Gene description for IFNG
Gene name	interferon, gamma
Gene symbol	IFNG
Other names/aliases	IFG IFI
Species	Homo sapiens
Database cross references - IFNG
ExoCarta	ExoCarta_3458
Vesiclepedia	VP_3458
Entrez Gene	3458
HGNC	5438
MIM	147570
UniProt	P01579
IFNG identified in sEVs derived from the following tissue/cell type
Mesenchymal stem cells	Unpublished / Not applicable

Gene ontology annotations for IFNG

Molecular Function     cytokine activity GO:0005125 IBA     cytokine activity GO:0005125 IDA     cytokine activity GO:0005125 ISS     type II interferon receptor binding GO:0005133 IEA     protein binding GO:0005515 IPI Biological Process     negative regulation of transcription by RNA polymerase II GO:0000122 ISS     microglial cell activation GO:0001774 IGI     microglial cell activation GO:0001774 ISS     positive regulation of cytokine production GO:0001819 IDA     adaptive immune response GO:0002250 IBA     macrophage activation involved in immune response GO:0002281 IDA     apoptotic process GO:0006915 IGI     humoral immune response GO:0006959 IBA     cell surface receptor signaling pathway GO:0007166 TAS     cell surface receptor signaling pathway via JAK-STAT GO:0007259 ISS     positive regulation of cell population proliferation GO:0008284 ISS     response to virus GO:0009615 IDA     positive regulation of autophagy GO:0010508 IDA     positive regulation of gene expression GO:0010628 HDA     positive regulation of gene expression GO:0010628 IDA     positive regulation of gene expression GO:0010628 IDA     positive regulation of gene expression GO:0010628 IGI     positive regulation of gene expression GO:0010628 IMP     positive regulation of gene expression GO:0010628 ISS     negative regulation of gene expression GO:0010629 IDA     negative regulation of gene expression GO:0010629 ISS     positive regulation of epithelial cell migration GO:0010634 IDA     regulation of metabolic process GO:0019222 IGI     macrophage differentiation GO:0030225 IDA     negative regulation of epithelial cell differentiation GO:0030857 ISS     positive regulation of protein-containing complex assembly GO:0031334 IDA     negative regulation of interleukin-17 production GO:0032700 IDA     positive regulation of chemokine production GO:0032722 IDA     positive regulation of interleukin-1 beta production GO:0032731 ISS     positive regulation of interleukin-12 production GO:0032735 IDA     positive regulation of interleukin-23 production GO:0032747 IDA     positive regulation of interleukin-6 production GO:0032755 IDA     positive regulation of tumor necrosis factor production GO:0032760 ISS     positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation involved in immune response GO:0032834 IDA     positive regulation of peptidyl-serine phosphorylation of STAT protein GO:0033141 IDA     positive regulation of smooth muscle cell apoptotic process GO:0034393 IDA     Fc-gamma receptor signaling pathway involved in phagocytosis GO:0038096 IDA     type III interferon-mediated signaling pathway GO:0038196 IDA     positive regulation of protein import into nucleus GO:0042307 IDA     positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 IDA     positive regulation of MHC class II biosynthetic process GO:0045348 ISS     positive regulation of nitric oxide biosynthetic process GO:0045429 IDA     positive regulation of osteoclast differentiation GO:0045672 IDA     positive regulation of glycolytic process GO:0045821 ISS     negative regulation of DNA-templated transcription GO:0045892 IDA     positive regulation of transcription by RNA polymerase II GO:0045944 ISS     astrocyte activation GO:0048143 IDA     astrocyte activation GO:0048143 ISS     negative regulation of smooth muscle cell proliferation GO:0048662 IDA     positive regulation of inflammatory response GO:0050729 IDA     positive regulation of phagocytosis GO:0050766 ISS     positive regulation of neurogenesis GO:0050769 IGI     regulation of insulin secretion GO:0050796 IDA     positive regulation of membrane protein ectodomain proteolysis GO:0051044 IDA     defense response to virus GO:0051607 IEA     type II interferon-mediated signaling pathway GO:0060333 IDA     type II interferon-mediated signaling pathway GO:0060333 IGI     type II interferon-mediated signaling pathway GO:0060333 NAS     positive regulation of fructose 1,6-bisphosphate 1-phosphatase activity GO:0060550 IDA     positive regulation of fructose 1,6-bisphosphate metabolic process GO:0060552 IDA     positive regulation of vitamin D biosynthetic process GO:0060557 IDA     positive regulation of calcidiol 1-monooxygenase activity GO:0060559 IDA     positive regulation of protein serine/threonine kinase activity GO:0071902 IDA     positive regulation of protein deacetylation GO:0090312 IDA     extrinsic apoptotic signaling pathway GO:0097191 IDA     cell surface receptor signaling pathway via STAT GO:0097696 IDA     cellular response to virus GO:0098586 NAS     neuroinflammatory response GO:0150076 ISS     negative regulation of amyloid-beta clearance GO:1900222 ISS     positive regulation of cellular respiration GO:1901857 ISS     positive regulation of amyloid-beta formation GO:1902004 IGI     positive regulation of amyloid-beta formation GO:1902004 ISS     positive regulation of protein localization to plasma membrane GO:1903078 HDA     positive regulation of exosomal secretion GO:1903543 HDA     positive regulation of iron ion import across plasma membrane GO:1904440 ISS     positive regulation of NMDA glutamate receptor activity GO:1904783 ISS     positive regulation of core promoter binding GO:1904798 IDA     positive regulation of tumor necrosis factor (ligand) superfamily member 11 production GO:2000309 IDA Subcellular Localization     extracellular region GO:0005576 IDA     extracellular region GO:0005576 TAS     extracellular space GO:0005615 IBA     extracellular space GO:0005615 IDA