Gene description for Ctnnb1
Gene name catenin (cadherin associated protein), beta 1
Gene symbol Ctnnb1
Other names/aliases Bfc
Catnb
Mesc
Species Mus musculus
 Database cross references - Ctnnb1
ExoCarta ExoCarta_12387
Vesiclepedia VP_12387
Entrez Gene 12387
UniProt Q02248  
 Ctnnb1 identified in sEVs derived from the following tissue/cell type
Colon cancer cells 37309723    
T-cell lymphoma cells 37309723    
 Gene ontology annotations for Ctnnb1
Molecular Function
    transcription coregulator binding GO:0001221 IPI
    transcription corepressor binding GO:0001222 IEA
    transcription corepressor binding GO:0001222 ISO
    nucleic acid binding GO:0003676 EXP
    chromatin binding GO:0003682 IDA
    chromatin binding GO:0003682 IGI
    transcription coactivator activity GO:0003713 IBA
    transcription coactivator activity GO:0003713 IDA
    transcription coactivator activity GO:0003713 IMP
    transcription coactivator activity GO:0003713 ISO
    signaling receptor binding GO:0005102 IEA
    signaling receptor binding GO:0005102 ISO
    protein binding GO:0005515 IPI
    transcription factor binding GO:0008134 IPI
    nuclear receptor binding GO:0016922 IBA
    nuclear receptor binding GO:0016922 IPI
    nuclear receptor binding GO:0016922 ISO
    enzyme binding GO:0019899 IPI
    enzyme binding GO:0019899 ISO
    kinase binding GO:0019900 ISO
    protein kinase binding GO:0019901 IPI
    protein phosphatase binding GO:0019903 IBA
    protein phosphatase binding GO:0019903 IPI
    nuclear estrogen receptor binding GO:0030331 IEA
    nuclear estrogen receptor binding GO:0030331 ISO
    ubiquitin protein ligase binding GO:0031625 ISO
    ionotropic glutamate receptor binding GO:0035255 ISO
    transmembrane transporter binding GO:0044325 IEA
    transmembrane transporter binding GO:0044325 ISO
    protein-containing complex binding GO:0044877 ISO
    alpha-catenin binding GO:0045294 IBA
    alpha-catenin binding GO:0045294 IDA
    alpha-catenin binding GO:0045294 IPI
    alpha-catenin binding GO:0045294 ISO
    cadherin binding GO:0045296 IBA
    cadherin binding GO:0045296 IPI
    cadherin binding GO:0045296 ISO
    SMAD binding GO:0046332 ISO
    nitric-oxide synthase binding GO:0050998 ISO
    RNA polymerase II-specific DNA-binding transcription factor binding GO:0061629 IDA
    RNA polymerase II-specific DNA-binding transcription factor binding GO:0061629 ISO
    delta-catenin binding GO:0070097 ISO
    I-SMAD binding GO:0070411 IEA
    I-SMAD binding GO:0070411 ISO
    disordered domain specific binding GO:0097718 IPI
    DNA-binding transcription factor binding GO:0140297 IPI
    DNA-binding transcription factor binding GO:0140297 ISO
    molecular function activator activity GO:0140677 EXP
    histone methyltransferase binding GO:1990226 IPI
Biological Process
    negative regulation of transcription by RNA polymerase II GO:0000122 IDA
    negative regulation of transcription by RNA polymerase II GO:0000122 IDA
    MAPK cascade GO:0000165 IGI
    protein polyubiquitination GO:0000209 IEA
    protein polyubiquitination GO:0000209 ISO
    embryonic axis specification GO:0000578 IDA
    cell morphogenesis GO:0000902 IMP
    skeletal system development GO:0001501 IMP
    branching involved in blood vessel morphogenesis GO:0001569 IMP
    branching involved in blood vessel morphogenesis GO:0001569 ISO
    vasculogenesis GO:0001570 IMP
    osteoblast differentiation GO:0001649 IMP
    osteoblast differentiation GO:0001649 ISO
    branching involved in ureteric bud morphogenesis GO:0001658 IMP
    in utero embryonic development GO:0001701 IGI
    in utero embryonic development GO:0001701 IMP
    gastrulation with mouth forming second GO:0001702 IMP
    endoderm formation GO:0001706 IMP
    cell fate specification GO:0001708 IMP
    endodermal cell fate commitment GO:0001711 IMP
    neuron migration GO:0001764 IGI
