Gene description for TYRO3
Gene name TYRO3 protein tyrosine kinase
Gene symbol TYRO3
Other names/aliases BYK
Dtk
Etk-2
RSE
Rek
Sky
Tif
Species Homo sapiens
 Database cross references - TYRO3
ExoCarta ExoCarta_7301
Vesiclepedia VP_7301
Entrez Gene 7301
HGNC 12446
MIM 600341
UniProt Q06418  
 TYRO3 identified in sEVs derived from the following tissue/cell type
Mesenchymal stem cells 36408942    
 Gene ontology annotations for TYRO3
Molecular Function
    virus receptor activity GO:0001618 IDA
    protein tyrosine kinase activity GO:0004713 IDA
    transmembrane receptor protein tyrosine kinase activity GO:0004714 IBA
    transmembrane receptor protein tyrosine kinase activity GO:0004714 NAS
    GPI-linked ephrin receptor activity GO:0005004 IEA
    transmembrane-ephrin receptor activity GO:0005005 IEA
    epidermal growth factor receptor activity GO:0005006 IEA
    fibroblast growth factor receptor activity GO:0005007 IEA
    hepatocyte growth factor receptor activity GO:0005008 IEA
    insulin receptor activity GO:0005009 IEA
    insulin-like growth factor receptor activity GO:0005010 IEA
    macrophage colony-stimulating factor receptor activity GO:0005011 IEA
    platelet-derived growth factor alpha-receptor activity GO:0005018 IEA
    platelet-derived growth factor beta-receptor activity GO:0005019 IEA
    stem cell factor receptor activity GO:0005020 IEA
    vascular endothelial growth factor receptor activity GO:0005021 IEA
    protein binding GO:0005515 IPI
    ATP binding GO:0005524 IEA
    boss receptor activity GO:0008288 IEA
    histone H3Y41 kinase activity GO:0035401 IEA
    placental growth factor receptor activity GO:0036332 IEA
    protein tyrosine kinase collagen receptor activity GO:0038062 IEA
    phosphatidylinositol 3-kinase binding GO:0043548 IPI
    brain-derived neurotrophic factor receptor activity GO:0060175 IEA
    histone H2AXY142 kinase activity GO:0140801 IEA
Biological Process
    neuron migration GO:0001764 IEA
    natural killer cell differentiation GO:0001779 IEA
    chromatin remodeling GO:0006338 IEA
    phagocytosis GO:0006909 IBA
    cell adhesion GO:0007155 NAS
    signal transduction GO:0007165 NAS
    cell surface receptor protein tyrosine kinase signaling pathway GO:0007169 IBA
    epidermal growth factor receptor signaling pathway GO:0007173 IEA
    neuropeptide signaling pathway GO:0007218 IEA
    multicellular organism development GO:0007275 IBA
    spermatogenesis GO:0007283 ISS
    nervous system development GO:0007399 IBA
    insulin receptor signaling pathway GO:0008286 IEA
    fibroblast growth factor receptor signaling pathway GO:0008543 IEA
    cell migration GO:0016477 IBA
    forebrain cell migration GO:0021885 ISS
    platelet activation GO:0030168 ISS
    brain-derived neurotrophic factor receptor signaling pathway GO:0031547 IEA
    secretion by cell GO:0032940 ISS
    negative regulation of toll-like receptor signaling pathway GO:0034122 ISS
    substrate adhesion-dependent cell spreading GO:0034446 ISS
    platelet-derived growth factor receptor-alpha signaling pathway GO:0035790 IEA
    platelet-derived growth factor receptor-beta signaling pathway GO:0035791 IEA
    vascular endothelial growth factor receptor-1 signaling pathway GO:0036323 IEA
    collagen-activated tyrosine kinase receptor signaling pathway GO:0038063 IEA
    vascular endothelial growth factor signaling pathway GO:0038084 IEA
