Gene description for IVD
Gene name isovaleryl-CoA dehydrogenase
Gene symbol IVD
Other names/aliases ACAD2
Species Homo sapiens
 Database cross references - IVD
ExoCarta ExoCarta_3712
Vesiclepedia VP_3712
Entrez Gene 3712
HGNC 6186
MIM 607036
UniProt P26440  
 IVD identified in sEVs derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
 Gene ontology annotations for IVD
Molecular Function
    protein binding GO:0005515 IPI
    3-methylbutanoyl-CoA dehydrogenase activity GO:0008470 IBA
    3-methylbutanoyl-CoA dehydrogenase activity GO:0008470 IDA
    3-methylbutanoyl-CoA dehydrogenase activity GO:0008470 ISS
    identical protein binding GO:0042802 ISS
    flavin adenine dinucleotide binding GO:0050660 IEA
Biological Process
    L-leucine catabolic process GO:0006552 IBA
    L-leucine catabolic process GO:0006552 IDA
    L-leucine catabolic process GO:0006552 IEA
    L-leucine catabolic process GO:0006552 ISS
    branched-chain amino acid catabolic process GO:0009083 IDA
    fatty acid beta-oxidation using acyl-CoA dehydrogenase GO:0033539 IDA
Subcellular Localization
    nucleoplasm GO:0005654 IDA
    mitochondrion GO:0005739 HTP
    mitochondrion GO:0005739 IBA
    mitochondrion GO:0005739 IDA
    mitochondrial matrix GO:0005759 ISS
    mitochondrial matrix GO:0005759 TAS
 Experiment description of studies that identified IVD in sEVs
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for IVD
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 IVD 3712
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
2 NIPSNAP3A  
Affinity Capture-MS Homo sapiens
3 LYRM2  
Affinity Capture-MS Homo sapiens
4 PLEKHA4 57664
Affinity Capture-MS Homo sapiens
5 PMPCB 9512
Affinity Capture-MS Homo sapiens
6 TERF2  
Affinity Capture-MS Homo sapiens
7 PSEN1 5663
Co-fractionation Homo sapiens
8 MRRF  
Proximity Label-MS Homo sapiens
9 ALDH9A1 223
Co-fractionation Homo sapiens
10 MAPK15  
Co-fractionation Homo sapiens
11 RMND1 55005
Proximity Label-MS Homo sapiens
12 MRPS30 10884
Affinity Capture-MS Homo sapiens
13 TXNRD2 10587
Co-fractionation Homo sapiens
14 HMOX2 3163
Co-fractionation Homo sapiens
15 AHNAK 79026
Cross-Linking-MS (XL-MS) Homo sapiens
16 NUDT13  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
17 TRUB2  
Proximity Label-MS Homo sapiens
18 MGAT5B  
Two-hybrid Homo sapiens
19 SLC25A10 1468
Affinity Capture-MS Homo sapiens
20 MTG2  
Proximity Label-MS Homo sapiens
21 FASTKD5  
Proximity Label-MS Homo sapiens
22 ECHDC2 55268
Affinity Capture-MS Homo sapiens
23 FAHD1 81889
Affinity Capture-MS Homo sapiens
24 PARK2  
Affinity Capture-MS Homo sapiens
25 TRIM43  
Affinity Capture-MS Homo sapiens
26 EPRS 2058
Cross-Linking-MS (XL-MS) Homo sapiens
Cross-Linking-MS (XL-MS) Homo sapiens
27 DDX58 23586
Affinity Capture-RNA Homo sapiens
28 SLC25A41  
Affinity Capture-MS Homo sapiens
29 KIR3DL2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
30 LRRC49  
Affinity Capture-MS Homo sapiens
31 ACTN3 89
Two-hybrid Homo sapiens
32 PLIN1  
Cross-Linking-MS (XL-MS) Homo sapiens
33 PMPCA 23203
Proximity Label-MS Homo sapiens
Affinity Capture-MS Homo sapiens
34 ACADM 34
Co-fractionation Homo sapiens
35 GPSM3  
Two-hybrid Homo sapiens
36 STK11 6794
Affinity Capture-MS Homo sapiens
37 ACAD9 28976
Proximity Label-MS Homo sapiens
38 YARS2  
Affinity Capture-MS Homo sapiens
39 HINT2 84681
Proximity Label-MS Homo sapiens
40 HMGCL 3155
Affinity Capture-MS Homo sapiens
41 QRSL1  
Affinity Capture-MS Homo sapiens
42 RNF13 11342
Affinity Capture-MS Homo sapiens
43 CCDC53 51019
Affinity Capture-MS Homo sapiens
44 TMEM184A  
Affinity Capture-MS Homo sapiens
45 ETFA 2108
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
46 METTL17  
Proximity Label-MS Homo sapiens
47 ZBED4 9889
Cross-Linking-MS (XL-MS) Homo sapiens
48 HIST1H1D 3007
Affinity Capture-MS Homo sapiens
49 CS 1431
Proximity Label-MS Homo sapiens
50 ETFB 2109
Affinity Capture-Western Homo sapiens
51 MCUR1 63933
Proximity Label-MS Homo sapiens
52 PGD 5226
Co-fractionation Homo sapiens
53 ECHS1 1892
Co-fractionation Homo sapiens
54 ACAA2 10449
Co-fractionation Homo sapiens
View the network image/svg+xml



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