Gene description for TNS1
Gene name tensin 1
Gene symbol TNS1
Other names/aliases MST091
MST122
MST127
MSTP091
MSTP122
MSTP127
MXRA6
PPP1R155
TNS
Species Homo sapiens
 Database cross references - TNS1
ExoCarta ExoCarta_7145
Vesiclepedia VP_7145
Entrez Gene 7145
HGNC 11973
MIM 600076
UniProt Q9HBL0  
 TNS1 identified in sEVs derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Mesenchymal stem cells 36408942    
 Gene ontology annotations for TNS1
Molecular Function
    RNA binding GO:0003723 HDA
    actin binding GO:0003779 IEA
    phosphoprotein phosphatase activity GO:0004721 IEA
    protein binding GO:0005515 IPI
    metal ion binding GO:0046872 IEA
Biological Process
    cell-substrate junction assembly GO:0007044 IEA
    fibroblast migration GO:0010761 IBA
Subcellular Localization
    cytoplasm GO:0005737 IEA
    cytoskeleton GO:0005856 IEA
    focal adhesion GO:0005925 HDA
    focal adhesion GO:0005925 IBA
    focal adhesion GO:0005925 IDA
    cell surface GO:0009986 IEA
 Experiment description of studies that identified TNS1 in sEVs
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
5
Experiment ID 488
MISEV standards
✔
EM
Biophysical techniques
✔
CD9|CD81|CD63|GAPDH|SDCBP|LAMP1|TFRC|UCHL1|FLOT2|LAMP2|FLOT1|ICAM1|RAB5B|CD151|RAB35|TSG101|RAB5A|CD82
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for TNS1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 UTRN 7402
Affinity Capture-MS Homo sapiens
2 FAM175B 23172
Affinity Capture-MS Homo sapiens
3 ERBB2 2064
Reconstituted Complex Homo sapiens
4 CSK 1445
Affinity Capture-MS Homo sapiens
5 SNTB2 6645
Affinity Capture-MS Homo sapiens
6 KCNC3 3748
Affinity Capture-MS Homo sapiens
7 BABAM1 29086
Affinity Capture-MS Homo sapiens
8 BCAR1 9564
Affinity Capture-Western Homo sapiens
9 KIT 3815
Reconstituted Complex Homo sapiens
10 YWHAZ 7534
Two-hybrid Homo sapiens
11 ERBB4 2066
Reconstituted Complex Homo sapiens
12 EGFR 1956
Reconstituted Complex Homo sapiens
13 OSGEP 55644
Two-hybrid Homo sapiens
14 NPHP1  
Affinity Capture-Western Homo sapiens
15 ERBB3 2065
Reconstituted Complex Homo sapiens
16 GAB1  
Reconstituted Complex Homo sapiens
17 PPP1CC 5501
Two-hybrid Homo sapiens
18 DTNB 1838
Affinity Capture-MS Homo sapiens
19 TNS2 23371
Affinity Capture-MS Homo sapiens
20 MET 4233
Reconstituted Complex Homo sapiens
21 SORBS3 10174
Affinity Capture-MS Homo sapiens
22 BRCC3 79184
Affinity Capture-MS Homo sapiens
23 KLF10  
Two-hybrid Homo sapiens
24 AR 367
Reconstituted Complex Homo sapiens
25 DMD 1756
Affinity Capture-MS Homo sapiens
26 SNTB1 6641
Affinity Capture-MS Homo sapiens
27 CTNNAL1 8727
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which TNS1 is involved
No pathways found





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