Gene description for MYL10
Gene name myosin, light chain 10, regulatory
Gene symbol MYL10
Other names/aliases MYLC2PL
PLRLC
Species Homo sapiens
 Database cross references - MYL10
ExoCarta ExoCarta_93408
Vesiclepedia VP_93408
Entrez Gene 93408
HGNC 29825
UniProt Q9BUA6  
 MYL10 identified in sEVs derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
 Gene ontology annotations for MYL10
Molecular Function
    calcium ion binding GO:0005509 IBA
    protein binding GO:0005515 IPI
Subcellular Localization
    cytoplasm GO:0005737 IBA
    mitochondrion GO:0005739 IBA
    mitochondrion GO:0005739 IDA
    cytosol GO:0005829 TAS
 Experiment description of studies that identified MYL10 in sEVs
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for MYL10
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 ZMYND19  
Affinity Capture-MS Homo sapiens
2 EARS2  
Affinity Capture-MS Homo sapiens
3 ADCK4 79934
Affinity Capture-MS Homo sapiens
4 BCKDK 10295
Affinity Capture-MS Homo sapiens
5 LARS2 23395
Affinity Capture-MS Homo sapiens
6 BTF3 689
Affinity Capture-MS Homo sapiens
7 MCCC1 56922
Affinity Capture-MS Homo sapiens
8 MYO19  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
9 ELAC2 60528
Affinity Capture-MS Homo sapiens
10 MTO1  
Affinity Capture-MS Homo sapiens
11 TMLHE 55217
Affinity Capture-MS Homo sapiens
12 APP 351
Reconstituted Complex Homo sapiens
13 CPS1 1373
Affinity Capture-MS Homo sapiens
14 CRAT 1384
Affinity Capture-MS Homo sapiens
15 DCAF6 55827
Affinity Capture-MS Homo sapiens
16 D2HGDH 728294
Affinity Capture-MS Homo sapiens
17 MIPEP  
Affinity Capture-MS Homo sapiens
18 TARS2 80222
Affinity Capture-MS Homo sapiens
19 ACSF3 197322
Affinity Capture-MS Homo sapiens
20 CYP24A1  
Affinity Capture-MS Homo sapiens
21 KIAA0391  
Affinity Capture-MS Homo sapiens
22 IQGAP1 8826
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
23 NARS2  
Affinity Capture-MS Homo sapiens
24 POLG  
Affinity Capture-MS Homo sapiens
25 MARS2 92935
Affinity Capture-MS Homo sapiens
26 DARS2 55157
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which MYL10 is involved
PathwayEvidenceSource
Muscle contraction TAS Reactome
Smooth Muscle Contraction TAS Reactome





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