Gene description for Hnrnpl
Gene name heterogeneous nuclear ribonucleoprotein L
Gene symbol Hnrnpl
Other names/aliases C79783
D830027H13Rik
Hnrpl
Species Mus musculus
 Database cross references - Hnrnpl
ExoCarta ExoCarta_15388
Vesiclepedia VP_15388
Entrez Gene 15388
UniProt Q8R081  
 Hnrnpl identified in sEVs derived from the following tissue/cell type
Colon cancer cells 37309723    
T-cell lymphoma cells 37309723    
 Gene ontology annotations for Hnrnpl
Molecular Function
    transcription cis-regulatory region binding GO:0000976 ISO
    transcription cis-regulatory region binding GO:0000976 ISS
    RNA binding GO:0003723 IDA
    mRNA binding GO:0003729 IBA
    mRNA 3'-UTR binding GO:0003730 ISO
    protein binding GO:0005515 IPI
    pre-mRNA intronic binding GO:0097157 ISO
    pre-mRNA intronic binding GO:0097157 ISS
    mRNA CDS binding GO:1990715 ISO
Biological Process
    regulation of alternative mRNA splicing, via spliceosome GO:0000381 IMP
    regulation of alternative mRNA splicing, via spliceosome GO:0000381 ISO
    regulation of alternative mRNA splicing, via spliceosome GO:0000381 ISS
    mRNA processing GO:0006397 IEA
    regulation of RNA splicing GO:0043484 IBA
    negative regulation of DNA-templated transcription GO:0045892 ISO
    negative regulation of DNA-templated transcription GO:0045892 ISS
Subcellular Localization
    chromatin GO:0000785 ISO
    chromatin GO:0000785 ISS
    nucleus GO:0005634 IBA
    nucleus GO:0005634 ISO
    nucleoplasm GO:0005654 ISO
    nucleoplasm GO:0005654 ISS
    cytoplasm GO:0005737 ISO
    cytoplasm GO:0005737 ISS
    ribonucleoprotein granule GO:0035770 ISO
    ribonucleoprotein granule GO:0035770 ISS
    pronucleus GO:0045120 IDA
    synapse GO:0045202 EXP
    synapse GO:0045202 IDA
    perinuclear region of cytoplasm GO:0048471 ISO
    ribonucleoprotein complex GO:1990904 ISO
    ribonucleoprotein complex GO:1990904 ISS
 Experiment description of studies that identified Hnrnpl in sEVs
1
Experiment ID 907
MISEV standards
✔
EM
Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
Enriched markers
✔
HSPA5
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample Colon cancer cells
Sample name C26
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 908
MISEV standards
✔
EM
Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
Enriched markers
✔
HSPA5
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample T-cell lymphoma cells
Sample name EL4
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for Hnrnpl
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Ogg1  
Affinity Capture-MS Mus musculus
2 Eprs 107508
Co-fractionation Mus musculus
3 Rplp0 11837
Co-fractionation Mus musculus
4 Hnrnpu 51810
Co-fractionation Mus musculus
5 Fmr1  
Co-fractionation Mus musculus
6 Atxn1  
Affinity Capture-MS Mus musculus
7 Foxp3  
Affinity Capture-MS Mus musculus
8 Eed  
Affinity Capture-MS Mus musculus
9 MKRN1 23608
Affinity Capture-MS Homo sapiens
10 Atxn2 20239
Co-fractionation Mus musculus
11 Tfe3  
Affinity Capture-MS Mus musculus
12 Mapt  
Affinity Capture-MS Mus musculus
13 Fzr1  
Affinity Capture-MS Mus musculus
14 Pou5f1  
Affinity Capture-MS Mus musculus
Affinity Capture-MS Mus musculus
15 Unk  
Affinity Capture-RNA Mus musculus
16 Mettl21e  
Affinity Capture-MS Mus musculus
17 Fancd2  
Affinity Capture-MS Mus musculus
18 Ilf2 67781
Co-fractionation Mus musculus
19 Pabpc1 18458
Co-fractionation Mus musculus
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