Gene description for Tcf12
Gene name transcription factor 12
Gene symbol Tcf12
Other names/aliases A130037E08Rik
ALF1
HEB
HEBAlt
HTF-4
HTF4
ME1
REB
bHLHb20
Species Mus musculus
 Database cross references - Tcf12
ExoCarta ExoCarta_21406
Vesiclepedia VP_21406
Entrez Gene 21406
UniProt Q61286  
 Tcf12 identified in sEVs derived from the following tissue/cell type
Mast cells 17486113    
 Gene ontology annotations for Tcf12
Molecular Function
    transcription cis-regulatory region binding GO:0000976 ISO
    RNA polymerase II cis-regulatory region sequence-specific DNA binding GO:0000978 IBA
    RNA polymerase II cis-regulatory region sequence-specific DNA binding GO:0000978 ISO
    DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981 IBA
    DNA-binding transcription activator activity, RNA polymerase II-specific GO:0001228 IEA
    DNA-binding transcription activator activity, RNA polymerase II-specific GO:0001228 ISO
    DNA binding GO:0003677 IDA
    DNA-binding transcription factor activity GO:0003700 ISO
    protein binding GO:0005515 IPI
    cAMP response element binding GO:0035497 IEA
    cAMP response element binding GO:0035497 ISO
    bHLH transcription factor binding GO:0043425 IEA
    bHLH transcription factor binding GO:0043425 ISO
    SMAD binding GO:0046332 IEA
    SMAD binding GO:0046332 ISO
    protein heterodimerization activity GO:0046982 IDA
    E-box binding GO:0070888 IDA
    HMG box domain binding GO:0071837 IEA
    HMG box domain binding GO:0071837 ISO
    DNA-binding transcription factor binding GO:0140297 ISO
    sequence-specific double-stranded DNA binding GO:1990837 ISO
Biological Process
    regulation of transcription by RNA polymerase II GO:0006357 IBA
    nervous system development GO:0007399 IEA
    gene expression GO:0010467 IMP
    positive regulation of gene expression GO:0010628 IMP
    cell differentiation GO:0030154 IEA
    positive regulation of neuron differentiation GO:0045666 IDA
    positive regulation of DNA-templated transcription GO:0045893 IDA
    positive regulation of transcription by RNA polymerase II GO:0045944 IEA
    positive regulation of transcription by RNA polymerase II GO:0045944 ISO
    response to gonadotropin-releasing hormone GO:0097210 ISO
    response to gonadotropin-releasing hormone GO:0097210 ISS
Subcellular Localization
    chromatin GO:0000785 IBA
    chromatin GO:0000785 IEA
    chromatin GO:0000785 ISO
    nucleus GO:0005634 ISO
    nucleoplasm GO:0005654 ISO
    transcription regulator complex GO:0005667 IBA
    transcription regulator complex GO:0005667 IDA
    cytoplasm GO:0005737 IEA
    cytoplasm GO:0005737 ISO
    nuclear speck GO:0016607 IEA
    nuclear speck GO:0016607 ISO
    intracellular membrane-bounded organelle GO:0043231 ISO
    RNA polymerase II transcription regulator complex GO:0090575 IEA
    RNA polymerase II transcription regulator complex GO:0090575 ISO
 Experiment description of studies that identified Tcf12 in sEVs
1
Experiment ID 15
MISEV standards
EM
Biophysical techniques
CD63
Enriched markers
Negative markers
Particle analysis
Identified molecule mrna
Identification method Microarray
PubMed ID 17486113    
Organism Mus musculus
Homo sapiens
Experiment description Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells.
Authors "Valadi H, Ekstrom K, Bossios A, Sjostrand M, Lee JJ, Lotvall JO"
Journal name NCB
Publication year 2007
Sample Mast cells
Sample name MC9
Bone marrow-derived mast cells
HMC-1
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.11-1.21 g/mL
Molecules identified in the study Protein
mRNA
miRNA
Methods used in the study Mass spectrometry [MALDI TOF]
Western blotting
Microarray
miRCURY LNA Array
 Protein-protein interactions for Tcf12
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Mga  
Co-fractionation Mus musculus
2 Id1  
Two-hybrid Mus musculus
3 Ep300  
Affinity Capture-Western Mus musculus
Co-fractionation Mus musculus
Affinity Capture-Western Mus musculus
4 Tcf4 21413
Reconstituted Complex Mus musculus
Reconstituted Complex Mus musculus
5 Tead1  
Co-fractionation Mus musculus
6 Prss23 76453
Co-fractionation Mus musculus
7 Arnt2  
Co-fractionation Mus musculus
8 Chd4 107932
Affinity Capture-Western Mus musculus
Affinity Capture-Western Mus musculus
9 Rbl2  
Co-fractionation Mus musculus
10 Tcf7l2  
Co-fractionation Mus musculus
11 Hand1  
Two-hybrid Mus musculus
12 Fos  
Co-fractionation Mus musculus
13 Nr4a3  
Co-fractionation Mus musculus
14 Tcf23  
Co-fractionation Mus musculus
15 Zeb1  
Co-fractionation Mus musculus
16 Id3  
Two-hybrid Mus musculus
17 Crebbp  
Co-fractionation Mus musculus
18 Sox8  
Affinity Capture-Western Mus musculus
19 Ascl3  
Two-hybrid Mus musculus
20 Epas1  
Co-fractionation Mus musculus
21 Twist1  
Proximity Label-MS Mus musculus
22 TCF3  
Reconstituted Complex Homo sapiens
23 Zbtb7b  
Affinity Capture-MS Mus musculus
24 ASCL3  
Two-hybrid Homo sapiens
25 Rbl1  
Co-fractionation Mus musculus
26 SRY  
Affinity Capture-Western Homo sapiens
27 Sox10  
Affinity Capture-Western Rattus norvegicus
28 Arnt  
Co-fractionation Mus musculus
29 Ascl1  
Two-hybrid Mus musculus
30 Lysmd1  
Co-fractionation Mus musculus
31 Tfdp1  
Co-fractionation Mus musculus
32 Fancd2  
Affinity Capture-MS Mus musculus
33 Tcf12 21406
Reconstituted Complex Mus musculus
Reconstituted Complex Mus musculus
34 Tcf3  
Reconstituted Complex Mus musculus
Reconstituted Complex Mus musculus
35 Hand2  
Reconstituted Complex Mus musculus
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