Gene description for RNF13
Gene name ring finger protein 13
Gene symbol RNF13
Other names/aliases RZF
Species Homo sapiens
 Database cross references - RNF13
ExoCarta ExoCarta_11342
Vesiclepedia VP_11342
Entrez Gene 11342
HGNC 10057
MIM 609247
UniProt O43567  
 RNF13 identified in sEVs derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
 Gene ontology annotations for RNF13
Molecular Function
    ubiquitin-protein transferase activity GO:0004842 ISS
    protein binding GO:0005515 IPI
    JUN kinase binding GO:0008432 IDA
    metal ion binding GO:0046872 IEA
    ubiquitin protein ligase activity GO:0061630 IBA
Biological Process
    ubiquitin-dependent protein catabolic process GO:0006511 IBA
    positive regulation of JNK cascade GO:0046330 IMP
    organelle localization GO:0051640 IMP
    protein autoubiquitination GO:0051865 ISS
Subcellular Localization
    nuclear inner membrane GO:0005637 IEA
    nucleoplasm GO:0005654 IDA
    cytoplasm GO:0005737 IBA
    lysosomal membrane GO:0005765 HDA
    lysosomal membrane GO:0005765 IBA
    lysosomal membrane GO:0005765 ISS
    endosome GO:0005768 IDA
    endoplasmic reticulum GO:0005783 IDA
    endoplasmic reticulum membrane GO:0005789 IEA
    cytosol GO:0005829 IDA
    late endosome membrane GO:0031902 ISS
    intracellular membrane-bounded organelle GO:0043231 IDA
 Experiment description of studies that identified RNF13 in sEVs
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for RNF13
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 AP3S1 1176
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
2 IVD 3712
Affinity Capture-MS Homo sapiens
3 HPSE2  
Affinity Capture-MS Homo sapiens
4 AP3S2 10239
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
5 PGK2 5232
Affinity Capture-MS Homo sapiens
6 LGALS9 3965
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
7 UBE2N 7334
Two-hybrid Homo sapiens
8 KLRC3  
Affinity Capture-MS Homo sapiens
9 MYCN  
Affinity Capture-MS Homo sapiens
10 ERN1  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
11 VTI1B 10490
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
12 NES 10763
Affinity Capture-MS Homo sapiens
13 STX12 23673
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
14 RNF167 26001
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
15 PGRMC1 10857
Co-localization Homo sapiens
16 STAT5A 6776
Affinity Capture-MS Homo sapiens
17 DHRS7 51635
Affinity Capture-MS Homo sapiens
18 AP1S2 8905
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
19 SQSTM1 8878
Affinity Capture-Western Homo sapiens
20 DCX  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
21 UBE2E3 10477
Two-hybrid Homo sapiens
22 MANSC1 54682
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
23 LGALS1 3956
Affinity Capture-MS Homo sapiens
24 HDGFRP3 50810
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
25 LAMP2 3920
Co-localization Homo sapiens
26 UBE2E1  
Two-hybrid Homo sapiens
27 SNAPIN 23557
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
28 PI4K2A 55361
Affinity Capture-MS Homo sapiens
29 TMEM55B 90809
Affinity Capture-MS Homo sapiens
30 TSPAN3 10099
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
31 STARD3 10948
Affinity Capture-MS Homo sapiens
32 TMED5 50999
Affinity Capture-MS Homo sapiens
33 NXF1 10482
Affinity Capture-RNA Homo sapiens
34 VAMP7 6845
Affinity Capture-MS Homo sapiens
35 CLCN7 1186
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
36 UBE2D2 7322
Two-hybrid Homo sapiens
37 UBE2D4  
Two-hybrid Homo sapiens
38 MYC  
Affinity Capture-MS Homo sapiens
39 SEC11A 23478
Affinity Capture-MS Homo sapiens
40 TYK2 7297
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
41 LMNB1 4001
Co-purification Homo sapiens
42 AP1G2 8906
Affinity Capture-MS Homo sapiens
43 CHEK1  
Affinity Capture-MS Homo sapiens
44 HSDL1 83693
Affinity Capture-MS Homo sapiens
45 NR2F2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
46 CLEC11A 6320
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
47 VIPR1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
48 RNF13 11342
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
49 UBE2D3 7323
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
50 NR2F1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
51 LGALS8 3964
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
52 CD63 967
Co-localization Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
53 AP3D1 8943
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
54 SPINT2 10653
Affinity Capture-MS Homo sapiens
55 CCNY 219771
Affinity Capture-MS Homo sapiens
56 SPCS2 9789
Affinity Capture-MS Homo sapiens
57 UBE2D1 7321
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
View the network image/svg+xml
 Pathways in which RNF13 is involved
No pathways found





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