Gene description for Ifngr1
Gene name interferon gamma receptor 1
Gene symbol Ifngr1
Other names/aliases CD119
IFN-gammaR
Ifgr
Ifngr
Nktar
Species Mus musculus
 Database cross references - Ifngr1
ExoCarta ExoCarta_15979
Vesiclepedia VP_15979
Entrez Gene 15979
UniProt P15261  
 Ifngr1 identified in sEVs derived from the following tissue/cell type
Colon cancer cells 37309723    
T-cell lymphoma cells 37309723    
 Gene ontology annotations for Ifngr1
Molecular Function
    cytokine receptor activity GO:0004896 IBA
    type II interferon receptor activity GO:0004906 IEA
    type II interferon receptor activity GO:0004906 ISO
    cytokine binding GO:0019955 IEA
Biological Process
    microglial cell activation GO:0001774 IGI
    positive regulation of gene expression GO:0010628 IGI
    cytokine-mediated signaling pathway GO:0019221 IBA
    positive regulation of tumor necrosis factor production GO:0032760 IGI
    type III interferon-mediated signaling pathway GO:0038196 IEA
    type III interferon-mediated signaling pathway GO:0038196 ISO
    astrocyte activation GO:0048143 IGI
    defense response to virus GO:0051607 IMP
    type II interferon-mediated signaling pathway GO:0060333 IEA
    type II interferon-mediated signaling pathway GO:0060333 ISO
    negative regulation of amyloid-beta clearance GO:1900222 IGI
    positive regulation of amyloid-beta formation GO:1902004 IGI
Subcellular Localization
    plasma membrane GO:0005886 IBA
    plasma membrane GO:0005886 IEA
    plasma membrane GO:0005886 ISO
    plasma membrane GO:0005886 ISO
    membrane GO:0016020 ISO
    dendrite GO:0030425 ISO
    vesicle GO:0031982 ISO
 Experiment description of studies that identified Ifngr1 in sEVs
1
Experiment ID 907
MISEV standards
✔
EM
Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
Enriched markers
✔
HSPA5
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample Colon cancer cells
Sample name C26
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 908
MISEV standards
✔
EM
Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
Enriched markers
✔
HSPA5
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample T-cell lymphoma cells
Sample name EL4
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for Ifngr1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Stat1 20846
Affinity Capture-Western Mus musculus
2 Tmem173  
Proximity Label-MS Mus musculus
3 Jak2 16452
Co-fractionation Mus musculus
4 Canx 12330
Co-fractionation Mus musculus
5 Rnf19b  
Affinity Capture-Western Mus musculus
6 Socs1  
Affinity Capture-Western Mus musculus
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