    kidney development GO:0001822 IMP
    neural plate development GO:0001840 IDA
    tissue homeostasis GO:0001894 IMP
    vasculature development GO:0001944 IMP
    positive regulation of neuroblast proliferation GO:0002052 IGI
    positive regulation of neuroblast proliferation GO:0002052 IMP
    positive regulation of mesenchymal cell proliferation GO:0002053 IMP
    chondrocyte differentiation GO:0002062 IGI
    chondrocyte differentiation GO:0002062 IMP
    glandular epithelial cell differentiation GO:0002067 IMP
    lens morphogenesis in camera-type eye GO:0002089 IMP
    outflow tract morphogenesis GO:0003151 IMP
    ventricular compact myocardium morphogenesis GO:0003223 TAS
    regulation of secondary heart field cardioblast proliferation GO:0003266 IDA
    metanephros morphogenesis GO:0003338 IMP
    negative regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis GO:0003340 IDA
    DNA-templated transcription GO:0006351 IMP
    regulation of transcription by RNA polymerase II GO:0006357 IDA
    regulation of transcription by RNA polymerase II GO:0006357 IMP
    transcription by RNA polymerase II GO:0006366 IDA
    cell adhesion GO:0007155 ISO
    cell adhesion GO:0007155 ISS
    cell-matrix adhesion GO:0007160 IMP
    chemical synaptic transmission GO:0007268 IMP
    ectoderm development GO:0007398 IMP
    glial cell fate determination GO:0007403 IDA
    neuroblast proliferation GO:0007405 IGI
    heart development GO:0007507 IMP
    protein localization GO:0008104 IMP
    cell population proliferation GO:0008283 IMP
    cell population proliferation GO:0008283 IMP
    positive regulation of cell population proliferation GO:0008284 IMP
    positive regulation of cell population proliferation GO:0008284 IMP
    negative regulation of cell population proliferation GO:0008285 ISO
    negative regulation of cell population proliferation GO:0008285 ISS
    fibroblast growth factor receptor signaling pathway GO:0008543 IMP
    response to xenobiotic stimulus GO:0009410 IEA
    anterior/posterior axis specification GO:0009948 IMP
    dorsal/ventral axis specification GO:0009950 IMP
    dorsal/ventral pattern formation GO:0009953 IMP
    proximal/distal pattern formation GO:0009954 IMP
    mesenchymal cell proliferation GO:0010463 IMP
    gene expression GO:0010467 IMP
    regulation of gene expression GO:0010468 IMP
    positive regulation of gene expression GO:0010628 IMP
    negative regulation of gene expression GO:0010629 IMP
    negative regulation of gene expression GO:0010629 ISO
    positive regulation of epithelial to mesenchymal transition GO:0010718 ISO
    positive regulation of epithelial to mesenchymal transition GO:0010718 ISO
    positive regulation of epithelial to mesenchymal transition GO:0010718 TAS
    positive regulation of heparan sulfate proteoglycan biosynthetic process GO:0010909 ISO
    positive regulation of heparan sulfate proteoglycan biosynthetic process GO:0010909 ISS
    Schwann cell proliferation GO:0014010 ISO
    morphogenesis of embryonic epithelium GO:0016331 IMP
    negative regulation of angiogenesis GO:0016525 IMP
    layer formation in cerebral cortex GO:0021819 IMP
    hypothalamus development GO:0021854 IMP
    central nervous system vasculogenesis GO:0022009 IMP
    hair cycle process GO:0022405 IMP
    hemopoiesis GO:0030097 IDA
    cell differentiation GO:0030154 IMP
    neuron differentiation GO:0030182 IMP
    T cell differentiation GO:0030217 IMP
    osteoclast differentiation GO:0030316 IMP
    osteoclast differentiation GO:0030316 IMP
    lung development GO:0030324 IMP
    male genitalia development GO:0030539 IMP
    regulation of epithelial cell differentiation GO:0030856 IMP
    positive regulation of epithelial cell differentiation GO:0030858 IMP
    forebrain development GO:0030900 IMP
    midbrain development GO:0030901 IMP
    hindbrain development GO:0030902 IMP
