Gene description for PMEL
Gene name	premelanosome protein
Gene symbol	PMEL
Other names/aliases	D12S53E ME20 ME20-M ME20M P1 P100 PMEL17 SI SIL SILV gp100
Species	Homo sapiens
Database cross references - PMEL
ExoCarta	ExoCarta_6490
Vesiclepedia	VP_6490
Entrez Gene	6490
HGNC	10880
MIM	155550
UniProt	P40967
PMEL identified in sEVs derived from the following tissue/cell type
Malignant pleural effusions	12147373
Melanoma cells	25950383
Melanoma cells	25950383
Melanoma cells	25950383
Melanoma cells	25950383

Gene ontology annotations for PMEL

Molecular Function     protein binding GO:0005515 IPI     identical protein binding GO:0042802 IPI Biological Process     melanosome organization GO:0032438 IBA     melanosome organization GO:0032438 IDA     melanin biosynthetic process GO:0042438 IEA     positive regulation of melanin biosynthetic process GO:0048023 IEA Subcellular Localization     endoplasmic reticulum GO:0005783 IDA     endoplasmic reticulum membrane GO:0005789 IDA     Golgi apparatus GO:0005794 IDA     plasma membrane GO:0005886 IBA     multivesicular body membrane GO:0032585 IDA     cis-Golgi network membrane GO:0033106 IDA     melanosome membrane GO:0033162 IDA     melanosome membrane GO:0033162 TAS     melanosome GO:0042470 IBA     melanosome GO:0042470 IDA     extracellular exosome GO:0070062 IDA     multivesicular body, internal vesicle GO:0097487 IDA