ExoCarta: Gene summary

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Gene description for Prss23
Gene name	protease, serine 23
Gene symbol	Prss23
Other names/aliases	2310046G15Rik 4930479H08Rik AI790574 Spuve
Species	Mus musculus
Database cross references - Prss23
ExoCarta	ExoCarta_76453
Vesiclepedia	VP_76453
Entrez Gene	76453
UniProt	Q9D6X6
Prss23 identified in sEVs derived from the following tissue/cell type
Neural stem cells	25242146

Gene ontology annotations for Prss23

Molecular Function
	serine-type endopeptidase activity	GO:0004252	IEA
Biological Process
	proteolysis	GO:0006508	IEA
Subcellular Localization
	extracellular space	GO:0005615	HDA
	nucleus	GO:0005634	IEA
	nucleus	GO:0005634	ISO

Experiment description of studies that identified Prss23 in sEVs

Experiment ID

263

MISEV standards
✘	Biophysical techniques
✔ CD63\|CD9	Enriched markers
✘	Negative markers
✘	Particle analysis

Identified molecule

protein

Identification method

Mass spectrometry

PubMed ID

25242146

Organism

Mus musculus

Experiment description

Extracellular Vesicles from Neural Stem Cells Transfer IFN-? via Ifngr1 to Activate Stat1 Signaling in Target Cells

Authors

"Chiara Cossetti, Nunzio Iraci, Tim R. Mercer, Tommaso Leonardi, Emanuele Alpi, Denise Drago, Clara Alfaro-Cervello, Harpreet K. Saini, Matthew P. Davis, Julia Schaeffer, Beatriz Vega, Matilde Stefanini, CongJian Zhao, Werner Muller, Jose Manuel Garcia-Verdugo, Suresh Mathivanan, Angela Bachi, Anton J. Enright, John S. Mattick, Stefano Pluchino"

Journal name

Molecular Cell

Publication year

2014

Sample

Neural stem cells

Sample name

NPCs - Th1 treated

Isolation/purification methods

Differential centrifugation
Ultracentrifugation
Sucrose density gradient

Flotation density

1.13-1.20 g/mL

Molecules identified in the study

Protein

Methods used in the study

Western blotting
Mass spectrometry

Protein-protein interactions for Prss23

Protein Interactor

ExoCarta ID

Identification method

PubMed

Species

Odf2l

Co-fractionation

Mus musculus

Grk6

26385

Co-fractionation

Mus musculus

Tcf12

21406

Co-fractionation

Mus musculus

View the network

Pathways in which Prss23 is involved

Pathway	Evidence	Source
Metabolism of proteins	IEA	Reactome
Post-translational protein modification	IEA	Reactome
Post-translational protein phosphorylation	IEA	Reactome
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)	IEA	Reactome

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