    regulation of centriole-centriole cohesion GO:0030997 ISO
    regulation of centriole-centriole cohesion GO:0030997 ISS
    pancreas development GO:0031016 IMP
    hair follicle morphogenesis GO:0031069 IMP
    regulation of protein ubiquitination GO:0031396 IEA
    regulation of protein ubiquitination GO:0031396 ISO
    regulation of myelination GO:0031641 IMP
    positive regulation of telomere maintenance via telomerase GO:0032212 IMP
    negative regulation of chondrocyte differentiation GO:0032331 IGI
    negative regulation of chondrocyte differentiation GO:0032331 IMP
    response to estradiol GO:0032355 ISO
    response to estradiol GO:0032355 ISS
    positive regulation of transcription elongation by RNA polymerase II GO:0032968 IMP
    T cell differentiation in thymus GO:0033077 IMP
    negative regulation of protein sumoylation GO:0033234 ISO
    negative regulation of protein sumoylation GO:0033234 ISS
    response to cytokine GO:0034097 ISO
    adherens junction organization GO:0034332 IMP
    adherens junction assembly GO:0034333 ISO
    adherens junction assembly GO:0034333 ISS
    protein localization to cell surface GO:0034394 ISO
    protein localization to cell surface GO:0034394 ISS
    embryonic heart tube development GO:0035050 IMP
    genitalia morphogenesis GO:0035112 IMP
    embryonic forelimb morphogenesis GO:0035115 IDA
    embryonic hindlimb morphogenesis GO:0035116 IMP
    embryonic skeletal limb joint morphogenesis GO:0036023 IGI
    astrocyte-dopaminergic neuron signaling GO:0036520 IMP
    regulation of cell population proliferation GO:0042127 IDA
    regulation of cell population proliferation GO:0042127 IMP
    regulation of T cell proliferation GO:0042129 IMP
    odontogenesis of dentin-containing tooth GO:0042475 IMP
    embryonic digit morphogenesis GO:0042733 IGI
    embryonic digit morphogenesis GO:0042733 IMP
    regulation of apoptotic process GO:0042981 IMP
    positive regulation of apoptotic process GO:0043065 ISO
    positive regulation of apoptotic process GO:0043065 ISS
    negative regulation of apoptotic process GO:0043066 ISO
    proteasome-mediated ubiquitin-dependent protein catabolic process GO:0043161 IEA
    proteasome-mediated ubiquitin-dependent protein catabolic process GO:0043161 ISO
    positive regulation of MAPK cascade GO:0043410 IGI
    negative regulation of neuron apoptotic process GO:0043524 IGI
    positive regulation of neuron apoptotic process GO:0043525 IEA
    positive regulation of neuron apoptotic process GO:0043525 ISO
    skin development GO:0043588 IMP
    response to estrogen GO:0043627 ISO
    positive regulation of molecular function GO:0044093 IDA
    canonical Wnt signaling pathway involved in mesenchymal stem cell differentiation GO:0044338 IMP
    bone resorption GO:0045453 IGI
    bone resorption GO:0045453 IMP
    regulation of cell differentiation GO:0045595 IDA
    negative regulation of cell differentiation GO:0045596 IMP
    positive regulation of cell differentiation GO:0045597 NAS
    positive regulation of endothelial cell differentiation GO:0045603 IMP
    regulation of osteoblast differentiation GO:0045667 IMP
    positive regulation of osteoblast differentiation GO:0045669 IMP
    regulation of osteoclast differentiation GO:0045670 IMP
    negative regulation of osteoclast differentiation GO:0045671 IMP
    positive regulation of fibroblast growth factor receptor signaling pathway GO:0045743 IMP
    negative regulation of DNA-templated transcription GO:0045892 IDA
    negative regulation of DNA-templated transcription GO:0045892 IMP
    negative regulation of DNA-templated transcription GO:0045892 ISO
    positive regulation of DNA-templated transcription GO:0045893 IDA
    positive regulation of DNA-templated transcription GO:0045893 IDA
    positive regulation of DNA-templated transcription GO:0045893 IMP
