that identified Zc3h15 in sEVs

Experiment ID

MISEV standards
✔ EM	Biophysical techniques
✔ CD63	Enriched markers
✘	Negative markers
✘	Particle analysis

Identified molecule

mrna

Identification method

Microarray

PubMed ID

17486113

Organism

Mus musculus
Homo sapiens

Experiment description

Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells.

Authors

"Valadi H, Ekstrom K, Bossios A, Sjostrand M, Lee JJ, Lotvall JO"

Journal name

NCB

Publication year

2007

Sample

Mast cells

Sample name

MC9
Bone marrow-derived mast cells
HMC-1

Isolation/purification methods

Filtration
Ultracentrifugation
Sucrose density gradient

Flotation density

1.11-1.21 g/mL

Molecules identified in the study

Protein
mRNA
miRNA

Methods used in the study

Mass spectrometry [MALDI TOF]
Western blotting
Microarray
miRCURY LNA Array

Protein-protein interactions for Zc3h15

Protein Interactor

ExoCarta ID

Identification method

PubMed

Species

3110082I17Rik

Co-fractionation

Mus musculus

Tnpo1

238799

Co-fractionation

Mus musculus

Tmem173

Proximity Label-MS

Mus musculus

Trmt11

Co-fractionation

Mus musculus

Drg1

Affinity Capture-Western		Mus musculus
Co-fractionation		Mus musculus

Prmt1

15469

Co-fractionation

Mus musculus

Prps2

110639

Co-fractionation

Mus musculus

Pwp1

Co-fractionation

Mus musculus

View the network

Pathways in which Zc3h15 is involved

Pathway	Evidence	Source
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation	IEA	Reactome
Metabolism of proteins	IEA	Reactome
Post-translational protein modification	IEA	Reactome
Protein hydroxylation	IEA	Reactome

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