    Kit signaling pathway GO:0038109 IEA
    macrophage colony-stimulating factor signaling pathway GO:0038145 IEA
    ovulation cycle GO:0042698 ISS
    apoptotic cell clearance GO:0043277 ISS
    phosphatidylinositol 3-kinase/protein kinase B signal transduction GO:0043491 NAS
    negative regulation of neuron apoptotic process GO:0043524 ISS
    negative regulation of innate immune response GO:0045824 ISS
    symbiont entry into host cell GO:0046718 IEA
    protein autophosphorylation GO:0046777 IDA
    insulin-like growth factor receptor signaling pathway GO:0048009 IEA
    hepatocyte growth factor receptor signaling pathway GO:0048012 IEA
    ephrin receptor signaling pathway GO:0048013 IEA
    negative regulation of inflammatory response GO:0050728 ISS
    negative regulation of lymphocyte activation GO:0051250 IEA
    neuron apoptotic process GO:0051402 IEA
    establishment of localization in cell GO:0051649 IEA
    positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction GO:0051897 ISS
    vagina development GO:0060068 IEA
    neuron cellular homeostasis GO:0070050 ISS
    platelet aggregation GO:0070527 IBA
    platelet aggregation GO:0070527 ISS
    positive regulation of viral life cycle GO:1903902 IMP
Subcellular Localization
    nucleus GO:0005634 ISS
    nuclear envelope GO:0005635 ISS
    endoplasmic reticulum membrane GO:0005789 ISS
    plasma membrane GO:0005886 IBA
    plasma membrane GO:0005886 NAS
    cell surface GO:0009986 IDA
    receptor complex GO:0043235 IBA
 Experiment description of studies that identified TYRO3 in sEVs
1
Experiment ID 488
MISEV standards
✔
EM
Biophysical techniques
✔
CD9|CD81|CD63|GAPDH|SDCBP|LAMP1|TFRC|UCHL1|FLOT2|LAMP2|FLOT1|ICAM1|RAB5B|CD151|RAB35|TSG101|RAB5A|CD82
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for TYRO3
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 KRTAP10-7  
Two-hybrid Homo sapiens
2 AXL 558
Two-hybrid Homo sapiens
3 TNIP1 10318
Two-hybrid Homo sapiens
4 ERBB2 2064
PCA Homo sapiens
5 CHRNB3  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
6 CTDSP1 58190
Two-hybrid Homo sapiens
7 TP53BP1 7158
Negative Genetic Homo sapiens
8 KRTAP10-8  
Two-hybrid Homo sapiens
9 IKBKG 8517
Reconstituted Complex Homo sapiens
10 TMEM30B 161291
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
11 MDFI  
Two-hybrid Homo sapiens
12 APOE 348
Two-hybrid Homo sapiens
13 KRTAP5-9  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
14 HSP90AA1 3320
Affinity Capture-Luminescence Homo sapiens
15 KRTAP10-3  
Two-hybrid Homo sapiens
16 LPAR1 1902
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
17 A2M 2
Two-hybrid Homo sapiens
18 CTDSP2 10106
Two-hybrid Homo sapiens
19 MKRN2 23609
Affinity Capture-RNA Homo sapiens
20 KLK4  
Two-hybrid Homo sapiens
21 COPS5 10987
Affinity Capture-MS Homo sapiens
22 IPPK  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
23 KRT40  
Two-hybrid Homo sapiens
24 HDLBP 3069
Co-fractionation Homo sapiens
25 SRC 6714
Affinity Capture-Western Homo sapiens
26 PIK3R1 5295
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
27 KRTAP4-2  
Two-hybrid Homo sapiens
28 GAS6 2621
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
29 LNX1  
Two-hybrid Homo sapiens
30 Ttll12 223723
Affinity Capture-MS Mus musculus
31 KRTAP10-9  
Two-hybrid Homo sapiens
View the network image/svg+xml
 Pathways in which TYRO3 is involved
No pathways found





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