    positive regulation of DNA-templated transcription GO:0045893 IMP
    positive regulation of DNA-templated transcription GO:0045893 ISO
    positive regulation of transcription by RNA polymerase II GO:0045944 IBA
    positive regulation of transcription by RNA polymerase II GO:0045944 IDA
    positive regulation of transcription by RNA polymerase II GO:0045944 IDA
    positive regulation of transcription by RNA polymerase II GO:0045944 IGI
    positive regulation of transcription by RNA polymerase II GO:0045944 IGI
    positive regulation of transcription by RNA polymerase II GO:0045944 IMP
    positive regulation of transcription by RNA polymerase II GO:0045944 IMP
    positive regulation of transcription by RNA polymerase II GO:0045944 ISO
    positive regulation of transcription by RNA polymerase II GO:0045944 ISS
    negative regulation of mitotic cell cycle, embryonic GO:0045976 IMP
    cell maturation GO:0048469 IDA
    cell maturation GO:0048469 IMP
    synaptic vesicle transport GO:0048489 IMP
    animal organ development GO:0048513 IMP
    thymus development GO:0048538 IMP
    embryonic organ development GO:0048568 IMP
    oocyte development GO:0048599 IGI
    embryonic foregut morphogenesis GO:0048617 IMP
    positive regulation of skeletal muscle tissue development GO:0048643 IMP
    regulation of smooth muscle cell proliferation GO:0048660 ISO
    regulation of smooth muscle cell proliferation GO:0048660 ISS
    neuron fate determination GO:0048664 IMP
    oligodendrocyte differentiation GO:0048709 IMP
    negative regulation of oligodendrocyte differentiation GO:0048715 IMP
    regulation of neurogenesis GO:0050767 NAS
    negative regulation of neurogenesis GO:0050768 IMP
    synapse organization GO:0050808 IMP
    smooth muscle cell differentiation GO:0051145 IMP
    myoblast proliferation GO:0051450 IMP
    myoblast proliferation GO:0051450 IMP
    regulation of timing of anagen GO:0051884 IDA
    regulation of synapse assembly GO:0051963 IDA
    regulation of synapse assembly GO:0051963 IMP
    cardiac muscle cell proliferation GO:0060038 TAS
    oviduct development GO:0060066 IMP
    canonical Wnt signaling pathway GO:0060070 IBA
    canonical Wnt signaling pathway GO:0060070 IDA
    canonical Wnt signaling pathway GO:0060070 IDA
    canonical Wnt signaling pathway GO:0060070 IGI
    canonical Wnt signaling pathway GO:0060070 IMP
    canonical Wnt signaling pathway GO:0060070 IMP
    canonical Wnt signaling pathway GO:0060070 ISO
    limb development GO:0060173 IMP
    trachea morphogenesis GO:0060439 IMP
    trachea formation GO:0060440 IMP
    epithelial tube branching involved in lung morphogenesis GO:0060441 IMP
    epithelial tube branching involved in lung morphogenesis GO:0060441 IMP
    lung cell differentiation GO:0060479 IMP
    lung-associated mesenchyme development GO:0060484 IMP
    mesenchyme development GO:0060485 TAS
    lung epithelial cell differentiation GO:0060487 IMP
    lung induction GO:0060492 IMP
    epithelial cell differentiation involved in prostate gland development GO:0060742 IMP
    epithelial cell proliferation involved in prostate gland development GO:0060767 IMP
    positive regulation of epithelial cell proliferation involved in prostate gland development GO:0060769 IMP
    hair follicle placode formation GO:0060789 IGI
    hair follicle placode formation GO:0060789 IMP
    establishment of blood-brain barrier GO:0060856 IMP
    mesenchymal cell proliferation involved in lung development GO:0060916 IMP
    cardiac vascular smooth muscle cell differentiation GO:0060947 TAS
    coronary artery morphogenesis GO:0060982 TAS
    epicardium-derived cardiac vascular smooth muscle cell differentiation GO:0060983 TAS
    positive regulation of branching involved in lung morphogenesis GO:0061047 IMP
    endothelial tube morphogenesis GO:0061154 ISO
    endothelial tube morphogenesis GO:0061154 ISS
