Gene description for Rhob
Gene name ras homolog gene family, member B
Gene symbol Rhob
Other names/aliases AA017882
Arh6
Arhb
Species Mus musculus
 Database cross references - Rhob
ExoCarta ExoCarta_11852
Vesiclepedia VP_11852
Entrez Gene 11852
UniProt P62746  
 Rhob identified in sEVs derived from the following tissue/cell type
Mov neuroglial cells 15210972    
 Gene ontology annotations for Rhob
Molecular Function
    GTPase activity GO:0003924 IBA
    GTPase activity GO:0003924 IEA
    protein binding GO:0005515 IPI
    GTP binding GO:0005525 IBA
    GTP binding GO:0005525 TAS
    GDP binding GO:0019003 IDA
Biological Process
    mitotic cytokinesis GO:0000281 ISO
    mitotic cytokinesis GO:0000281 ISS
    angiogenesis GO:0001525 IEA
    intracellular protein transport GO:0006886 IMP
    apoptotic process GO:0006915 IEA
    actin filament organization GO:0007015 IBA
    cell adhesion GO:0007155 IDA
    signal transduction GO:0007165 IBA
    small GTPase-mediated signal transduction GO:0007264 IEA
    endosome to lysosome transport GO:0008333 ISO
    endosome to lysosome transport GO:0008333 ISS
    positive regulation of endothelial cell migration GO:0010595 IEA
    positive regulation of endothelial cell migration GO:0010595 ISO
    cell differentiation GO:0030154 IEA
    regulation of cell migration GO:0030334 ISO
    negative regulation of cell migration GO:0030336 IEA
    negative regulation of cell migration GO:0030336 ISO
    positive regulation of apoptotic process GO:0043065 IDA
    positive regulation of apoptotic process GO:0043065 ISO
    positive regulation of apoptotic process GO:0043065 ISS
    positive regulation of angiogenesis GO:0045766 IMP
    negative regulation of cell cycle GO:0045786 IMP
    endothelial tube morphogenesis GO:0061154 IEA
    endothelial tube morphogenesis GO:0061154 ISO
    cellular response to hydrogen peroxide GO:0070301 ISO
    cellular response to hydrogen peroxide GO:0070301 ISS
    cellular response to ionizing radiation GO:0071479 ISO
    cellular response to ionizing radiation GO:0071479 ISS
    regulation of modification of postsynaptic structure GO:0099159 IDA
    regulation of modification of postsynaptic structure GO:0099159 IMP
Subcellular Localization
    nucleus GO:0005634 IDA
    early endosome GO:0005769 IDA
    late endosome GO:0005770 IDA
    cytosol GO:0005829 ISO
    plasma membrane GO:0005886 IBA
    plasma membrane GO:0005886 IDA
    plasma membrane GO:0005886 ISO
    plasma membrane GO:0005886 ISS
    plasma membrane GO:0005886 TAS
    endosome membrane GO:0010008 ISO
    endosome membrane GO:0010008 ISS
    membrane GO:0016020 IDA
    membrane GO:0016020 ISO
    late endosome membrane GO:0031902 IEA
    cleavage furrow GO:0032154 ISO
    cleavage furrow GO:0032154 ISS
    synapse GO:0045202 ISO
    Schaffer collateral - CA1 synapse GO:0098685 IDA
    Schaffer collateral - CA1 synapse GO:0098685 IMP
 Experiment description of studies that identified Rhob in sEVs
1
Experiment ID 39
MISEV standards
IEM
Biophysical techniques
TSG101|HSC70|FLOT1
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 15210972    
Organism Mus musculus
Experiment description Cells release prions in association with exosomes.
Authors "Fevrier B, Vilette D, Archer F, Loew D, Faigle W, Vidal M, Laude H, Raposo G"
Journal name PNAS
Publication year 2004
Sample Mov neuroglial cells
Sample name Mov neuroglial cell
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density 1.14 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [QSTAR]
Western blotting
Immunoelectron Microscopy
 Protein-protein interactions for Rhob
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Pde6d  
Co-fractionation Mus musculus
2 Rac1 19353
Co-fractionation Mus musculus
3 Cit 12704
Co-fractionation Mus musculus
4 Map1a  
Affinity Capture-Western Mus musculus
5 Sstr3  
Proximity Label-MS Mus musculus
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