Gene description for Hba-a1
Gene name hemoglobin alpha, adult chain 1
Gene symbol Hba-a1
Other names/aliases Hba
Hba1
Hbat1
Species Mus musculus
 Database cross references - Hba-a1
ExoCarta ExoCarta_15122
Vesiclepedia VP_15122
Entrez Gene 15122
 Hba-a1 identified in sEVs derived from the following tissue/cell type
Mast cells 17486113    
 Gene ontology annotations for Hba-a1
Molecular Function
    amyloid-beta binding GO:0001540 ISO
    G protein-coupled receptor binding GO:0001664 ISO
    peroxidase activity GO:0004601 IBA
    peroxidase activity GO:0004601 ISO
    oxygen carrier activity GO:0005344 IBA
    oxygen carrier activity GO:0005344 IEA
    iron ion binding GO:0005506 IEA
    oxygen binding GO:0019825 IBA
    oxygen binding GO:0019825 IEA
    oxygen binding GO:0019825 ISO
    heme binding GO:0020037 IBA
    heme binding GO:0020037 IEA
    heme binding GO:0020037 ISO
    haptoglobin binding GO:0031720 IBA
    haptoglobin binding GO:0031720 ISO
    organic acid binding GO:0043177 ISO
    protein-containing complex binding GO:0044877 ISO
Biological Process
    in utero embryonic development GO:0001701 IGI
    response to bacterium GO:0009617 IEP
    carbon dioxide transport GO:0015670 NAS
    oxygen transport GO:0015671 ISO
    nitric oxide transport GO:0030185 ISO
    response to stilbenoid GO:0035634 IEP
    hydrogen peroxide catabolic process GO:0042744 IBA
    erythrocyte development GO:0048821 IGI
Subcellular Localization
    extracellular space GO:0005615 ISO
    hemoglobin complex GO:0005833 IBA
    hemoglobin complex GO:0005833 IPI
    hemoglobin complex GO:0005833 ISO
    hemoglobin complex GO:0005833 ISS
    haptoglobin-hemoglobin complex GO:0031838 IBA
    haptoglobin-hemoglobin complex GO:0031838 ISO
    myelin sheath GO:0043209 HDA
 Experiment description of studies that identified Hba-a1 in sEVs
1
Experiment ID 15
MISEV standards
EM
Biophysical techniques
CD63
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 17486113    
Organism Mus musculus
Homo sapiens
Experiment description Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells.
Authors "Valadi H, Ekstrom K, Bossios A, Sjostrand M, Lee JJ, Lotvall JO"
Journal name NCB
Publication year 2007
Sample Mast cells
Sample name MC9
Bone marrow-derived mast cells
HMC-1
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.11-1.21 g/mL
Molecules identified in the study Protein
mRNA
miRNA
Methods used in the study Mass spectrometry [MALDI TOF]
Western blotting
Microarray
miRCURY LNA Array
 Protein-protein interactions for Hba-a1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Invs  
Affinity Capture-MS Mus musculus
2 Ctsd 13033
Biochemical Activity Mus musculus
3 Kctd13  
Affinity Capture-MS Mus musculus
4 GUCD1  
Two-hybrid Homo sapiens
5 Ctsb 13030
Biochemical Activity Mus musculus
6 Ctsl 13039
Biochemical Activity Mus musculus
View the network image/svg+xml
 Pathways in which Hba-a1 is involved
No pathways found





Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here