    fungiform papilla formation GO:0061198 IMP
    sympathetic ganglion development GO:0061549 IMP
    cranial ganglion development GO:0061550 IMP
    regulation of centromeric sister chromatid cohesion GO:0070602 IMP
    regulation of centromeric sister chromatid cohesion GO:0070602 ISO
    cellular response to mechanical stimulus GO:0071260 ISO
    cellular response to growth factor stimulus GO:0071363 ISO
    cellular response to growth factor stimulus GO:0071363 ISS
    cellular response to indole-3-methanol GO:0071681 ISO
    cellular response to indole-3-methanol GO:0071681 ISS
    renal vesicle formation GO:0072033 IMP
    renal inner medulla development GO:0072053 IMP
    renal outer medulla development GO:0072054 IMP
    nephron tubule formation GO:0072079 IMP
    stem cell proliferation GO:0072089 IMP
    mesenchyme morphogenesis GO:0072132 TAS
    regulation of nephron tubule epithelial cell differentiation GO:0072182 IMP
    mesenchymal stem cell differentiation GO:0072497 IMP
    mesenchymal stem cell differentiation GO:0072497 ISO
    negative regulation of canonical Wnt signaling pathway GO:0090090 IDA
    regulation of calcium ion import GO:0090279 ISO
    regulation of calcium ion import GO:0090279 ISS
    acinar cell differentiation GO:0090425 IMP
    synaptic vesicle clustering GO:0097091 IDA
    synaptic vesicle clustering GO:0097091 IMP
    apoptotic signaling pathway GO:0097190 IGI
    apoptotic signaling pathway GO:0097190 IMP
    cell-cell adhesion GO:0098609 IBA
    cell-cell adhesion GO:0098609 IMP
    cell-cell adhesion GO:0098609 ISO
    positive regulation of odontoblast differentiation GO:1901331 IMP
    negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway GO:1903377 IMP
    cranial skeletal system development GO:1904888 IMP
    midbrain dopaminergic neuron differentiation GO:1904948 IMP
    neuron projection extension GO:1990138 ISO
    neuron projection extension GO:1990138 ISS
    cellular response to insulin-like growth factor stimulus GO:1990314 ISO
    embryonic brain development GO:1990403 IMP
    dorsal root ganglion development GO:1990791 IMP
    establishment of blood-retinal barrier GO:1990963 IMP
    regulation of protein localization to cell surface GO:2000008 ISO
    regulation of protein localization to cell surface GO:2000008 ISS
    positive regulation of determination of dorsal identity GO:2000017 IDA
    positive regulation of neural precursor cell proliferation GO:2000179 IMP
    positive regulation of myoblast proliferation GO:2000288 IMP
    positive regulation of stem cell proliferation GO:2000648 IMP
    negative regulation of apoptotic signaling pathway GO:2001234 IGI
    negative regulation of apoptotic signaling pathway GO:2001234 IMP
Subcellular Localization
    euchromatin GO:0000791 IDA
    euchromatin GO:0000791 ISO
    spindle pole GO:0000922 IEA
    nucleus GO:0005634 IBA
    nucleus GO:0005634 IDA
    nucleus GO:0005634 IMP
    nucleus GO:0005634 IPI
    nucleus GO:0005634 ISO
    nucleoplasm GO:0005654 TAS
    transcription regulator complex GO:0005667 IDA
    transcription regulator complex GO:0005667 ISO
    cytoplasm GO:0005737 IBA
    cytoplasm GO:0005737 IDA
    cytoplasm GO:0005737 IPI
    cytoplasm GO:0005737 ISO
    centrosome GO:0005813 IDA
    centrosome GO:0005813 ISO
    cytosol GO:0005829 IDA
    cytosol GO:0005829 ISO
    cytosol GO:0005829 TAS
    plasma membrane GO:0005886 IDA
    plasma membrane GO:0005886 ISO
    plasma membrane GO:0005886 TAS
    cell-cell junction GO:0005911 IDA
    cell-cell junction GO:0005911 ISO
    adherens junction GO:0005912 IBA
    adherens junction GO:0005912 IDA
    adherens junction GO:0005912 ISO
    fascia adherens GO:0005916 IDA
    bicellular tight junction GO:0005923 IDA
    cell cortex GO:0005938 ISO
    cell cortex GO:0005938 ISS
    intercalated disc GO:0014704 IDA
