Gene description for STARD3
Gene name StAR-related lipid transfer (START) domain containing 3
Gene symbol STARD3
Other names/aliases CAB1
MLN64
es64
Species Homo sapiens
 Database cross references - STARD3
ExoCarta ExoCarta_10948
Vesiclepedia VP_10948
Entrez Gene 10948
HGNC 17579
MIM 607048
UniProt Q14849  
 STARD3 identified in sEVs derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
 Gene ontology annotations for STARD3
Molecular Function
    protein binding GO:0005515 IPI
    cholesterol binding GO:0015485 IBA
    cholesterol binding GO:0015485 IDA
    protein homodimerization activity GO:0042803 IDA
    cholesterol transfer activity GO:0120020 IEA
Biological Process
    lipid metabolic process GO:0006629 TAS
    progesterone biosynthetic process GO:0006701 IEA
    mitochondrial transport GO:0006839 TAS
    steroid metabolic process GO:0008202 TAS
    cholesterol metabolic process GO:0008203 TAS
    cholesterol transport GO:0030301 IBA
    cholesterol transport GO:0030301 IDA
    vesicle tethering to endoplasmic reticulum GO:0099044 IBA
    vesicle tethering to endoplasmic reticulum GO:0099044 IDA
Subcellular Localization
    nucleoplasm GO:0005654 IDA
    cytoplasm GO:0005737 TAS
    mitochondrion GO:0005739 IEA
    lysosomal membrane GO:0005765 HDA
    endosome GO:0005768 IDA
    endoplasmic reticulum membrane GO:0005789 IBA
    endoplasmic reticulum membrane GO:0005789 IDA
    cytosol GO:0005829 TAS
    late endosome membrane GO:0031902 IBA
    late endosome membrane GO:0031902 IDA
    intracellular membrane-bounded organelle GO:0043231 IDA
    organelle membrane contact site GO:0044232 IDA
    endoplasmic reticulum-endosome membrane contact site GO:0140284 IBA
    endoplasmic reticulum-endosome membrane contact site GO:0140284 IDA
 Experiment description of studies that identified STARD3 in sEVs
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for STARD3
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 RNF149 284996
Affinity Capture-MS Homo sapiens
2 BRINP2  
Affinity Capture-MS Homo sapiens
3 GPRC5B 51704
Affinity Capture-MS Homo sapiens
4 SGCA  
Affinity Capture-MS Homo sapiens
5 KCNMB3  
Affinity Capture-MS Homo sapiens
6 SLC15A1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
7 HLA-B 3106
Affinity Capture-MS Homo sapiens
8 VAPB 9217
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
9 TMPRSS5  
Affinity Capture-MS Homo sapiens
10 RAB7A 7879
Proximity Label-MS Homo sapiens
11 LAMTOR1 55004
Proximity Label-MS Homo sapiens
12 LAMP3  
Proximity Label-MS Homo sapiens
13 TSPYL6  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
14 RNF170 81790
Two-hybrid Homo sapiens
15 MFSD4  
Affinity Capture-MS Homo sapiens
16 LRRC25  
Affinity Capture-MS Homo sapiens
17 MME 4311
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
18 LAMP1 3916
Affinity Capture-MS Homo sapiens
19 CLEC2D  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
20 MANSC1 54682
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
21 IGHM 3507
Affinity Capture-MS Homo sapiens
22 ERGIC3 51614
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
23 BSCL2  
Affinity Capture-MS Homo sapiens
24 GPR12  
Affinity Capture-MS Homo sapiens
25 TMPRSS11B 132724
Affinity Capture-MS Homo sapiens
26 TMEM9B 56674
Affinity Capture-MS Homo sapiens
27 LAMP2 3920
Proximity Label-MS Homo sapiens
28 KLRB1  
Affinity Capture-MS Homo sapiens
29 STK36  
Affinity Capture-MS Homo sapiens
30 OPRL1 4987
Affinity Capture-MS Homo sapiens
31 FFAR1  
Affinity Capture-MS Homo sapiens
32 SPACA1 81833
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
33 HEPACAM2  
Affinity Capture-MS Homo sapiens
34 CTXN1  
Affinity Capture-MS Homo sapiens
35 KCNMB2  
Affinity Capture-MS Homo sapiens
36 CHRM3 1131
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
37 KCNE3  
Affinity Capture-MS Homo sapiens
38 VSIG4  
Affinity Capture-MS Homo sapiens
39 CST11  
Affinity Capture-MS Homo sapiens
40 PCDHGC4  
Affinity Capture-MS Homo sapiens
41 C19orf26 255057
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
42 SLC22A2 6582
Affinity Capture-MS Homo sapiens
43 RAB9A 9367
Proximity Label-MS Homo sapiens
44 CACNG4  
Affinity Capture-MS Homo sapiens
45 TMEM231 79583
Affinity Capture-MS Homo sapiens
46 CREB3  
Two-hybrid Homo sapiens
47 VIPR1  
Affinity Capture-MS Homo sapiens
48 P2RX2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
49 NIPAL1  
Affinity Capture-MS Homo sapiens
50 KLRC1  
Affinity Capture-MS Homo sapiens
51 HLA-DRB3 3125
Affinity Capture-MS Homo sapiens
52 HLA-DRB1 3123
Affinity Capture-MS Homo sapiens
53 SLC1A1 6505
Affinity Capture-MS Homo sapiens
54 SDF4 51150
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
55 PMEL 6490
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
56 CLEC4E  
Affinity Capture-MS Homo sapiens
57 AVPR2  
Affinity Capture-MS Homo sapiens
58 GPR173  
Affinity Capture-MS Homo sapiens
59 RNF13 11342
Affinity Capture-MS Homo sapiens
60 TTYH1  
Affinity Capture-MS Homo sapiens
61 TAS1R2  
Affinity Capture-MS Homo sapiens
62 GOPC 57120
Two-hybrid Homo sapiens
63 HLA-C 3107
Affinity Capture-MS Homo sapiens
64 EDAR  
Affinity Capture-MS Homo sapiens
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