Gene description for TRIM38
Gene name tripartite motif containing 38
Gene symbol TRIM38
Other names/aliases RNF15
RORET
Species Homo sapiens
 Database cross references - TRIM38
ExoCarta ExoCarta_10475
Vesiclepedia VP_10475
Entrez Gene 10475
HGNC 10059
UniProt O00635  
 TRIM38 identified in sEVs derived from the following tissue/cell type
Mesenchymal stem cells 36408942    
Thymus 23844026    
 Gene ontology annotations for TRIM38
Molecular Function
    transcription coactivator activity GO:0003713 IDA
    protein binding GO:0005515 IPI
    zinc ion binding GO:0008270 IEA
    ubiquitin protein ligase activity GO:0061630 IBA
    ubiquitin protein ligase activity GO:0061630 ISS
Biological Process
    regulation of gene expression GO:0010468 IBA
    protein sumoylation GO:0016925 IEA
    regulation of interferon-beta production GO:0032648 IEA
    positive regulation of canonical NF-kappaB signal transduction GO:0043123 HMP
    positive regulation of canonical NF-kappaB signal transduction GO:0043123 IBA
    positive regulation of canonical NF-kappaB signal transduction GO:0043123 IDA
    proteasome-mediated ubiquitin-dependent protein catabolic process GO:0043161 IEA
    positive regulation of viral genome replication GO:0045070 IEA
    innate immune response GO:0045087 IBA
    positive regulation of DNA-templated transcription GO:0045893 IEA
    regulation of viral entry into host cell GO:0046596 IBA
    positive regulation of viral entry into host cell GO:0046598 IDA
    negative regulation of defense response to virus GO:0050687 IEA
    positive regulation of DNA-binding transcription factor activity GO:0051091 IDA
    positive regulation of NF-kappaB transcription factor activity GO:0051092 IDA
    protein K48-linked ubiquitination GO:0070936 IEA
Subcellular Localization
    cytoplasm GO:0005737 IBA
    cytosol GO:0005829 TAS
 Experiment description of studies that identified TRIM38 in sEVs
1
Experiment ID 488
MISEV standards
✔
EM
Biophysical techniques
✔
CD9|CD81|CD63|GAPDH|SDCBP|LAMP1|TFRC|UCHL1|FLOT2|LAMP2|FLOT1|ICAM1|RAB5B|CD151|RAB35|TSG101|RAB5A|CD82
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 217
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|CD81|CD9|CD63
Enriched markers
✘ Negative markers
✔
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23844026    
Organism Homo sapiens
Experiment description Characterization of human thymic exosomes.
Authors "Skogberg G, Gudmundsdottir J, van der Post S, Sandstrom K, Bruhn S, Benson M, Mincheva-Nilsson L, Baranov V, Telemo E, Ekwall O."
Journal name PLoS One
Publication year 2013
Sample Thymus
Sample name Normal-Thymus
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for TRIM38
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 ATXN1 6310
Two-hybrid Homo sapiens
2 TRIM38 10475
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
3 SDCBP 6386
Two-hybrid Homo sapiens
4 TRAF6 7189
Affinity Capture-Western Homo sapiens
5 Smc1a  
Affinity Capture-MS Mus musculus
6 HSPA8 3312
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
7 EIF1B  
Two-hybrid Homo sapiens
8 STXBP1 6812
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
9 UBE2E3 10477
Two-hybrid Homo sapiens
10 HSPA1L 3305
Two-hybrid Homo sapiens
11 SLC2A1 6513
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
12 CUL3 8452
Affinity Capture-MS Homo sapiens
13 BYSL 705
Two-hybrid Homo sapiens
14 RFC5 5985
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
15 ELAVL1 1994
Affinity Capture-RNA Homo sapiens
16 UBE2D4  
Two-hybrid Homo sapiens
17 TAB3 257397
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
18 UBE2D2 7322
Two-hybrid Homo sapiens
19 TCEA2  
Two-hybrid Homo sapiens
20 IFNG 3458
Affinity Capture-MS Homo sapiens
21 Smc3 13006
Affinity Capture-MS Mus musculus
22 AZI2  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
23 UBE2I 7329
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
24 ZNF764 92595
Two-hybrid Homo sapiens
25 HSPA2 3306
Two-hybrid Homo sapiens
26 MTURN  
Two-hybrid Homo sapiens
27 UBE2E1  
Two-hybrid Homo sapiens
28 GORASP2 26003
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
29 TAB2  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Co-localization Homo sapiens
30 HSPA1A 3303
Two-hybrid Homo sapiens
31 FBXW7  
Affinity Capture-MS Homo sapiens
32 PIAS4  
Two-hybrid Homo sapiens
33 UBE2D3 7323
Two-hybrid Homo sapiens
34 GMCL1  
Two-hybrid Homo sapiens
35 TSPYL4 23270
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
36 UBE2U  
Two-hybrid Homo sapiens
37 TICAM1  
Affinity Capture-Western Homo sapiens
38 UBE2D1 7321
Two-hybrid Homo sapiens
39 UBE2E2  
Two-hybrid Homo sapiens
View the network image/svg+xml
 Pathways in which TRIM38 is involved
PathwayEvidenceSource
Cytokine Signaling in Immune system TAS Reactome
Immune System TAS Reactome
Interferon gamma signaling TAS Reactome
Interferon Signaling TAS Reactome





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