    intercalated disc GO:0014704 ISO
    membrane GO:0016020 IDA
    membrane GO:0016020 ISO
    basolateral plasma membrane GO:0016323 IDA
    basolateral plasma membrane GO:0016323 ISO
    apical plasma membrane GO:0016324 ISO
    apicolateral plasma membrane GO:0016327 IDA
    lateral plasma membrane GO:0016328 IDA
    lateral plasma membrane GO:0016328 ISO
    catenin complex GO:0016342 IBA
    catenin complex GO:0016342 IDA
    catenin complex GO:0016342 IMP
    catenin complex GO:0016342 ISO
    catenin complex GO:0016342 ISS
    flotillin complex GO:0016600 IDA
    Z disc GO:0030018 IDA
    lamellipodium GO:0030027 IDA
    cell junction GO:0030054 ISO
    cell junction GO:0030054 ISS
    beta-catenin destruction complex GO:0030877 IDA
    beta-catenin destruction complex GO:0030877 ISO
    beta-catenin destruction complex GO:0030877 ISS
    cell projection membrane GO:0031253 IDA
    microvillus membrane GO:0031528 IDA
    nuclear membrane GO:0031965 ISO
    protein-containing complex GO:0032991 ISO
    protein-DNA complex GO:0032993 ISO
    protein-DNA complex GO:0032993 ISS
    Scrib-APC-beta-catenin complex GO:0034750 IDA
    presynaptic membrane GO:0042734 IDA
    dendritic shaft GO:0043198 ISO
    apical junction complex GO:0043296 IDA
    apical part of cell GO:0045177 IDA
    synapse GO:0045202 IDA
    postsynaptic membrane GO:0045211 IDA
    perinuclear region of cytoplasm GO:0048471 ISO
    perinuclear region of cytoplasm GO:0048471 ISS
    tight junction GO:0070160 ISO
    beta-catenin-TCF7L2 complex GO:0070369 ISO
    beta-catenin-TCF7L2 complex GO:0070369 ISS
    cell periphery GO:0071944 ISO
    cell periphery GO:0071944 ISS
    RNA polymerase II transcription regulator complex GO:0090575 IPI
    Schaffer collateral - CA1 synapse GO:0098685 IDA
    Schaffer collateral - CA1 synapse GO:0098685 IMP
    presynaptic active zone cytoplasmic component GO:0098831 IDA
    glutamatergic synapse GO:0098978 IDA
    glutamatergic synapse GO:0098978 IMP
    postsynaptic density, intracellular component GO:0099092 IDA
    beta-catenin-ICAT complex GO:1990711 IPI
    beta-catenin-TCF complex GO:1990907 IDA
    beta-catenin-TCF complex GO:1990907 ISO
    Wnt signalosome GO:1990909 IDA
 Experiment description of studies that identified Ctnnb1 in sEVs
1
Experiment ID 907
MISEV standards
✔
EM
Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
Enriched markers
✔
HSPA5
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample Colon cancer cells
Sample name C26
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 908
MISEV standards
✔
EM
Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
Enriched markers
✔
HSPA5
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample T-cell lymphoma cells
Sample name EL4
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for Ctnnb1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Usp9x 22284
Affinity Capture-Western Mus musculus
2 Tax1bp3  
Two-hybrid Mus musculus
Affinity Capture-Western Mus musculus
Reconstituted Complex Mus musculus
Two-hybrid Mus musculus
Phenotypic Suppression Mus musculus
3 TRAF4 9618
Two-hybrid Homo sapiens
4 Hnf1a  
Phenotypic Enhancement Mus musculus
5 Cdh1 12550
Affinity Capture-Western Mus musculus
Affinity Capture-Western Mus musculus
Affinity Capture-Western Mus musculus
Two-hybrid Mus musculus
Affinity Capture-Western Mus musculus
Affinity Capture-Western Mus musculus
Affinity Capture-Western Mus musculus
6 Pax3  
Phenotypic Suppression Mus musculus
Reconstituted Complex Mus musculus
7 Fmr1  
Affinity Capture-MS Mus musculus
8 Tcf7l2  
Affinity Capture-Western Mus musculus
Affinity Capture-Western Mus musculus
Phenotypic Suppression Mus musculus
Affinity Capture-Western Mus musculus
9 TCF7L2  
Reconstituted Complex Homo sapiens
10 Acp1 11431
Affinity Capture-Western Mus musculus
11 Pex5l  
Affinity Capture-MS Mus musculus
12 Ctnna1 12385
Affinity Capture-Western Mus musculus
13 Frmd5  
Co-fractionation Mus musculus
14 Unk  
Affinity Capture-RNA Mus musculus
15 Hmgb2 97165
Reconstituted Complex Mus musculus
16 MUC1 4582
Affinity Capture-Western Homo sapiens
17 Sox17  
Affinity Capture-Western Mus musculus
18 Gsk3b  
Biochemical Activity Mus musculus
Affinity Capture-Western Mus musculus
Two-hybrid Mus musculus
19 Fxr1 14359
Affinity Capture-MS Mus musculus
20 Tnik  
Affinity Capture-MS Mus musculus
21 BTRC 8945
Reconstituted Complex Homo sapiens
22 Pde4dip  
Affinity Capture-MS Mus musculus
23 Gja1 14609
Affinity Capture-Western Mus musculus
24 Ctnnb1 12387
Two-hybrid Mus musculus
Two-hybrid Mus musculus
25 GSK3B 2932
Biochemical Activity Homo sapiens
26 Ccnd1  
Phenotypic Suppression Mus musculus
27 Vcl 22330
Co-fractionation Mus musculus
28 Dlg4  
Affinity Capture-MS Mus musculus
29 Cul4a  
Affinity Capture-Western Mus musculus
30 Lrrk2  
Affinity Capture-Western Mus musculus
31 Axin2  
Affinity Capture-Western Mus musculus
Two-hybrid Mus musculus
Affinity Capture-Western Mus musculus
32 Slit2 20563
Co-localization Mus musculus
33 Ar  
Affinity Capture-Western Mus musculus
Affinity Capture-Western Mus musculus
34 Arhgap32  
Affinity Capture-Western Mus musculus
Two-hybrid Mus musculus
Reconstituted Complex Mus musculus
Affinity Capture-Western Mus musculus
35 Cops2 12848
Affinity Capture-Western Mus musculus
36 Nanog  
Affinity Capture-Western Mus musculus
37 Cdh2 12558
Affinity Capture-Western Mus musculus
Affinity Capture-Western Mus musculus
Affinity Capture-Western Mus musculus
Affinity Capture-Western Mus musculus
38 PIK3R1 5295
Affinity Capture-Western Homo sapiens
39 CTNNBIP1 56998
Co-crystal Structure Homo sapiens
40 Myc  
Co-localization Mus musculus
41 Ptprf  
Affinity Capture-Western Mus musculus
42 PSEN1 5663
Affinity Capture-Western Homo sapiens
43 Tcf4 21413
Phenotypic Suppression Mus musculus
Affinity Capture-Western Mus musculus
Two-hybrid Mus musculus
44 Tcf7l1  
Affinity Capture-Western Mus musculus
45 Wnt4  
Phenotypic Suppression Mus musculus
46 Axin1  
Synthetic Rescue Mus musculus
Affinity Capture-Western Mus musculus
Affinity Capture-Western Mus musculus
Affinity Capture-Western Mus musculus
Reconstituted Complex Mus musculus
47 Ctnnd1 12388
Affinity Capture-Western Mus musculus
Affinity Capture-Western Mus musculus
Co-fractionation Mus musculus
Affinity Capture-Western Mus musculus
48 Bmpr1a  
Phenotypic Enhancement Mus musculus
49 Pcp2  
Affinity Capture-Western Mus musculus
50 Psen1  
Affinity Capture-Western Mus musculus
Affinity Capture-Western Mus musculus
51 CDH15 1013
Affinity Capture-Western Homo sapiens
52 Nr5a1  
Affinity Capture-Western Mus musculus
53 Jun  
Affinity Capture-Western Mus musculus
54 Grin2b  
Affinity Capture-Western Mus musculus
55 Csnk1e  
Affinity Capture-Western Mus musculus
Biochemical Activity Mus musculus
Biochemical Activity Mus musculus
56 Dcx  
Affinity Capture-Western Mus musculus
57 Grin1  
Affinity Capture-Western Mus musculus
58 Nf2  
Affinity Capture-Western Mus musculus
59 Eed  
Affinity Capture-MS Mus musculus
60 Tia1  
Affinity Capture-MS Mus musculus
61 Fancd2  
Affinity Capture-MS Mus musculus
62 SNCA 6622
Affinity Capture-MS Homo sapiens
63 Cyfip2 76884
Affinity Capture-MS Mus musculus
64 Cby1  
Phenotypic Suppression Mus musculus
65 Pou5f1  
Affinity Capture-MS Mus musculus
Affinity Capture-Western Mus musculus
Affinity Capture-Western Mus musculus
66 Wnt9a  
Phenotypic Enhancement Mus musculus
67 Dlgap1  
Affinity Capture-MS Mus musculus
Affinity Capture-MS Mus musculus
68 Prop1  
Affinity Capture-Western Mus musculus
Reconstituted Complex Mus musculus
Phenotypic Enhancement Mus musculus
69 Syngap1  
Affinity Capture-MS Mus musculus
70 Kctd13  
Affinity Capture-MS Mus musculus
71 Pin1  
Affinity Capture-Western Mus musculus
72 Htt  
Affinity Capture-Western Mus musculus
73 CREBBP  
Biochemical Activity Homo sapiens
74 Ptprq  
Affinity Capture-Western Mus musculus
75 AXIN1  
Reconstituted Complex Homo sapiens
76 Sox2  
Phenotypic Suppression Mus musculus
Affinity Capture-Western Mus musculus
77 Rela  
Affinity Capture-Western Mus musculus
78 Crebbp  
Affinity Capture-Western Mus musculus
Two-hybrid Mus musculus
Affinity Capture-Western Mus musculus
Affinity Capture-Western Mus musculus
79 Ctnnbip1  
Affinity Capture-Western Mus musculus
Phenotypic Suppression Mus musculus
Two-hybrid Mus musculus
80 Casp3 12367
Biochemical Activity Mus musculus
81 Tsc1  
Affinity Capture-MS Mus musculus
82 Lnx1  
Affinity Capture-MS Mus musculus
83 Kifap3  
Affinity Capture-Western Mus musculus
Affinity Capture-Western Mus musculus
84 Neurl2  
Biochemical Activity Mus musculus
Affinity Capture-Western Mus musculus
Affinity Capture-Western Mus musculus
85 Smarca4  
Affinity Capture-Western Mus musculus
86 Esr1  
Affinity Capture-Western Mus musculus
Affinity Capture-Western Mus musculus
87 Lef1 16842
Affinity Capture-Western Mus musculus
Co-localization Mus musculus
Reconstituted Complex Mus musculus
Phenotypic Suppression Mus musculus
Affinity Capture-Western Mus musculus
88 EP300 2033
Biochemical Activity Homo sapiens
89 Apc  
Two-hybrid Mus musculus
Affinity Capture-Western Mus musculus
Reconstituted Complex Mus musculus
Co-crystal Structure Mus musculus
Affinity Capture-Western Mus musculus
Phenotypic Suppression Mus musculus
Two-hybrid Mus musculus
90 Kif3b  
Affinity Capture-Western Mus musculus
Affinity Capture-Western Mus musculus
View the network image/svg+xml
 Pathways in which Ctnnb1 is involved
PathwayEvidenceSource
Adherens junctions interactions IEA Reactome
Apoptosis IEA Reactome
Apoptotic cleavage of cell adhesion proteins IEA Reactome
Apoptotic cleavage of cellular proteins IEA Reactome
Apoptotic execution phase IEA Reactome
Beta-catenin independent WNT signaling IEA Reactome
Beta-catenin phosphorylation cascade IEA Reactome
Ca2+ pathway IEA Reactome
Cell junction organization IEA Reactome
Cell-Cell communication IEA Reactome
Cell-cell junction organization IEA Reactome
Cytosolic sensors of pathogen-associated DNA IEA Reactome
Deactivation of the beta-catenin transactivating complex IEA Reactome
Degradation of beta-catenin by the destruction complex IEA Reactome
Developmental Biology IEA Reactome
Disassembly of the destruction complex and recruitment of AXIN to the membrane IEA Reactome
Formation of the beta-catenin:TCF transactivating complex IEA Reactome
Gene expression (Transcription) IEA Reactome
Generic Transcription Pathway IEA Reactome
Immune System IEA Reactome
Innate Immune System IEA Reactome
LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production IEA Reactome
MITF-M-dependent gene expression IEA Reactome
MITF-M-regulated melanocyte development IEA Reactome
Myogenesis IEA Reactome
Programmed Cell Death IEA Reactome
Regulation of CDH11 Expression and Function IEA Reactome
Regulation of CDH11 function IEA Reactome
Regulation of Expression and Function of Type II Classical Cadherins IEA Reactome
Regulation of Homotypic Cell-Cell Adhesion IEA Reactome
Regulation of MITF-M-dependent genes involved in cell cycle and proliferation IEA Reactome
RHO GTPase Effectors IEA Reactome
RHO GTPases activate IQGAPs IEA Reactome
RNA Polymerase II Transcription IEA Reactome
RUNX3 regulates WNT signaling IEA Reactome
Signal Transduction IEA Reactome
Signaling by Receptor Tyrosine Kinases IEA Reactome
Signaling by Rho GTPases IEA Reactome
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 IEA Reactome
Signaling by VEGF IEA Reactome
Signaling by WNT IEA Reactome
TCF dependent signaling in response to WNT IEA Reactome
Transcriptional regulation by RUNX3 IEA Reactome
VEGFA-VEGFR2 Pathway IEA Reactome
VEGFR2 mediated vascular permeability IEA Reactome





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